Antioxidant Activity of Iranian Echium amoenum Fisch &amp; C.A.  Mey Flower Decoction in Humans: A cross‐sectional Before/After Clinical Trial

Ranjbar, Akram; Khorami, Sara; Safarabadi, Mehdi; Shahmoradi, Amene; Malekirad, Ali Akbar; Vakilian, Katyon; Mandegary, Ali; Abdollahi, Mohammad

doi:10.1093/ecam/nel031

Cited by 67 publications

(59 citation statements)

References 31 publications

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“…Oxidation products have been confirmed to increase peripheral neuropathy and damage Schwann cells (Vincent et al, 2004). Many Chinese traditional herbs have demonstrated natural anti-oxidative actions (Ranjbar et al, 2006). In this study, BYHWD exhibited anti-oxidative activity and protected H 2 O 2 damaged Schwann cells.…”

Section: Discussionmentioning

confidence: 55%

Neuroprotective effects of Buyang Huanwu decoction against hydrogen peroxide induced oxidative injury in Schwann cells

Yang

Gao

Shen

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 55%

Neuroprotective effects of Buyang Huanwu decoction against hydrogen peroxide induced oxidative injury in Schwann cells

Yang

Gao

Shen

et al. 2011

Journal of Ethnopharmacology

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“…20 The total thiol molecule (TTM) capacity was expressed as nmol per mg of protein in samples. The protein content of the samples was measured according to Lowry et al 19 …”

Section: Measurement Of Total Thiol Moleculesmentioning

confidence: 99%

Comparative Protective Effect of Hawthorn Berry Hydroalcoholic Extract, Atorvastatin, and Mesalamine on Experimentally Induced Colitis in Rats

Malekinejad

Shafie-Irannejad

Hobbenaghi

et al. 2013

Journal of Medicinal Food

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The protective effect of hydroalcoholic extract of hawthorn berries (HBE) on acetic acid (AA)-induced colitis in rats was investigated. Forty-two Wistar rats were divided into seven groups, including control and test groups (n = 6). The control animals received saline, and the test animals were treated with saline (sham group), mesalamine (50 mg/kg; M group), atorvastatin (20 mg/kg; A group), HBE (100 mg/kg; H group), mesalamine and HBE (HM group), or atorvastatin plus HBE (HA group), 3 days before and a week after colitis induction. Colitis was induced by administration of 1 mL AA (4%) via a polyethylene catheter intrarectally. High-performance liquid chromatography analyses showed that HBE contained 0.13% and 0.5% oleanolic acid and ursolic acid, respectively. Elevated myeloperoxidase activity and lipid peroxidation were attenuated in the HA group. The H and HM groups showed marked reductions in colitis-induced decreases in total thiol molecules and body weight. The histopathological studies revealed that HBE decreased colitis-induced edema and infiltration of neutrophils. Our data suggest the anti-inflammatory and antioxidant effects of HBE and atorvastatin protect against AA-induced colitis. The anti-inflammatory effect of HBE may be attributable to its ability to decrease myeloperoxidase activity as a biomarker of neutrophil infiltration.

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“…5) These negative effects are mainly caused by the formation of free radicals and mediated by free radical damage to lipids, proteins, and DNA. 6) Many reports have shown that natural products and their derivatives can protect against ROS-induced damage. Accordingly, they may have potential applications in preventing and/or curing diseases.…”

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confidence: 99%

Synergistic Antioxidant Activities of Eight Traditional Chinese Herb Pairs

Yang

et al. 2009

Biological & Pharmaceutical Bulletin

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Oxidative stress is mainly induced by reactive oxygen species (ROS) such as hydroxyl radicals ( · OH), hydrogen peroxide (H 2 O 2 ), and superoxide radical anions (O 2 Ϫ˙) . The adverse effects of oxidative stress have been demonstrated in several groups of diseases, including cardiovascular disease and heart disease, 1,2) liver injury, 3) acute and chronic renal damage, 4) and cancer. 5) These negative effects are mainly caused by the formation of free radicals and mediated by free radical damage to lipids, proteins, and DNA. 6) Many reports have shown that natural products and their derivatives can protect against ROS-induced damage. Accordingly, they may have potential applications in preventing and/or curing diseases. 7,8) In recent years, traditional Chinese herbs have been found to possess excellent antioxidant activities [9][10][11][12][13][14] ; the phenolic and flavonoid components, in particular, have been identified as excellent antioxidants that have proven to be effective in scavenging free radicals. [15][16][17] Therefore, the use of herbs to inhibit oxidative stress and decrease damage from free radicals has garnered much attention.More than 2000 herbs have been recorded in the Compendium of Materia Medica, one of the most famous ancient Chinese herb books, and most of these traditional Chinese herbs were applied in the form of multi-herb formulas in medical treatments and as dietary supplements. However, the application of herbal prescriptions today is mainly based on a doctor's experience and not on pharmacological mechanisms.18) Traditional Chinese herb pairs (TCHPs), which are the basic unit in traditional Chinese prescriptions and an intermediate point between single herbs and multi-herb recipes, 19) consist of two relatively standard single herbs. Many herb pairs were recorded in the Treatise on Febrile and Miscellaneous Diseases and in the Synopsis of the Golden Chamber. According to Chinese records and the classic books about herbs in China, many TCHPs showed significantly better pharmacological efficacy than when the herbs were used individually. [20][21][22][23] For instance, the complete Qizhu Tang formula (composed of four herbs) was more effective in preventing cerebral oxidative injury in rats than any of the incomplete formulas or single herbs. 24) A TCHP, Astragalus membranaceus and Paeonia lactiflora (AME-PL), inhibited liver fibrosis in rats treated with carbon tetrachloride, and exhibited an increased hepato-protective capability relative to either of the herbs used individually. 20) However, the mechanisms by which the formulae and TCHPs achieve this synergism have not been elucidated, and changes to the combinations have rarely been studied. In order to investigate the mechanism of this synergy, six herbs were tested, including Radix Astragali (Astragalus membranaceus (AME)), Radix Paeoniae Alba (Paeonia lactiflora (PL)), Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala (AMA)), Radix Angelicae Sinensis (Angelica sinensis (AS)), Radix Glycyrrhizae (Glycyrrhiza...

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Antioxidant Activity of Iranian Echium amoenum Fisch & C.A. Mey Flower Decoction in Humans: A cross‐sectional Before/After Clinical Trial

Cited by 67 publications

References 31 publications

Neuroprotective effects of Buyang Huanwu decoction against hydrogen peroxide induced oxidative injury in Schwann cells

Neuroprotective effects of Buyang Huanwu decoction against hydrogen peroxide induced oxidative injury in Schwann cells

Comparative Protective Effect of Hawthorn Berry Hydroalcoholic Extract, Atorvastatin, and Mesalamine on Experimentally Induced Colitis in Rats

Synergistic Antioxidant Activities of Eight Traditional Chinese Herb Pairs

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