Oxidative stress markers at birth: Analyses of a neonatal population

Giuffrè, Mario; Rizzo, Manfredi; Scaturro, Giusi Maria; Pitruzzella, Alessandro; Gammazza, Antonella Marino; Cappello, Francesco; Corsello, Giovanni; Volti, Giovanni Li

doi:10.1016/j.acthis.2015.01.007

Cited by 24 publications

(13 citation statements)

References 29 publications

(27 reference statements)

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“…This finding may indicate a buffering role for oxidative stress by the placenta. Giuffrè et al found that GSH levels were increased in babies born by vaginal delivery, as well as being positively correlated to gestational age [22]. In this study, lower levels of GSH-Px were found in newborns compared with their mothers.…”

Section: Discussionsupporting

confidence: 55%

Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates

et al. 2017

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BackgroundOxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included in this study to assess the presence of oxidative stress biomarkers and their relationship with serum cytokine concentrations. Oxidative stress biomarkers and antioxidant enzymes were compared between the mother/offspring pairs. The presence of 27 cytokines was measured in maternal and cord blood samples. Analyses were initially performed between all mothers and newborns and later between normal weight and mothers with overweight and obesity, and diabetic/non-diabetic women.ResultsSignificant differences were found in biomarker concentrations between mothers and newborns. Additionally, superoxide-dismutase activity was higher in pre-pregnancy overweight mothers compared to those with normal weight. Activity for this enzyme was higher in neonates born from mothers with normal pregestational weight compared with their mothers. Nitrites in overweight/obese mothers were statistically lower than in their offspring. Maternal free fatty acids, nitrites, carbonylated proteins, malondialdehyde and superoxide dismutase predicted maternal serum concentrations of IL-4, IL-13, IP-10 and MIP-1β. Arginase activity in maternal plasma was related to decreased concentrations of IL-4 and IL-1β in cord arterial blood. Increased maternal malondialdehyde plasma was associated with higher levels of IL-6 and IL-7 in the offspring.ConclusionsOxidative stress biomarkers differ between mothers and offspring and can predict maternal and newborn cytokine concentrations, indicating a potential role for oxidative stress in foetal metabolic and immunologic programming. Moreover, maternal obesity and diabetes may affect maternal microenvironments, and oxidative stress related to these can have an impact on the placenta and foetal growth.

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Section: Discussionsupporting

confidence: 55%

Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates

et al. 2017

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“…However, the balance between the production and scavenging of ROS somehow shifts towards the formation of free radicals, which results in damage or death to the cells over time [Ray et al, ; Poljsak et al, ]. Therefore, the up‐regulation of oxidative stress‐, peroxiredoxin‐, and apoptosis‐related proteins is likely to be involved in the defense against oxidative stress induced by ROS [Tosaki and Edes, ; Chae et al, ; Giuffre et al, ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Human Mesenchymal Stem Cells Derived From Bone Marrow, Placenta, and Adipose Tissue as Sources of Cell Therapy

Jeon

Kim

Cho

et al. 2015

J of Cellular Biochemistry

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Various source-derived mesenchymal stem cells (MSCs) with multipotent capabilities were considered for cell therapeutics of incurable diseases. The applicability of MSCs depends on the cellular source and on their different in vivo functions, despite having similar phenotypic and cytological characteristics. We characterized MSCs from different sources, including human bone marrow (BM), placenta (PL), and adipose tissue (AT), in terms of the phenotype, surface antigen expression, differentiation ability, proteome reference map, and blood flow recovery in a hindlimb ischemic disease model. The MSCs exhibit different differentiation potentials depending on the cellular source despite having similar phenotypic and surface antigen expression. We identified approximately 90 differentially regulated proteins. Most up- or down-regulated proteins show cytoskeletal or oxidative stress, peroxiredoxin, and apoptosis roles according to their functional involvement. In addition, the PL-MSCs retained a higher therapeutic efficacy than the BM- and AT-MSCs in the hindlimb ischemic disease model. In summary, we examined differentially expressed key regulatory factors for MSCs that were obtained from several cellular sources and demonstrated their differentially expressed proteome profiles. Our results indicate that primitive PL-MSCs have biological advantages relative to those from other sources, making PL-MSCs a useful model for clinical applications of cell therapy.

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“…Giuffrè et al [ 72 ] stated that glutathione, lipid hydroperoxides, and heat shock protein chaperonin 60 in the newborn's serum might have functional and diagnostic significance for oxidative stress. There are some studies of the diagnosis of oxidative stress-related neonatal disease in both humans and animals.…”

Section: Diagnosis Of Oxidative Stress-related Neonatal Diseasementioning

confidence: 99%

Oxidative Stress Related Diseases in Newborns

Özsürekçi

Aykaç

2016

Oxidative Medicine and Cellular Longevity

154

111

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We review oxidative stress-related newborn disease and the mechanism of oxidative damage. In addition, we outline diagnostic and therapeutic strategies and future directions. Many reports have defined oxidative stress as an imbalance between an enhanced reactive oxygen/nitrogen species and the lack of protective ability of antioxidants. From that point of view, free radical-induced damage caused by oxidative stress seems to be a probable contributing factor to the pathogenesis of many newborn diseases, such as respiratory distress syndrome, bronchopulmonary dysplasia, periventricular leukomalacia, necrotizing enterocolitis, patent ductus arteriosus, and retinopathy of prematurity. We share the hope that the new understanding of the concept of oxidative stress and its relation to newborn diseases that has been made possible by new diagnostic techniques will throw light on the treatment of those diseases.

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Oxidative stress markers at birth: Analyses of a neonatal population

Cited by 24 publications

References 29 publications

Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates

Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates

Comparative Analysis of Human Mesenchymal Stem Cells Derived From Bone Marrow, Placenta, and Adipose Tissue as Sources of Cell Therapy

Oxidative Stress Related Diseases in Newborns

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