Age-related Decline in Renal Function is Attenuated in Master Athletes

Rosa, Thiago Santos; Corrêa, Hugo de Luca; Barbosa, Lucas Pinheiro; Santos, Patrick Anderson; Leite, Patrício Lopes de Araújo; Aguiar, Samuel da Silva; Deus, Lysleine Alves; Maciel, Larissa Alves; Neves, Rodrigo Vanerson Passos; Simões, Herbert Gustavo

doi:10.1055/a-1332-1594

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Although our meta-analysis was comprehensive and included multiple studies, some other studies that did not meet the inclusion criteria are also in agreement with our conclusions (Supplementary Table 1). In summary, the excluded studies demonstrated that master athletes present higher levels of S-Klotho in comparison to non-athletes 44,45 . This fact could be associated with physical activity levels, higher muscle mass, increased fat oxidation, low cardiometabolic risk, and muscle strength [46][47][48][49][50][51][52] .…”

Section: Discussionmentioning

confidence: 79%

Klotho, much more than an anti-aging protein, an emerging exerkine: A systematic review and meta-analysis

Corrêa

Raab

Araújo

et al. 2022

Preprint

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Background: Klotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise increases Klotho levels, regardless of the condition or intervention, shedding some light on this anti-aging protein as an emergent and promising exerkine. Objective: Development of a systematic review and meta-analysis in order to verify the role of different exercise training protocols on the levels of circulating soluble Klotho (S-Klotho) protein. Data sources: A systematic search of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE through PubMed, EMBASE, CINAHL, CT.gov, and PEDro. Eligibility criteria: Randomized and quasi-randomized controlled trials that investigated effects of exercise training on S-Klotho levels. Results: We included 12 reports in the analysis, comprising 621 participants with age ranging from 30 to 65 years old. Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge’ g [95%CI] 1.3 [0.69 – 1.90]; P < 0.0001). Moreover, exercise training increases S-Klotho values regardless of the health condition of the individual or the exercise intervention, with the exception of combined aerobic + resistance training. Furthermore, protocol duration and volume seem to influence S-Klotho concentration, since the effect of the meta-analysis changes when subgrouping these variables. Conclusion: Altogether, circulating S-Klotho protein is altered after chronic exercise training and it might be considered an exerkine. However, this effect may be influenced by different training configurations, including protocol duration, volume, and intensity.

show abstract

Section: Discussionmentioning

confidence: 79%

Klotho, much more than an anti-aging protein, an emerging exerkine: A systematic review and meta-analysis

Corrêa

Raab

Araújo

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although our meta-analysis was comprehensive and included multiple studies, some other studies that did not meet the inclusion criteria are also in agreement with our conclusions (Supplementary Table 1). In summary, the excluded studies demonstrated that master athletes present higher levels of S-Klotho in comparison to nonathletes 44,45 . This fact could be associated with physical activity levels, higher muscle mass, increased fat oxidation, low cardiometabolic risk, and muscle strength [46][47][48][49][50][51][52] .…”

Section: Discussionmentioning

confidence: 80%

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine

Corrêa

Raab²,

Araújo³

et al. 2022

Sci Rep

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Klotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise increases Klotho levels, regardless of the condition or intervention, shedding some light on this anti-aging protein as an emergent and promising exerkine. Development of a systematic review and meta-analysis in order to verify the role of different exercise training protocols on the levels of circulating soluble Klotho (S-Klotho) protein. A systematic search of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE through PubMed, EMBASE, CINAHL, CT.gov, and PEDro. Randomized and quasi-randomized controlled trials that investigated effects of exercise training on S-Klotho levels. We included 12 reports in the analysis, comprising 621 participants with age ranging from 30 to 65 years old. Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge’ g [95%CI] 1.3 [0.69–1.90]; P < 0.0001). Moreover, exercise training increases S-Klotho values regardless of the health condition of the individual or the exercise intervention, with the exception of combined aerobic + resistance training. Furthermore, protocol duration and volume seem to influence S-Klotho concentration, since the effect of the meta-analysis changes when subgrouping these variables. Altogether, circulating S-Klotho protein is altered after chronic exercise training and it might be considered an exerkine. However, this effect may be influenced by different training configurations, including protocol duration, volume, and intensity.

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“…A cohort study of master sprint athletes showed that they had better renal function, lower degree of inflammation, and higher Klotho levels than healthy but untrained age-matched peers [ 234 ]. This is in agreement with other studies that found higher S-Klotho levels in athletes compared to healthy controls [ 235 ] and an increased level with moderate-intensity exercise training [ 236 ].…”

Section: Effects Of Physical Activity and Exercise On Human Biology In View Of Covid-19mentioning

confidence: 99%

Potential Physiological and Cellular Mechanisms of Exercise That Decrease the Risk of Severe Complications and Mortality Following SARS-CoV-2 Infection

Jakobsson

Cotgreave

Furberg

et al. 2021

Sports

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The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has unmasked mankind’s vulnerability to biological threats. Although higher age is a major risk factor for disease severity in COVID-19, several predisposing risk factors for mortality are related to low cardiorespiratory and metabolic fitness, including obesity, cardiovascular disease, diabetes, and hypertension. Reaching physical activity (PA) guideline goals contribute to protect against numerous immune and inflammatory disorders, in addition to multi-morbidities and mortality. Elevated levels of cardiorespiratory fitness, being non-obese, and regular PA improves immunological function, mitigating sustained low-grade systemic inflammation and age-related deterioration of the immune system, or immunosenescence. Regular PA and being non-obese also improve the antibody response to vaccination. In this review, we highlight potential physiological, cellular, and molecular mechanisms that are affected by regular PA, increase the host antiviral defense, and may determine the course and outcome of COVID-19. Not only are the immune system and regular PA in relation to COVID-19 discussed, but also the cardiovascular, respiratory, renal, and hormonal systems, as well as skeletal muscle, epigenetics, and mitochondrial function.

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Age-related Decline in Renal Function is Attenuated in Master Athletes

Cited by 4 publications

References 35 publications

Klotho, much more than an anti-aging protein, an emerging exerkine: A systematic review and meta-analysis

Klotho, much more than an anti-aging protein, an emerging exerkine: A systematic review and meta-analysis

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine

Potential Physiological and Cellular Mechanisms of Exercise That Decrease the Risk of Severe Complications and Mortality Following SARS-CoV-2 Infection

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