Oxidative Stress Markers in Patients with Primary Open-Angle Glaucoma

Ghanem, Asaad A.; Arafa, Lamiaa F.; El‐Baz, Ayman

doi:10.3109/02713680903548970

Cited by 122 publications

(116 citation statements)

References 15 publications

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“…But, about serum superoxide dismutase, the present study reported that it increased significantly in group B of untreated POAG patients and also in group C of patients of POAG under treatment in comparison to the control group, in agreement with Erdurmuş et al (2011) [11], who reported the same results, in addition Ghanem et al (2010) [19], who found that superoxide dismutase increased significantly in aqueous humor in patient of POAG. But, Majsterek et al (2011) [14], reported that SOD was decreased in patients with POAG as it is considered anti-oxidant factor, the present study and the previous two studies that agreed in their results of increase of SOD in patients of POAG explained this increase to be a compensatory mechanism for anti-oxidant activity against [14], who stated that MDA increased in cases of POAG as an oxidative stress biomarker.…”

Section: Discussionsupporting

confidence: 81%

The Role of Serum Ceruloplasmin and Oxidative Stress Markers in Primary Open Angle Glaucoma

Sharkh¹,

Nada²,

Moety³

et al. 2018

OJOph

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Purpose: The study aimed at evaluation of the role of ceruloplasmin (A protein involved in iron homeostasis and can inactivate free radicals) and other oxidative stress markers as superoxide dismutase (SOD), malondialdehyde (MDA) and catalase activity (CAT) in primary open angle glaucoma (POAG). Methods: This observational case control study included 90 persons divided into 3 equal groups: group A of 30 normal persons as a control group, group B of 30 patients of untreated (POAG) (firstly diagnosed) by the clinical characters including measuring intraocular pressure (IOP), optic disc cupping and visual field changes and group C of 30 patients of POAG under medical treatment by topical anti-glaucomatous drugs. Serum ceruloplasmin, superoxide dismutase, malondialdehyde and catalase activity were measured in all groups, statistical analysis of the data was performed. Results: In a comparison to group A of control, serum ceruloplasmin decreased significantly in group B of untreated POAG (20.95 ± 6.01) mg-dl and in group C of POAG under treatment (22.15 ± 6.14) mg-dl (P < 0.001), and there was no statistically difference between group B and C (P > 0.05). Also, serum superoxide dismutase increased significantly in group B (2.23 ± 0.4) and in group C (2.19 ± 0.38) U-ml (P < 0.001), and there was no statistically difference between group B and C (P > 0.05). Serum malondialdehyde increased significantly in group B (3.82 ± 0.74) nmol-ml and in group C (3.55 ± 0.73) nmol-ml (P < 0.001) in a comparison to the control group A (2.23 ± 0.41) nmol-ml, and there was no statistically difference between group B and C (P > 0.05). Serum catalase decreased significantly in group B (17.97 ± 2.75) U-ml and in group C (18.75 ± 2.33) U-ml in a comparison to the control group A (22.67 ± 3.05) U-ml (P < 0.001), and there was no statistically difference between group B How to cite this paper:

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Section: Discussionsupporting

confidence: 81%

The Role of Serum Ceruloplasmin and Oxidative Stress Markers in Primary Open Angle Glaucoma

Sharkh¹,

Nada²,

Moety³

et al. 2018

OJOph

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“…Unstable free radical species then attack cellular components causing damage to lipids, proteins, and DNA that can initiate a chain of reactions resulting in the onset of a variety of diseases, 17 including GON. [18][19][20][21] In fact, recent studies have suggested that oxidative damage constitutes an important pathologic step in inducing and maintaining the degeneration of the trabecular meshwork, optic nerve, and RGCs. Gherghel et al, for example, reported that glaucoma patients exhibit low levels of circulating glutathione, suggesting compromised oxidative defence.…”

