Impact of IL‐22 and IL‐22 receptor alpha 1 polymorphisms on preeclampsia risk in Chinese Han women

Niu, Zhaoyuan; Zhao, Xin; Liu, Hongling; Quan, Jing; Lin, Yan; Li, Jing; Wang, Jingli; Liu, Mengchun; Song, Weiqing; Chen, Aiping; Liu, Shiguo

doi:10.1002/jcb.26640

Cited by 5 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found significant difference for the genotype of IL-22 rs2227485 and GPX4 rs713041 associated with the mild, severe, and early-onset PE. Furthermore, the GPX4 rs713041 C allele has the higher risk for pathogenesis of PE [27,29]. Those that are just single genes without systematic haplotype analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Genotyping of 8 and 10 candidate SNPs related to inflammatory and oxidative stress, respectively, (Tables 1 and 2) was performed using predesigned TaqMan allelic discrimination real-time PCR followed by partial validation by Sanger sequencing. All women who were genotyped were retrospectively confirmed from our previous studies [23][24][25][26][27][28][29][30][31][32][33][34].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia

Chen

Zhao

Wang

et al. 2020

Journal of Immunology Research

Self Cite

View full text Add to dashboard Cite

Unbalanced inflammatory reactions and oxidative stress are inseparably interconnected, and both may play crucial roles in the pathophysiological mechanisms of preeclampsia (PE). In the published previous studies, we have genotyped for SNPs that related to inflammation (rs2227485, rs153109, rs17855750, rs2027432, rs2275913, rs763780, rs4819554, and rs13015714) and oxidative stress (rs1695, rs4680, rs1800566, rs4807542, rs713041, rs7579, rs230813, rs1004467, rs3824755, and rs9932581) to investigate whether these polymorphisms were associated with susceptibility to PE in a Chinese Han population. In this present study, we collected these data of experimental and clinical from above studies for haplotype analysis of inflammation-related SNPs in 631 PE patients and 720 normal pregnancy and oxidative stress-related SNPs in 342 PE patients and 457 normal pregnancies for susceptibility to PE. The data of genotype distribution and allele frequency comparisons after correction for multiple comparisons (P/8 or P/10) showed 2 among the 8 candidate inflammation-related SNPs have significant differences (rs2027432 genotype χ2=407.377,p<0.001,p<0.00625). Moreover, the minor alleles of rs2027432 T (minor allele χ2=450.923,p<0.001,p<0.00625;OR=21.439,95%CI=15.181‐30.278) and rs4819554 G (minor allele χ2=163.465,p<0.001,p<0.00625;OR=5.814,95%CI=4.380‐7.719) were confirmed as risk allele of PE, respectively. Our analysis revealed rs2027432 (TT) of NLRP3 and rs4819554 (GG) of IL-17RA are risk factors for PE. However, no significant difference was found at the oxidative stress-related SNPs. In the candidate loci for oxidative stress, we also identified 3 SNP matches (rs4807542 and rs713041, rs230813 and rs75799, rs1004467 and rs3824755) that had high linkage disequilibrium (LD) with each other and were selected as a block (r2=0.98,r2=0.97,r2=0.97,r2>0.9), and the GT and GC haplotypes of rs4807542 and rs713041 in GPX4 showed significant differences between the PE and control groups (χ2=5.143,p=0.0233,p<0.05;χ2=6.373,p=0.0116,p<0.05). So, we inferred that polymorphisms of NLRP3 rs2027432 and IL-17RA rs4819554, which are related to inflammation, and the rs713041 variant of GPX4, which is related to oxidative stress, were associated with susceptibility to PE. The GT and GC haplotypes of rs4807542 and rs713041 in GPX4 may increase the risk of PE in the Chinese Han population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia

Chen

Zhao

Wang

et al. 2020

Journal of Immunology Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Then rs2227485 was assessed under the dominant model of the C allele (CC/CT + TT genotype) or the recessive model of the T allele (TT/CC + CT genotype), and observed a significant difference under the recessive model of the T allele ( P < .001, OR = 0.620, 95% CI 0.495–0.776). [ 81 ]…”

Section: Methodsmentioning

confidence: 99%

Cytokine-polymorphisms associated with Preeclampsia: A review

et al. 2022

View full text Add to dashboard Cite

Background: Preeclampsia (PE) is a syndromic disorder that affects 2% to 8% of pregnancies and is diagnosed principally when hypertension appears in the second-d half of pregnancy. WHO estimates the incidence of PE to be seven times higher in developing countries than in developed countries. Severe preeclampsia/eclampsia is one of the most important causes of maternal mortality, associated with 50,000 to 100,000 annual deaths globally as well as serious fetal and neonatal morbidity and mortality, especially in developing countries. Even though evidence from family-based studies suggest PE has a heritable component, its etiology, and specific genetic contributions remain unclear. Many studies examining the genetic factors contributing to PE have been conducted, most of them are focused on single nucleotide polymorphisms (SNPs). Given that PE has a very important inflammatory component, is mandatory to examine cytokine-SNPs for elucidating all mechanisms involved in this pathology. In this review, we describe the most important cytokine-polymorphisms associated with the onset and development of PE. We aim to provide current and relevant evidence in this regard. Methods: We searched English databases such as PubMed and the National Center for Biotechnology Information. The publication time of the papers was set from the establishment of the databases to February 2022. All studies about Th1/Th2/Th17 cytokines polymorphisms were included in our study. Results: SNPs in IFN-γ, TNF-α, IL-4, IL-6, IL-10, IL-17A, and IL-22 are associated with the development, early-onset and severity of PE, being the Th1/Th2/Th17 responses affected by the presence of these SNPs. Conclusions: The changes in Th1/Th2/Th17 response modify processes such as placentation, control of inflammation, and vascular function. Nonetheless, association studies have shown different results depending on sample size, diagnostic, and population.

show abstract

Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia

Mazlum

Gharesi‐Fard

Hadinedoushan

et al. 2021

Hypertension in Pregnancy

View full text Add to dashboard Cite

Impact of IL‐22 and IL‐22 receptor alpha 1 polymorphisms on preeclampsia risk in Chinese Han women

Cited by 5 publications

References 28 publications

Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia

Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia

Cytokine-polymorphisms associated with Preeclampsia: A review

Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia

Contact Info

Product

Resources

About