Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells

Zhou, Wenjing; Xu, Gang; Wang, Yunqiu; Xu, Ziao; Liu, Xiaofei; Xu, Xia; Ren, Guijie; Tian, Keli

doi:10.1080/15384101.2016.1252882

Cited by 55 publications

(40 citation statements)

References 42 publications

(41 reference statements)

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“…Moreover, CAFs positively influence the proliferation and metabolism of cancer cells through oxidative stress, which induces the autophagy pathway [69]. CAFs can also serve as nutrients for cancer cells, as oxidation of CAFs offers nutrients such as ketone and cytokines, which mediate mitochondrial biogenesis and autophagy, in nearby cancer cells [70,71].…”

Section: Cancer-associated Fibroblast (Cafs)mentioning

confidence: 99%

Tumor microenvironment complexity and therapeutic implications at a glance

et al. 2020

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The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to increase the multidrug resistance ending in cancer cell progression and metastasis. The reciprocal cell-cell/ECM interaction and tumor cell hijacking of non-malignant cells force stromal cells to lose their function and acquire new phenotypes that promote development and invasion of tumor cells. Understanding the underlying cellular and molecular mechanisms governing these interactions can be used as a novel strategy to indirectly disrupt cancer cell interplay and contribute to the development of efficient and safe therapeutic strategies to fight cancer. Furthermore, the tumor-derived circulating materials can also be used as cancer diagnostic tools to precisely predict and monitor the outcome of therapy. This review evaluates such potentials in various advanced cancer models, with a focus on 3D systems as well as lab-on-chip devices.

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Section: Cancer-associated Fibroblast (Cafs)mentioning

confidence: 99%

Tumor microenvironment complexity and therapeutic implications at a glance

et al. 2020

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“…A positive influence of fibroblasts on cancer cell growth is well documented, with, eg, enhanced growth rates for both fibroblasts and colon cancer cell lines in cocultures, as well as enhanced growth rates of head and neck squamous cell carcinoma (HNSCC) cells and breast carcinoma cells . Similarly, primary patient‐derived AML cells survive and proliferate better in coculture with mouse stromal cells or human MSCs .…”

Section: Part Ii: the Role Of Autophagy In The Tumor Microenvironmentmentioning

confidence: 99%

“…Similarly, primary patient‐derived AML cells survive and proliferate better in coculture with mouse stromal cells or human MSCs . In cocultures, fibroblasts were characterized by elevated levels of autophagy as, eg, evidenced by the accumulation of LC3‐positive vesicles . Importantly, inhibition of autophagy markedly attenuated the beneficial impact of fibroblast in such cocultures.…”

Section: Part Ii: the Role Of Autophagy In The Tumor Microenvironmentmentioning

confidence: 99%

“…In many cases, the positive effect of fibroblasts on cancer cell growth was retained when cells were cultured in the absence of direct cell‐cell contact or when the conditioned medium of fibroblasts was used . In the latter case, the conditioned medium of CAFs outperformed that of normal fibroblasts .…”

Section: Part Ii: the Role Of Autophagy In The Tumor Microenvironmentmentioning

confidence: 99%

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The multifaceted role of autophagy in cancer and the microenvironment

Folkerts

Hilgendorf

Vellenga

et al. 2018

Medicinal Research Reviews

151

130

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Autophagy is a crucial recycling process that is increasingly being recognized as an important factor in cancer initiation, cancer (stem) cell maintenance as well as the development of resistance to cancer therapy in both solid and hematological malignancies. Furthermore, it is being recognized that autophagy also plays a crucial and sometimes opposing role in the complex cancer microenvironment. For instance, autophagy in stromal cells such as fibroblasts contributes to tumorigenesis by generating and supplying nutrients to cancerous cells. Reversely, autophagy in immune cells appears to contribute to tumor‐localized immune responses and among others regulates antigen presentation to and by immune cells. Autophagy also directly regulates T and natural killer cell activity and is required for mounting T‐cell memory responses. Thus, within the tumor microenvironment autophagy has a multifaceted role that, depending on the context, may help drive tumorigenesis or may help to support anticancer immune responses. This multifaceted role should be taken into account when designing autophagy‐based cancer therapeutics. In this review, we provide an overview of the diverse facets of autophagy in cancer cells and nonmalignant cells in the cancer microenvironment. Second, we will attempt to integrate and provide a unified view of how these various aspects can be therapeutically exploited for cancer therapy.

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“…Fibroblasts existing in the tumor microenvironment positively influenced the metabolism of colorectal cancer cells through neighboring tumor cells that induced autophagy. 40 Further research therefore remains to be tested whether FKB could also induce autophagy in tumor stromal cells and elucidate the relationship between FKB and the tumor microenvironment. Flavokawain-treated cells formed more fragmented mitochondria, whereas untreated cells formed tubular mitochondria, indicating alterations in the fusion-to-fission process in FKB-treated cells.…”

Section: Flavokawain Induces Cytoprotective Autophagy In Tca Cells mentioning

confidence: 99%

Adenosine 5'‐monophosphate‐activated protein kinase‐dependent mTOR pathway is involved in flavokawain B‐induced autophagy in thyroid cancer cells

Liu

Sha

et al. 2018

Cancer Science

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Flavokawain B (FKB), a natural kava chalcone, shows potent antitumor activity in various types of cancer, although the mechanism of action remains unclear. In this study, we report that FKB has profound effects on the metabolic state of human thyroid cancer (TCa) cells, leading to high autophagy flux through upregulation of AMP‐activated protein kinase, which in turn inhibits mTOR and activates Beclin‐1 in TCa cells. We further report that the autophagy induced by FKB plays a prosurvival role in TCa cells both in vitro and in vivo. In conclusion, our findings provide evidence that combination treatment with FKB and pharmacological autophagy inhibitors will be a potential therapeutic strategy for the treatment of TCa.

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Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells

Cited by 55 publications

References 42 publications

Tumor microenvironment complexity and therapeutic implications at a glance

Tumor microenvironment complexity and therapeutic implications at a glance

The multifaceted role of autophagy in cancer and the microenvironment

Adenosine 5'‐monophosphate‐activated protein kinase‐dependent mTOR pathway is involved in flavokawain B‐induced autophagy in thyroid cancer cells

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