Oxidative stress, inflammatory cytokines and body composition of master athletes: The interplay

Aguiar, Samuel da Silva; Sousa, Caio Victor; Deus, Lysleine Alves; Rosa, Thiago Santos; Sales, Marcelo Magalhães; Neves, Rodrigo Vanerson Passos; Barbosa, Lucas Pinheiro; Santos, Patrick Anderson; Campbell, Carmen S.; Simões, Herbert Gustavo

doi:10.1016/j.exger.2019.110806

Cited by 28 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In reporting lower concentrations of inflammatory mediators in a trained group of older adults (Cohen’s d >0.75; large effect for IL-6 and hsCRP), our findings support those of Aguiar et al (2020) , who reported middle-age masters athletes had lower IL-6 and TNF-α than an age-matched control group. These findings were observed in participants ~46–52year of age, and the present study extends these findings into sexagenarians (termed the “young-old”), supporting the contention that exercise habits modify inflammation, potentially through indirect adipose tissue reduction.…”

Section: Discussionsupporting

confidence: 85%

Short-Term and Lifelong Exercise Training Lowers Inflammatory Mediators in Older Men

et al. 2021

View full text Add to dashboard Cite

Increased basal low-grade inflammation is observed with advancing age, which is augmented by physical inactivity. However, data regarding the influence of lifelong exercise training and particularly high-intensity interval training (HIIT) on inflammatory mediators in older men are scarce. Therefore, we examined effects of 6weeks of aerobic preconditioning followed by 6weeks of HIIT on inflammatory mediators [interleukin (IL)-6, homocysteine, and high-sensitivity C-reactive protein (hsCRP)] in previously sedentary older men (SED) and masters athletes (LEX). Further, we investigated whether SED exhibited greater basal inflammatory biomarkers compared to LEX. Twenty-two men (aged 62±2years) participated in the SED group, while 17 age-matched LEX men (aged 60±5years) also participated as a positive comparison group. In SED, preconditioning (P=0.030, d=0.34) and HIIT (P=0.030, d=0.48) caused a reduction in IL-6 compared to enrollment. SED homocysteine did not change throughout (P>0.57; d<0.26), while the decrease in hsCRP after preconditioning (P=0.486, d=0.25) and after HIIT (P=0.781, d=0.23) compared to enrollment was small. HIIT did not influence IL-6 or hsCRP in LEX (all P>0.42; d<0.3). Homocysteine increased from enrollment to post-HIIT in LEX (P=0.144, d=0.83), but all other perturbations were trivial. IL-6 and hsCRP were greater in SED than LEX throughout the investigation (all P<0.029; d>0.72), but homocysteine was not different (all P >0.131; d<0.41). Results of this study suggest moderate-intensity aerobic exercise and HIIT lowers IL-6 (and possible hsCRP) in previously sedentary older men. Moreover, lifelong exercise is associated with reduced concentrations of some inflammatory biomarkers in older males, and therefore, physical activity, rather than age per se, is implicated in chronic low-grade inflammation. Moreover, physical inactivity-induced inflammation may be partly salvaged by short-term exercise training.

show abstract

Section: Discussionsupporting

confidence: 85%

Short-Term and Lifelong Exercise Training Lowers Inflammatory Mediators in Older Men

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Those previous findings demonstrated the relevance of regulating inflammatory status for general health. This regulation was found by Aguiar et al [19], verifying lower inflammatory cytokines and markers of oxidative stress in master athletes, but to the best of our knowledge, kidney function has not yet been analyzed in this population. In this regard, the present study contributes to the understanding of the biomarkers related to renal integrity in master athletes performing either sprint or endurance training over life, and the possible variables associated with the exercise-preserved renal function.…”

Section: Discussionsupporting

confidence: 65%

“…Exercise training stands as an important regulator of these conditions, improving the anti-inflammatory profile, and playing a significant role in the regulation of redox balance [14][15][16][17][18][19]. In fact, this can be seen in master athletes, who represent a healthier aging group due to their training and lifestyle regimes that, for decades,…”

Section: Introductionmentioning

confidence: 99%

Age-related Decline in Renal Function is Attenuated in Master Athletes

et al. 2021

Self Cite

View full text Add to dashboard Cite

This study analyzed the kidney function and biomarkers of health in lifelong-trained sprinters and endurance runners, and compared them to untrained aged-matched and young controls. Sixty-two men (21–66 yr.) were recruited and allocated as master athletes from sprints (n=25), master athletes from endurance events (n=8), untrained middle-aged (n=14) and young controls (n=15). Participants underwent anamnesis, anthropometric measures and blood sampling for biochemical analyses of klotho, FGF23 and estimated glomerular filtration rate. Master sprinters presented better kidney function in relation to endurance athletes and their untrained peers (P<0.0001). A number of biochemical variables were observed that negatively (i. e., GDF-15, TGF-Beta, IL-18) or positively (i. e., klotho/FGF23 ratio and sestrin-2) correlated with eGFR. Sestrin-2 presented the strongest association with eGFR (r=0.5, P=0.03). Results also revealed that lifelong-trained individuals presented the highest probability of having better values for cystatin C and thus an estimated glomerular filtration rate that was 37–49% higher than untrained peers. Master sprinters presented better kidney function in relation to endurance athletes and middle-aged untrained peers. Sestrin-2 may play a role in exercise-induced kidney function protection.

show abstract

“…They also have a preserved proportion of naive CD4+ cells without senescent T-cells accumulation than age-matched sedentary people (Minuzzi et al, 2018). This may at least partly be due to their lower level of systemic inflammation and oxidative damage (Aguiar et al, 2019(Aguiar et al, , 2020. It is to be expected that such a profile will significantly enhance the ability of master athletes to combat infections, including COVID-19, above that seen in their unfit age-matched peers (Figure 1).…”

Section: Leukocyte Telomere Length Immunosenescence and Survival Frmentioning

confidence: 99%

Does Longer Leukocyte Telomere Length and Higher Physical Fitness Protect Master Athletes From Consequences of Coronavirus (SARS-CoV-2) Infection?

Simões

Rosa

Sousa

et al. 2020

Front. Sports Act. Living

Self Cite

View full text Add to dashboard Cite

THE SARS-CoV-2 INFECTION AND IMMUNE SYSTEM We are waging a war against a deadly virus that has already resulted in the death of thousands of people worldwide (Burn-Murdoch, 2020). Against this invisible enemy, we have a sophisticated defense: our immune system. After infection, leukocytes proliferate and send signals to other immune cells to replicate and differentiate and, hence, increasing recruits to the army to combat the invaders in an attempt to ensure survival (Immunology, 2013).

show abstract

Oxidative stress, inflammatory cytokines and body composition of master athletes: The interplay

Cited by 28 publications

References 29 publications

Short-Term and Lifelong Exercise Training Lowers Inflammatory Mediators in Older Men

Short-Term and Lifelong Exercise Training Lowers Inflammatory Mediators in Older Men

Age-related Decline in Renal Function is Attenuated in Master Athletes

Does Longer Leukocyte Telomere Length and Higher Physical Fitness Protect Master Athletes From Consequences of Coronavirus (SARS-CoV-2) Infection?

Contact Info

Product

Resources

About