Section: Introductionmentioning

confidence: 99%

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Yoshida

Ohguro

2013

Journal of Ocular Pharmacology and Therapeutics

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Purpose: Our recent study, which involved a randomized, placebo-controlled, double-masked 24-month trial (Ophthalmologica 2012;228:26-35), revealed that oral administration of black currant anthocyanins (BCACs) slowed down the visual field deterioration and elevation of ocular blood flow of open-angle glaucoma (OAG). To elucidate the underlying mechanisms of these BCAC-induced effects, as possible factors affecting glaucomatous optic neuropathy, changes of serum endothelin-1 (ET-1), nitric oxide (NO), and antioxidative activities were examined in the present study. Methods: From among patients with OAG who participated in the randomized, placebo-controlled, doublemasked trial, serum specimens were obtained from BCAC-treated (n = 19) or placebo-treated (n = 19) patients at baseline and every 6 months. Healthy volunteers (n = 20) with age and gender matching the patients were used as a control. Serum ET-1 concentration, [NO 2 -] and [NO 2 -+ NO 3 -] levels, advanced oxidation protein products (AOPP), and antioxidant activities were measured by using commercially available kits. Results: At the trial baseline, serum ET-1 concentrations were significantly lower in patients with OAG (BCACs, 3.18 -1.06 pg/mL; placebo, 3.44 -0.84 pg/mL) than those in healthy volunteers (4.38 -1.03 pg/mL) (one-way analysis of variance and a Tukey's multiple comparison post hoc test, P < 0.05). Upon administration of BCACs, serum ET-1 concentrations increased to the levels of those in healthy volunteers during the 24-month period. In contrast, those of placebo-treated patients remained at lower levels (3.82 -1.14 pg/mL). While [NO 2 -] and [NO 2 -+ NO 3 -] levels, AOPP, and antioxidative activities of patients from both the BCACs and placebo groups showed comparable levels to those of healthy subjects at baseline, no significant changes were observed during the observational period in either the BCAC or placebo groups. Conclusions: Among the possible beneficial effects of BCACs toward visual field progression in patients with OAG, our present results suggest that BCACs caused normalization of serum ET-1 levels, and this may modulate ET-1-dependent regulation of the ocular blood hemodynamics.

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“…The Val isoform of SOD2 has been suggested that may lead to a decreased resistance against ROS produced in the mitochondria and to oxidative damage of proteins caused by less efficient SOD2 transport into the mitochondria [34]. Several studies suggested that a significant increase in oxidative stress may play a role in the pathogenesis of POAG [35,36].…”

Section: Discussionmentioning

confidence: 99%

Association of Superoxide Dismutase 2 Polymorphism Rs4880 and Open-Angle Glaucoma in a Greek Patients’ Cohort

Lavaris¹,

Gazouli²,

Kitsos³

et al. 2016

J Genet Syndr Gene Ther

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Purpose: Glaucoma is a multifactorial optic neuropathy and leading cause of visual impairment and blindness. Multigenic inheritance hypothesis is being investigated over the past decades and numerous mainly causative and synergic polymorphisms have been revealed. Aim of this study is to investigate whether superoxide dismutase 2 (SOD2) polymorphism rs4880 is associated with primary open angle glaucoma (POAG) in Greek population. Materials and method:This is a case control study of 106 POAG patients and 120 thoroughly examined, unrelated, healthy control subjects of Greek origin, surveyed for SOD2 polymorphism rs4880 and potential correlation to POAG.Results: SOD2 rs4880 polymorphism showed no statistically significant difference between POAG patients and healthy controls. Mean intraocular pressure (IOP) of both eyes of the heterozygous (T/C) group was found significantly higher than in homozygous (T/T) group (19.13 ± 0.60 vs. Conclusion:Our study did not find any significant association between SOD2 rs4880 polymorphism and POAG. Mean IOP of the polymorphic (C) allele carriers was found significantly higher than in homozygous (T/T) group. As we cannot reject the possibility that oxidative stress might be a crucial factor for the POAG development further studies may be needed to confirm the importance of SOD2 gene in POAG pathogenesis.

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Oxidative Stress Markers in Patients with Primary Open-Angle Glaucoma

Abstract: Increased levels of aqueous humor GPO, SOD, and MDA may be associated with POAG. In addition, they may be useful antioxidant enzyme levels in aqueous humor of POAG patients as a result of glaucoma disease and not a cause.

Cited by 122 publications

References 15 publications

The Role of Serum Ceruloplasmin and Oxidative Stress Markers in Primary Open Angle Glaucoma

The Role of Serum Ceruloplasmin and Oxidative Stress Markers in Primary Open Angle Glaucoma

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Association of Superoxide Dismutase 2 Polymorphism Rs4880 and Open-Angle Glaucoma in a Greek Patients’ Cohort

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