Oxidative stress involvement in psoriasis: a systematic review

Cannavò, Serafinella Patrizia; Riso, Gabriella; Casciaro, Marco; Salvo, Eleonora Di; Gangemi, Sebastiano

doi:10.1080/10715762.2019.1648800

Cited by 104 publications

(89 citation statements)

References 59 publications

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“…However, as already mentioned, maintaining the redox equilibrium is a multifactorial process of which GSTs are only a part, whose importance may vary depending on the interplay between all factors. It is well known that the GSTM1 null and the GSTT1 null genotypes are frequent in the general population, but with significant worldwide variability [58][59][60], and their role and "relative weight" as risk factors for several dermatologic conditions may range from irrelevant to highly significant, depending on the population studied [10,11,[58][59][60][61][62][63][64][65]. Similar considerations may be applied to GSTP1 polymorphisms [66,67].…”

Section: Discussionmentioning

confidence: 99%

“…Over time, accumulation of ROS eventually exceeds the defense capacity of the antioxidant system (AOS). This condition, defined oxidative stress (OS), plays a role in the pathogenesis of AD, as well as in other cutaneous and non-cutaneous diseases [10][11][12]. Atopic dermatitis is characterized by infiltration of inflammatory cells, such as lymphocytes, macrophages, eosinophils, and mast cells.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress and Atopic Dermatitis

et al. 2020

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Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects. Like in other chronic inflammatory diseases, oxidative stress plays an important pathogenetic role. We reviewed in vivo research studies on humans about oxidative stress and atopic dermatitis. Although sometimes contrasting, overall, they suggest that oxidative stress may have a significant role in atopic dermatitis, but our understanding is still incomplete, at least concerning in vivo data, because of limitations of available literature. Research consists of 33 papers published in 28 years, was not always performed on large study populations, represents a limited number of countries and ethnicities—not always in proportion to their size—and is scattered over multiple papers that, in the majority of cases, cannot be pooled and/or compared because many biomarkers were studied, in different tissues and with different methods. Further, larger studies appear warranted and necessary to shed more light on this aspect of atopic dermatitis, which is important not only to improve our understanding of this disease, but also for potential clinical and therapeutic implications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Atopic Dermatitis

et al. 2020

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“…Different populations of activated leukocytes infiltrating skin lesions also lead to an increase in the level of local oxidants and cause a pro-inflammatory response, as well as oxidative modifications of proteins and lipids in skin cells, especially in keratinocytes [52,53]. Despite the evidence that oxidative stress occurs systemically and locally in psoriasis, many current treatments, to accelerate the removal of damaged epidermal cells, further increase oxidative stress, leading to their death [54]. This is particularly important for skin exposed to UV radiation, which leads to the mass production of singlet oxygen [25].…”

Section: Redox Conditions In Psoriatic Patient Keratinocytes Treated mentioning

confidence: 99%

Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris

Jarocka-Karpowicz

Biernacki

Wroński³

et al. 2020

Biomolecules

101

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Psoriasis is a chronic inflammatory skin disease characterized by dysregulated keratinocyte differentiation, but oxidative stress also plays an important role in the pathogenesis of this disease. Here, we examined the effect of cannabidiol (CBD), a phytocannabinoid with antioxidant and anti-inflammatory properties, on the redox balance and phospholipid metabolism in UVA/UVB-irradiated keratinocytes isolated from the skin of psoriatic patients or healthy volunteers. CBD accumulates mainly in membrane keratinocytes, especially from patients with psoriasis. This phytocannabinoid reduces the redox imbalance observed in the UV-irradiated keratinocytes of healthy subjects. It does so by decreasing reactive oxygen species (ROS) generation, increasing the Trx-dependent system efficiency, and increasing vitamin A and E levels. Consequently, a reduction in lipid peroxidation products, such as 8-isoprostanes and 4-hydroxynonenal, was also observed. Moreover, CBD modifies redox balance and lipid peroxidation in psoriatic patient keratinocytes following UV-irradiation. Interestingly, these changes are largely in the opposite direction to the case of keratinocytes from healthy subjects. CBD also regulates metabolic changes by modulating the endocannabinoid system that is disturbed by psoriasis development and UV irradiation. We observed a decrease in anandamide level in the UV-irradiated keratinocytes of healthy controls following CBD treatment, while in keratinocytes from patients treated with CBD, anandamide level was increased. However, the level of palmitoylethanolamide (PEA) was decreased in both groups treated with CBD. We further demonstrate that CBD increases CB1 receptor expression, primarily in the keratinocytes of patients, and increases CB2 receptor expression in both the psoriatic and control groups. However, CBD decreases CB2 receptor expression in UV-irradiated keratinocytes taken from patients. The UV- and psoriasis-induced activity of transmembrane transporters (Multidrug-Resistance (MDR) and breast cancer resistance protein (BCRP)) is normalized after CBD treatment. We conclude that CBD partially reduces oxidative stress in the keratinocytes of healthy individuals, while showing a tendency to increase the oxidative and inflammatory state in the keratinocytes of patients with psoriasis, especially following UV-irradiation.

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“…Psoriasis is a chronic inflammatory autoimmune disease of the skin and joints. Its pathogenesis is thought to include interactions between genetic factors (for example, the HLACw6 and HLACw7 tissue compatibility complex alleles) and environmental factors such as bacterial or viral infections, injuries, and stress [ 1 ]. Psoriasis is mediated by T cells, dendritic cells, neutrophils, and other leukocytes.…”

Section: Introductionmentioning

confidence: 99%

Reduced Proteasome Activity and Enhanced Autophagy in Blood Cells of Psoriatic Patients

Karabowicz

Wroński²,

Ostrowska

et al. 2020

IJMS

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Psoriasis is a skin disease that is accompanied by oxidative stress resulting in modification of cell components, including proteins. Therefore, we investigated the relationship between the intensity of oxidative stress and the expression and activity of the proteasomal system as well as autophagy, responsible for the degradation of oxidatively modified proteins in the blood cells of patients with psoriasis. Our results showed that the caspase-like, trypsin-like, and chymotrypsin-like activity of the 20S proteasome in lymphocytes, erythrocytes, and granulocytes was lower, while the expression of constitutive proteasome and immunoproteasome subunits in lymphocytes was increased cells of psoriatic patients compared to healthy subjects. Conversely, the expression of constitutive subunits in erythrocytes, and both constitutive and immunoproteasomal subunits in granulocytes were reduced. However, a significant increase in the autophagy flux (assessed using LC3BII/LC3BI ratio) independent of the AKT pathway was observed. The levels of 4-HNE, 4-HNE-protein adducts, and proteins carbonyl groups were significantly higher in the blood cells of psoriatic patients. The decreased activity of the 20S proteasome together with the increased autophagy and the significantly increased level of proteins carbonyl groups and 4-HNE-protein adducts indicate a proteostatic imbalance in the blood cells of patients with psoriasis.

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Oxidative stress involvement in psoriasis: a systematic review

Cited by 104 publications

References 59 publications

Oxidative Stress and Atopic Dermatitis

Oxidative Stress and Atopic Dermatitis

Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris

Reduced Proteasome Activity and Enhanced Autophagy in Blood Cells of Psoriatic Patients

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