Zinc Nutritional Status in Adolescents with Down Syndrome

Marques, Raynério Costa; Sousa, Artemí­zia Francisca de; Monte, Semíramis Jamil Hadad do; Oliveira, Francisco Erasmo de; Nogueira, Nadir do Nascimento; Marreiro, Dilina do Nascimento

doi:10.1007/s12011-007-0061-5

Cited by 16 publications

(13 citation statements)

References 25 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mean values of 12.8 and 8.4 μg/mL were found for erythrocyte Zn in groups D and C, respectively. Purice et al [28] and Marques et al [29] also observed higher erythrocyte Zn concentration in children and in adolescents with DS when compared with those in the control group.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Nutritional Status of Zinc in Children with Down Syndrome

Lima

Cardoso

Cozzolino

2009

Biol Trace Elem Res

View full text Add to dashboard Cite

Experimental and clinical studies have established that zinc metabolism is altered in individuals with Down syndrome (DS). The present study intends to evaluate the nutritional status of zinc in children with DS by determining their biochemical and dietary parameters. The investigation was carried out on a group of children with DS (n = 35) and compared with a control group (n = 33), both aging between 4 and 11 years. Weight-for-age, height-for-age, and weight-for-height indexes and diet were evaluated by using a 3-day dietary record. Zinc was evaluated in plasma, erythrocytes, and 24-h urine collection by using the method of atomic absorption spectroscopy. The frequency of short stature was higher in children with DS. Both groups presented high protein content, adequate concentrations of lipids and carbohydrates, and deficit in calories. Adequate zinc intake was observed in 40% of children with DS and in 67% of the control group. Zinc concentrations were significantly lower in plasma and urine and higher in erythrocytes of children with DS. The results allowed us to conclude that the altered zinc nutritional status of individuals with Down syndrome contributes to clinical disturbances that usually appear with aging in these patients.

show abstract

Section: Discussionmentioning

confidence: 90%

“…Data showing a fall in zinc concentration in plasma may reflect a redistribution of the mineral by the organism, not necessarily an inhibition of its absorption [29]. Increased Zn concentration in erythrocytes and decrease in plasma may occur due to the presence of carbonic anhydrase, since Zn participates in its structure [30].…”

Section: Discussionmentioning

confidence: 99%

Nutritional Status of Zinc in Children with Down Syndrome

Lima

Cardoso

Cozzolino

2009

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…In the study performed by Soto-Quintana et al [23] and Marques et al [24], zinc concentration in plasma was evaluated in children with DS, and hypozincemia was identified with a significant difference regarding the control group. Yenigun et al [25] also observed low zinc levels in plasma of DS patients.…”

Section: Resultsmentioning

confidence: 99%

Effect of Zinc Supplementation on Thyroid Hormone Metabolism of Adolescents with Down Syndrome

Marreiro

Sousa

Nogueira

et al. 2008

Biol Trace Elem Res

Self Cite

View full text Add to dashboard Cite

Studies have evidenced that zinc metabolism is altered in the presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the effect of zinc supplementation on thyroid hormone metabolism was evaluated in adolescents with Down syndrome. A prospective study was carried out on 16 adolescents with Down syndrome (age: 10-19 years) who were randomized for treatment with 30 mg zinc daily for 4 weeks. Diet evaluation was accomplished y using a 3-day dietary record, and the analysis was performed by the NutWin program, version 1.5. Anthropometric measurements were performed for evaluation of body composition. The Zn-related nutritional status of the groups was evaluated by means of zinc concentration determinations in plasma and erythrocytes using the method of atomic absorption spectroscopy, and the thyroid hormone was obtained by radioimmunoassay. The diet of patients with Down syndrome, before and after the intervention presented reduced energy level and adequate zinc concentrations. Mean plasma zinc values were 59.2 +/- 13.2 and 71.0 +/- 21.9 microg/dL before and after the intervention, respectively. Erythrocyte concentrations of the mineral before supplementation, instead, were 51.5 microg/dL +/- 11.1 microg Zn/gHb, and at the end of the experiment, they were 42.9 +/- 8/5 microg Zn/gHb, with a significant statistical difference (p < 0.05). Serum concentrations of T(4) hormone before and after zinc supplementation were 1.26 +/- 0.20 and 1.54 +/- 0.63 pg/mL, respectively. Mean T(3) values before intervention were 2.47 +/- 037 pg/mL and, after supplementation, 2.25 +/- 0.67 pg/mL, without significant statistical difference (p > 0.05). Intervention with zinc showed to be effective in the stabilization of the concentrations of this mineral in plasma and erythrocytes, but had no influence on the metabolism of thyroid hormones.

show abstract

“…Studies have evidenced that Zn metabolism is altered in children with Down syndrome and Zn levels appear to be related to the metabolic alterations typical of this syndrome. In particular, adolescent patients with Down syndrome presented altered Zn levels for some cellular compartments and the average Zn concentrations were low in plasma and urine and elevated in erythrocytes [24]. Also, learning impairment, dyslexia, and autism may be associated to variations in trace elements concentration [25][26][27][28].…”

Section: Reference Values In Specific Groups Of Population: the Childmentioning

confidence: 99%