Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Yoshida, Kaori; Ohguro, Ikuyo; Ohguro, Hiroshi

doi:10.1089/jop.2012.0198

Cited by 38 publications

(33 citation statements)

References 60 publications

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“…Serum levels of endothelin-1 in placebo-treated OAG patients remained low. The study did not find an effect of intake of blackcurrants on nitric oxide concentrations in the 38 included patients (Yoshida et al 2013).…”

Section: Nutrition With Antioxidative Propertiesmentioning

confidence: 71%

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The relation between dietary intake and glaucoma: a systematic review

Ramdas

2018

Acta Ophthalmologica

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Intake of selenium and iron may increase the risk of glaucoma, though, only few studies have been done on this topic. Nitric oxide present in other dark green leafy vegetables seems to have a beneficial effect on glaucoma. However, the evidence for an association of dietary intake with glaucoma is still not strong. More (longitudinal and randomized clinical trials) studies are required to make the presented findings clinically applicable.

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Section: Nutrition With Antioxidative Propertiesmentioning

confidence: 71%

“…The study did not find an effect of intake of blackcurrants on nitric oxide concentrations in the 38 included patients (Yoshida et al. ).…”

Section: Resultsmentioning

confidence: 97%

The relation between dietary intake and glaucoma: a systematic review

Ramdas

2018

Acta Ophthalmologica

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“…Black currant anthocyanins have been shown to normalise abnormal levels of serum concentrations of ET-1 in patients with glaucoma [298]. Food rich in flavanols, particularly cocoa, may improve endothelial function in general [299].…”

Section: Therapymentioning

confidence: 99%

The primary vascular dysregulation syndrome: implications for eye diseases

2013

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Vascular dysregulation refers to the regulation of blood flow that is not adapted to the needs of the respective tissue. We distinguish primary vascular dysregulation (PVD, formerly called vasospastic syndrome) and secondary vascular dysregulation (SVD). Subjects with PVD tend to have cold extremities, low blood pressure, reduced feeling of thirst, altered drug sensitivity, increased pain sensitivity, prolonged sleep onset time, altered gene expression in the lymphocytes, signs of oxidative stress, slightly increased endothelin-1 plasma level, low body mass index and often diffuse and fluctuating visual field defects. Coldness, emotional or mechanical stress and starving can provoke symptoms. Virtually all organs, particularly the eye, can be involved. In subjects with PVD, retinal vessels are stiffer and more irregular, and both neurovascular coupling and autoregulation capacity are reduced while retinal venous pressure is often increased. Subjects with PVD have increased risk for normal-tension glaucoma, optic nerve compartment syndrome, central serous choroidopathy, Susac syndrome, retinal artery and vein occlusions and anterior ischaemic neuropathy without atherosclerosis. Further characteristics are their weaker blood–brain and blood-retinal barriers and the higher prevalence of optic disc haemorrhages and activated astrocytes. Subjects with PVD tend to suffer more often from tinnitus, muscle cramps, migraine with aura and silent myocardial ischaemic and are at greater risk for altitude sickness. While the main cause of vascular dysregulation is vascular endotheliopathy, dysfunction of the autonomic nervous system is also involved. In contrast, SVD occurs in the context of other diseases such as multiple sclerosis, retrobulbar neuritis, rheumatoid arthritis, fibromyalgia and giant cell arteritis. Taking into consideration the high prevalence of PVD in the population and potentially linked pathologies, in the current article, the authors provide recommendations on how to effectively promote the field in order to create innovative diagnostic tools to predict the pathology and develop more efficient treatment approaches tailored to the person.

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“…Additionally, Yoshida and colleagues report that administration of anthocyanins to glaucoma patients for 24 months led to a normalization of endothelin‐1 levels, and speculated that this could lead to increased ocular vasodilation and perfusion (Yoshida et al. ). Canter & Ernst () demonstrated an improvement in night vision with bilberry extract supplementation, thereby indicating its influence on ophthalmic function.…”

Section: Introductionmentioning

confidence: 99%