Oxidative Stress in Polycystic Ovary Syndrome

Papalou, Olga; Víctor, Víctor M.; Diamanti-Kandarakis, Evanthia

doi:10.2174/1381612822666160216151852

Cited by 104 publications

(72 citation statements)

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“…Acne, hirsutism, seborrhoea, menstrual irregularities, anovulation, infertility, obesity, and several metabolic (e.g., glucose and lipid abnormalities) and atherosclerotic disorders are among the symptoms and signs of this disease [45]. With regard to the aetiology of PCOS, some causative factors such as hormonal disorders, adipose tissue dysfunction, and oxidative stress have been blamed, but a definitive consensus has not been reached [6]. However, in recent years, insulin resistance (IR) has been reported to play an important role in the progression of PCOS [178].…”

Section: Introductionmentioning

confidence: 99%

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Sak

Uyanıkoğlu

Incebiyik

et al. 2018

Clin Exp Reprod Med

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ObjectiveThe aim of this study was to compare serum fetuin-A levels and oxidative stress markers, as indicators of insulin resistance, in women with polycystic ovary syndrome (PCOS) and in healthy controls.MethodsThis prospective case-control study included 46 patients with PCOS and 48 age- and body mass index–matched control women. Levels of serum hormones, fetuin-A, and oxidative stress markers were measured in blood samples taken during the early follicular period from each participant.ResultsFollicle-stimulating hormone (FSH), luteinising hormone (LH), total testosterone levels, and the LH/FSH ratio were found to be significantly higher in women with PCOS than in controls. Serum total antioxidant status, total oxidant status, and oxidative stress index parameters all indicated significantly higher levels of oxidative stress in PCOS patients than in controls. Serum fetuin-A levels, which were analyzed as an indicator of insulin resistance, were higher in the PCOS group than in the control group (210.26±65.06 µg/mL and 182.68±51.20 µg/mL, respectively; p=0.024).ConclusionThe data obtained from the present study suggest that higher levels of both serum fetuin-A and oxidative stress markers might be related with PCOS.

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Section: Introductionmentioning

confidence: 99%

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Sak

Uyanıkoğlu

Incebiyik

et al. 2018

Clin Exp Reprod Med

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“…It is not only one of the most frequent causes of secondary amenorrhea and infertility due to the chronic anovulation and hyperandrogenism, because it still has a set of associated metabolic disorders characterized by insulin resistance (IR) [2], impaired glucose tolerance (IGT) [3], dyslipidemia [4] and low-grade chronic 2016 Vol. 7 No.…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 80% of women with PCOS present IR [6], compared with only 10% to 25% of individuals in the general population [7], associated with hyperinsulinemia and it may occur regardless of body mass index (BMI) and degree of adiposity [8]. Some studies support the hypothesis that IR influences in the pathogenesis of PCOS, acting as integration agent between metabolic and androgenic abnormalities [2,3,5].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Oxidative Stress in Inflammatory Process and Insulin Resistance in Obese Women with Polycystic Ovary Syndrome

Santos¹,

Azevedo²,

Lemos³

2016

Transl Biomed

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“…Its etiopathophysiological core remains vague; however, gonadotropin-secretory alterations, androgen excess, insulin resistance and low-grade inflammation, in conjunction with the pivotal contribution of genetic and environmental parameters, are all involved in the interplay net of the syndrome (176,177). Recently, oxidative stress has also been highlighted as another potent modulator of PCOS (178,179).…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women

Diamanti-Kandarakis

Papalou²,

Kandaraki

et al. 2017

European Journal of Endocrinology

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Nutrition can generate oxidative stress and trigger a cascade of molecular events that can disrupt oxidative and hormonal balance. Nutrient ingestion promotes a major inflammatory and oxidative response at the cellular level in the postprandial state, altering the metabolic state of tissues. A domino of unfavorable metabolic changes is orchestrated in the main metabolic organs, including adipose tissue, skeletal muscle, liver and pancreas, where subclinical inflammation, endothelial dysfunction, mitochondrial deregulation and impaired insulin response and secretion take place. Simultaneously, in reproductive tissues, nutrition-induced oxidative stress can potentially violate delicate oxidative balance that is mandatory to secure normal reproductive function. Taken all the above into account, nutrition and its accompanying postprandial oxidative stress, in the unique context of female hormonal background, can potentially compromise normal metabolic and reproductive functions in women and may act as an active mediator of various metabolic and reproductive disorders.

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Oxidative Stress in Polycystic Ovary Syndrome

Abstract: Oxidative stress, in conjunction with the rest etiologic mechanisms of PCOS and the cardinal contribution of environmental factors, leads to an adverse redox status that stigmatizes the natural process of the syndrome.

Cited by 104 publications

References 0 publications

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

The Influence of Oxidative Stress in Inflammatory Process and Insulin Resistance in Obese Women with Polycystic Ovary Syndrome

MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women

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