Oxidative stress in preeclampsia and the role of free fetal hemoglobin

Hansson, Stefan R.; Nääv, Åsa; Erlandsson, Lena

doi:10.3389/fphys.2014.00516

Cited by 113 publications

(121 citation statements)

References 159 publications

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“…Oxidative stress from unbalanced free radical formation is produced within the trophoblast cell, the sources may vary from O, eNOS uncoupling, NADPH oxidase and mitochondria. Proxynitrite formation, lipid peroxidation, protein modiication, matrix metalloproteinase (MMP) activation and DNA damage contribute to endothelial dysfunction and are a result of the combination of these events [7,9]. In PE, superoxide generation by XO has been shown in placental reperfusion injury.…”

Section: +mentioning

confidence: 99%

“…In PE, superoxide generation by XO has been shown in placental reperfusion injury. Since PE is characterized by hyperuricemia, XO is presumably the source of uncontrolled ROS production when the concentration of its oxidase form is increased [7,9].…”

Section: +mentioning

confidence: 99%

“…The prolonged state of hypoxia causes an oxidative damage to the placental barrier which increases fetal hemoglobin gene expression and free fetal hemoglobin accumulation in placenta. The accumulation of fetal hemoglobin and its metabolites due to is toxicity results in damage through three pathways [4,7].…”

Section: Placental Dysfunctionmentioning

confidence: 99%

“…• 3rd pathway: the heme group of the hemoglobin molecule triggers an inlammatory response by activating neutrophils and cytokines production [4,7].…”

Section: +mentioning

confidence: 99%

“…In PE, the phenotype of placenta and intrauterine growth restriction are correlated with ER stress. In urine, misfolded proteins can be found, making it a viable biomarker for the Congo red test [7,8].…”

Section: +mentioning

confidence: 99%

See 4 more Smart Citations

Pharmacological Opportunities for Prevention of Preeclampsia

García-Benavides¹,

Molina²,

Vega³

et al. 2017

Obstetrics

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Preeclampsia (PE) is a disorder that occurs during pregnancy, it has an estimated worldwide prevalence of 5-8%, being one of the leading causes of maternal and perinatal morbidity and mortality. Currently, diferent diagnostic criteria exist, however, due to its complexity; the clinical presentation that makes up this syndrome could make its presence unclear. The pathophysiology of PE has been recently postulated and divided into three processes: inadequate uterine remodeling, placental dysfunction and maternal endothelial dysfunction. Despite the advances in the treatment of PE, the outcome of the medical interventions has failed to decrease the morbidity and mortality of this disease. The main reason might be the multifactorial origin of pathogenic processes that lead to the development of PE. That is why treatment is focused on the prevention of PE in patients that might present the risk before developing it late in pregnancy. The knowledge of the pathophysiological factors that trigger the processes that culminate in the presentation of PE, is key for prevention of this disease. However, the origin of these processes is poorly understood. It may be atributed to the ethical considerations that come with the study of these population of patients compared with the study of nonpregnant women.

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Section: +mentioning

confidence: 99%

Section: +mentioning

confidence: 99%

Section: Placental Dysfunctionmentioning

confidence: 99%

“…• 3rd pathway: the heme group of the hemoglobin molecule triggers an inlammatory response by activating neutrophils and cytokines production [4,7].…”

Section: +mentioning

confidence: 99%

Section: +mentioning

confidence: 99%

See 3 more Smart Citations

Pharmacological Opportunities for Prevention of Preeclampsia

García-Benavides¹,

Molina²,

Vega³

et al. 2017

Obstetrics

View full text Add to dashboard Cite

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Impact of IL‐22 and IL‐22 receptor alpha 1 polymorphisms on preeclampsia risk in Chinese Han women

Niu¹,

Zhao²,

Liu³

et al. 2018

J of Cellular Biochemistry

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Previous studies have indicated that an increased inflammatory response plays an important role in preeclampsia (PE), and rising levels of interleukin (IL)-22 can trigger inflammation and hyperproliferation, leading to increased production of several pro-inflammatory cytokines such as IL-1, IL-6, and IL-8. We aimed to investigate the association between polymorphisms of IL-22 and IL-22 receptor alpha 1 gene (IL-22RA1) and PE in Chinese Han population. Single nucleotide polymorphisms (SNPs) rs2227485 in IL-22 and rs3795299 in IL-22RA were genotyped by Taqman real-time PCR in 1071 PE patients and 1263 control subjects. Differences in genetic distribution were compared between two groups using the chi-square test. Significant differences were observed in genotypic and allelic frequencies of IL-22RA1 rs3795299 between healthy controls and PE patients (P < 0.001 by genotype; P = 0.001, odds ratio = 1.253, 95% confidence interval 1.103-1.424 by allele). There were also significant differences in genotypic and allelic frequencies of rs3795299 between late-onset/mild PE and control groups. In addition, we found obvious statistic difference for the allele of early-onset PE/the genotype of late-onset PE and control subgroups for IL-22 rs2227485. IL-22 rs2227485 and IL-22RA1 rs3795299 may be associated with the development of PE in Chinese Han population. However, further validation is required in other populations, as well as an evaluation of the association of other SNPs in IL-22 and IL-22RA1 with PE.

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Roles of microRNAs in preeclampsia

Lü

et al. 2018

Journal Cellular Physiology

128

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Preeclampsia (PE) is a complex disorder that is characterized by hypertension and proteinuria after the 20th week of pregnancy, and it causes most neonatal morbidity and perinatal mortality. Most studies suggest that placental dysfunction is the main cause of PE. However, genetic factors, immune factors, and systemic inflammation are also related to the pathophysiology of this syndrome. Thus far, the exact pathogenesis of PE is not yet fully understood, and intense research efforts are focused on PE to elucidate the pathophysiological mechanisms. MicroRNAs (miRNAs) refer to small single-stranded and noncoding molecules that can negatively regulate gene expression, and miRNA regulatory networks play an important role in diverse pathological processes. Many studies have confirmed deregulated miRNA in pregnant patients with PE, and the function and mechanism of these differentially expressed miRNA are gradually being revealed. In this review, we summarize the current research about miRNA involved in PE, including placenta-specific miRNA, their predictive value, and their function in the development of PE. This review will provide fundamental evidence of miRNA in PE, and further studies are necessary to explore the roles of miRNA in the early diagnosis and treatment of PE.

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Oxidative stress in preeclampsia and the role of free fetal hemoglobin

Cited by 113 publications

References 159 publications

Pharmacological Opportunities for Prevention of Preeclampsia

Pharmacological Opportunities for Prevention of Preeclampsia

Impact of IL‐22 and IL‐22 receptor alpha 1 polymorphisms on preeclampsia risk in Chinese Han women

Roles of microRNAs in preeclampsia

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