Oxidative stress in Portuguese children with Down syndrome

Pinto, Mónica; Neves, J.V.; Palha, Miguel; Bicho, Manuel

doi:10.3104/reports.134

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…These alterations favor an increase in the oxidative stress commonly found in these subjects. In this context, some studies have demonstrated an increase of nearly 50% in the activity of Cu/Zn superoxide dismutase (SOD) in plasma and erythrocytes of DS patients [5,6]. For some researchers, the alterations demonstrated in the activity of SOD in DS patients are probably due to an increase in the expression of the gene for this enzyme in cells of patients with the presence of an additional chromosome 21 [7].…”

Section: Introductionmentioning

confidence: 99%

Zinc Nutritional Status in Adolescents with Down Syndrome

Marques

Sousa

Monte

et al. 2007

Biol Trace Elem Res

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Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents with Down syndrome was evaluated by means of biochemical parameters and diet. A case-control study was performed in a group of adolescents with Down syndrome (n=30) and a control group (n=32), of both sexes, aged 10 to 19 years. Diet evaluation was accomplished by using a 3-day dietary record, and the analysis was performed by the NutWin program, version 1.5. Antropometric measurements were performed for evaluation of body composition. The Znrelated nutritional status of the groups was evaluated by means of zinc concentration determinations in plasma and erythrocytes, and 24-h urinary zinc excretion, by using the Biol Trace Elem Res (method of atomic absorption spectroscopy. The diet of both groups presented adequate concentrations of lipids, proteins, carbohydrates, and zinc. The mean values found for zinc concentration in erythrocytes were 49.2±8.5 μg Zn/g Hb for the Down syndrome group and 35.9±6.1 μg Zn/g Hb for the control group (p=0.001). The average values found for zinc concentration in plasma were 67.6±25.6 μg/dL for the Down syndrome group and 68.9± 22.3 μg/dL for the control group. The mean values found for zinc concentration in urine were 244.3±194.9 μg Zn/24 h for the Down syndrome group and 200.3±236.4 μg Zn/24 h for the control group. Assessment of body composition revealed overweight (26.7%) and obesity (6.6%) in the Down syndrome group. In this study, patients with Down syndrome presented altered zinc levels for some cellular compartments, and the average zinc concentrations were low in plasma and urine and elevated in erythrocytes.

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Section: Introductionmentioning

confidence: 99%

Zinc Nutritional Status in Adolescents with Down Syndrome

Marques

Sousa

Monte

et al. 2007

Biol Trace Elem Res

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“…Results from a mice model suggest an increase in basal generation of ROS in neurons, probably caused by deficiency in mitochondrial ET. Oxidative imbalance in DS individuals may contribute to accelerated aging [59, 60]. Oxidative damage to protein confirms the role of OS in DS [61].…”

Section: Down’s Syndrome (Ds)mentioning

confidence: 96%

Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species

Kovacic

Somanathan²

2012

Current Neuropharmacology

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Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson’s, Huntington’s, Alzheimer’s, prions, Down’s syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.

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“…Excess of chromosomes leads to overexpression of the SOD1 gene, and to elevated H 2 O 2 levels that cannot be completely eliminated by CAT and GPx, so overproduction of ROS occurs (Figure 2) [22][23][24][25]. SOD1 was found to be 50% higher than normal in various cells and tissues of people with DS, so the SOD1/GPx activity ratio was consequently altered [19,22,[26][27][28][29].…”

Section: Ds Issues Targeted By Nutritional Supplementation 41 Oxidati...mentioning

confidence: 99%

Supplements and Down Syndrome

Ravančić¹,

Obradović²

2023

Dietary Supplements - Challenges and Future Research

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Down syndrome (DS) is one of the most common genetic disorders associated with a number of difficulties that are visible through the motor and cognitive development. Some theories claim that intake of supplements in very high doses could upgrade the physical and intellectual status of individuals with DS. Numerous papers have been published to support these theories, but at the same time, a great number of papers have warned of the risks of uncontrolled, excessive use of dietary supplements and asked for the proof of such claims by independent scientific studies. In this chapter, we will provide a review of the most commonly used supplements and major findings on this matter. Open access to information about the positive and negative sides of such supplementation is primarily important for guardians of people with DS in order to make the decision whether to use such preparations. It could also be an incentive for scientists to focus on the development of beneficial and safe therapies.

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Oxidative stress in Portuguese children with Down syndrome

Cited by 6 publications

References 20 publications

Zinc Nutritional Status in Adolescents with Down Syndrome

Zinc Nutritional Status in Adolescents with Down Syndrome

Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species

Supplements and Down Syndrome

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