Oxidative stress in radiology staff

Malekirad, Ali Akbar; Ranjbar, Akram; Rahzani, Kobra; Pilehvarian, Ali Asghar; Rezaie, Ali; Zamani, Mohammad Jafar; Abdollahi, Mohammad

doi:10.1016/j.etap.2005.01.005

Cited by 40 publications

(28 citation statements)

References 24 publications

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“…Our results agree with those obtained by Türkan et al (2005), who observed a significant increase in plasma and erythrocyte SOD activity in workers in intensive care units compared to personnel exposed to the effects of volatile anesthetics. Malekirad et al (2005a) found significantly a higher concentration of total antioxidant capacity (TAC) in radiology staff; however, these authors observed that TAC was lower in operating room personnel (Malekirad et al 2005b).…”

Section: Discussionmentioning

confidence: 71%

Relationship between oxidative and occupational stress and aging in nurses of an intensive care unit

Casado

Castellanos

López‐Fernández

et al. 2008

AGE

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Stressful conditions lead to formation of excessive reactive oxygen species (ROS) and cause oxidative stress and aging. The aim of this study was to determine superoxide dismutase (SOD) and catalase (CAT) activity, and malondialdehyde (MDA) levels in nurses of a hospital intensive care unit according to demographic and occupational parameters, and to analyse the relationship with aging. Thirty-two nurses working in an intensive care unit and 35 aged-matched healthy individuals of both sexes as a control group were surveyed. No significant variations with respect to sex were detected in SOD, CAT, MDA and burnout levels. MDA levels increased with age in both the control group and the nurses, and we observed significant differences in MDA levels between the control group and nurses for all age groups. Significant variations in MDA levels were detected between single (286.12±8.41) and married (318.82±6.02), people, between those who frequently practice some kind of sport (281.41±7.32) and those who never participate in sport (298.24±8.11) ,and between those who frequently eat fruit and greens (289.75±8.41) and those who never eat them (315.12± 7.21). Significant differences were detected between smokers and nonsmokers in SOD, CAT and MDA, but not for alcohol, coffee, tea or cola consumption. Higher SOD activity and MDA levels were detected in nurses on evening and night shifts (P<0.01); these nurses also scored significantly higher on burnout subscales. These results suggest that: (1) occupational stress increases oxidative stress levels as a response to elevated ROS generation; (2) occupational stress increases MDA levels as a response to an elevation in free radical generation and can lead to aging; (3) working evening and night shifts increases oxidative and burnout levels. It is evident that preventive changes in job conditions and lifestyle are necessary to improve the quality of life of nurses who work in intensive care units.

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Section: Discussionmentioning

confidence: 71%

Relationship between oxidative and occupational stress and aging in nurses of an intensive care unit

Casado

Castellanos

López‐Fernández

et al. 2008

AGE

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“…seems to be due to its bioactive antioxidant components, especially RA and flavonoids. In recent years the importance of oxidative stress in the pathophysiology of many human disorders has been highlighted (35–44), thus use of this plant as a dietary supplement is highly recommended (45,46). Trials to establish efficacy and optimum dosage of the present herbal product for treating human chronic diseases with pathophysiology of oxidative stress are essential.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Activity of Iranian Echium amoenum Fisch & C.A. Mey Flower Decoction in Humans: A cross‐sectional Before/After Clinical Trial

Ranjbar

Khorami

Safarabadi

et al. 2000

Evidence-Based Complementary and Alternative Medicine

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Medicinal plants are recognized as sources of natural antioxidants that can protect from biological system oxidative stress. The present cross-sectional before/after clinical trial was carried out to investigate the antioxidant properties of the decoction of the flowers of Echium amoenum Fisch & C.A. Mey in humans. A group of 38 healthy subjects was invited to use the E. amoenum (7 mg kg−1) twice daily for 14 days. Blood samples before and after entering the study were measured for lipid peroxidation level (LPO), total antioxidant capacity (TAC) and total thiol (SH) molecules. A significant reduction of blood LPO (24.65 ± 11.3 versus 19.05 ± 9.7, P = 0.029) was observed after 14 days of E. amoenum consumption. Blood TAC (1.46 ± 0.51 versus 1.70 ± 0.36, P = 0.018) and total thiol molecules (0.49 ± 0.11 versus 0.56 ± 0.12, P = 0.001) increased after 14 days of E. amoenum consumption. In conclusion, this antioxidative stress potential of E. amoenum may be due to its bioactive antioxidant components, especially rosmarinic acid and flavonoids. In recent years the importance of oxidative stress in the pathophysiology of many human disorders has been confirmed, thus use of this plant as a dietary supplement is highly recommended.

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“…Oxidative stress appears when there is an imbalance between the production and removal of ROS. Acute or chronic exposure to ionising radiation results in immediate formation of free radicals in living organisms leading to oxidative damage to DNA, proteins and lipids [29][30][31]. Also, oestrogenic compounds appear to produce ROS, especially hydrogen peroxide, at a level that disrupts DNA structure significantly in spermatozoa and in peripheral blood lymphocytes [32,33].…”

Section: Discussionmentioning

confidence: 99%

Combined action of X-rays and nonylphenol on mouse sperm

Dobrzyńska

2011

Open Life Sciences

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The aim of this study was to assess the effects of 2-weeks’ X-ray and/or nonylphenol (NP) exposure on male mice’s sperm count and quality. Pzh:SFIS mice were exposed to X-rays (0.05 Gy, 0.10 Gy, 0.20 Gy) or to nonylphenol (25 mg/kg bw, 50 mg/kg bw, 100 mg/kg bw) or to both agents (0.05 Gy + 25 mg/kg bw NP, 0.10 Gy + 50 mg/kg bw NP). At 24 h and 5 weeks after the end of exposure the sperm count, morphology and frequency of DNA damage in the male germ cells were estimated. Each agent alone diminished sperm count and morphology. The dose of 0.05 Gy of X-rays decreased the frequency of DNA damage. Combined exposure to lower doses of both agents significantly improved sperm morphology and decreased the level of DNA damage compared to one agent alone. Combined exposure to higher doses reduced the frequency of DNA damage compared to the effect of the appropriate dose of NP. Results of combined exposure to low doses of both agents suggest that 0.05 Gy of X-rays stimulate the DNA damagecontrol system and in consequence repair of DNA caused by X-rays and NP. It may be correlated with increased antioxidant capacity.

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Oxidative stress in radiology staff

Cited by 40 publications

References 24 publications

Relationship between oxidative and occupational stress and aging in nurses of an intensive care unit

Relationship between oxidative and occupational stress and aging in nurses of an intensive care unit

Antioxidant Activity of Iranian Echium amoenum Fisch & C.A. Mey Flower Decoction in Humans: A cross‐sectional Before/After Clinical Trial

Combined action of X-rays and nonylphenol on mouse sperm

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