MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women

Diamanti-Kandarakis, Evanthia; Papalou, Olga; Kandaraki, Eleni; Kassi, Georgia

doi:10.1530/eje-16-0616

Cited by 44 publications

(32 citation statements)

References 211 publications

(193 reference statements)

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“…Nutrition can also cause oxidative stress, augment a cascade of molecular reactions in cells, and alter the metabolic state of tissues [ 5 ]. Oxidative metabolism and redox homeostasis are suggested to be an essential part of aerobic life [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

Saha

Lee

Won

et al. 2017

IJMS

325

205

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Inadequate or excessive nutrient consumption leads to oxidative stress, which may disrupt oxidative homeostasis, activate a cascade of molecular pathways, and alter the metabolic status of various tissues. Several foods and consumption patterns have been associated with various cancers and approximately 30–35% of the cancer cases are correlated with overnutrition or malnutrition. However, several contradictory studies are available regarding the association between diet and cancer risk, which remains to be elucidated. Concurrently, oxidative stress is a crucial factor for cancer progression and therapy. Nutritional oxidative stress may be induced by an imbalance between antioxidant defense and pro-oxidant load due to inadequate or excess nutrient supply. Oxidative stress is a physiological state where high levels of reactive oxygen species (ROS) and free radicals are generated. Several signaling pathways associated with carcinogenesis can additionally control ROS generation and regulate ROS downstream mechanisms, which could have potential implications in anticancer research. Cancer initiation may be modulated by the nutrition-mediated elevation in ROS levels, which can stimulate cancer initiation by triggering DNA mutations, damage, and pro-oncogenic signaling. Therefore, in this review, we have provided an overview of the relationship between nutrition, oxidative stress, and cancer initiation, and evaluated the impact of nutrient-mediated regulation of antioxidant capability against cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

Saha

Lee

Won

et al. 2017

IJMS

325

205

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“…Diet intake promotes a major oxidative response at the cellular level, and further alters the metabolic status of an organ including muscles 14 . Many previous studies have focused the induction of high-fat diets to metabolic dysfunction by oxidative stress in skeletal muscles 15 – 17 .…”

Section: Introductionmentioning

confidence: 99%

Oxidative and anti-oxidative status in muscle of young rats in response to six protein diets

Zhu¹,

Xiao²,

Hao

et al. 2017

Sci Rep

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We investigated the impact of six protein diets on oxidation and anti-oxidation status in the muscle of young rats. Rats were fed six protein diets for 14 days, including casein (control), and proteins isolated from soy, fish, chicken, pork and beef. Grx1, Trx1 and other oxidative metabolic indices in muscle were quantified. Compared with the casein diet, the soy protein diet had a similar oxidation level, but higher GSH and lower SOD activities. The chicken and fish protein groups had lower GSH and higher SOD activities, the pork protein group showed lower Grx1 levels than the casein group and the beef protein group showed the highest GSH, Grx1 and Trx1 levels as reflected by RT-PCR, Western blotting and immunohistochemistry analyses. Intake of meat proteins showed higher ROS and T-AOC but lower MDA levels than non-meat proteins, which may be due to the increase in Grx1 and Trx1 expression and other antioxidants. Meat proteins are more conducive to muscle of growing rats.

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“… 24 Thus, when women with PCOS have high body weight, they are affected by both intrinsic and extrinsic insulin resistance. 3 PCOS has recently been conceptualized as a condition of severe metabolic stress, 25 a position that we support as it provides a way to account for the pervasive molecular and biochemical derangements that occur in PCOS and variation in symptom profiles.…”

Section: Introductionmentioning

confidence: 77%

“…Obesity is common in women with PCOS and exacerbates the metabolic stress that we and others view as central to pathogenesis of the syndrome. 25 In a meta-analysis of mainly clinic-based samples (n = 35 studies), 69 49% of women with PCOS were classified as obese (95% CI 42–55%) and 54% had central adiposity (95% CI 43–62%). The proportions were around twofold higher than among comparison groups (obesity: relative risk [RR] = 2.8, 95% CI 1.9–4.1; central adiposity: RR = 1.7, 95% CI 1.3–2.3).…”

Section: How Pathophysiology Of Pcos Is Linked To Sleep Disturbancesmentioning

confidence: 99%

Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies

Fernandez

Moore

Ryswyk

et al. 2018

NSS

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Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting the reproductive, metabolic and psychological health of women. Clinic-based studies indicate that sleep disturbances and disorders including obstructive sleep apnea and excessive daytime sleepiness occur more frequently among women with PCOS compared to comparison groups without the syndrome. Evidence from the few available population-based studies is supportive. Women with PCOS tend to be overweight/obese, but this only partly accounts for their sleep problems as associations are generally upheld after adjustment for body mass index; sleep problems also occur in women with PCOS of normal weight. There are several, possibly bidirectional, pathways through which PCOS is associated with sleep disturbances. The pathophysiology of PCOS involves hyperandrogenemia, a form of insulin resistance unique to affected women, and possible changes in cortisol and melatonin secretion, arguably reflecting altered hypothalamic–pituitary–adrenal function. Psychological and behavioral pathways are also likely to play a role, as anxiety and depression, smoking, alcohol use and lack of physical activity are also common among women with PCOS, partly in response to the distressing symptoms they experience. The specific impact of sleep disturbances on the health of women with PCOS is not yet clear; however, both PCOS and sleep disturbances are associated with deterioration in cardiometabolic health in the longer term and increased risk of type 2 diabetes. Both immediate quality of life and longer-term health of women with PCOS are likely to benefit from diagnosis and management of sleep disorders as part of interdisciplinary health care.

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MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women

Cited by 44 publications

References 211 publications

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

Oxidative and anti-oxidative status in muscle of young rats in response to six protein diets

Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies

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