Oxidative stress in Perna perna and other bivalves as indicators of environmental stress in the Brazilian marine environment: Antioxidants, lipid peroxidation and DNA damage

Almeida, Eduardo Alves de; Bainy, Afonso Celso Dias; Loureiro, Ana Paula de Melo; Martinez, Gláucia Regina; Miyamoto, Sayuri; Onuki, Janice; Barbosa, Lívea Fujita; García, Camila; Prado, Fernanda Manso; Ronsein, Graziella Eliza; Sigolo, Carlos Alexandre Oliveira; Brochini, Cláudia Barbosa; Martins, Ana Maria Gracioso; Medeiros, Marisa H. G.; Mascio, Paolo Di

doi:10.1016/j.cbpa.2006.02.040

Cited by 227 publications

(57 citation statements)

References 95 publications

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“…as a consequences of change in seasons may therefore influence normal metabolic activities of organisms and the induction of oxidation stress as a consequence of increased generation of Reactive Oxygen Species (ROS) (Van der Oost et al, 2003;Ognjanovic et al, 2008;Malanga et al, 2009). The ROS can be highly toxic to aquatic organisms including molluscs after resulting in oxidation of lipid in membranes, protein and nucleic acids, polysaccharides and inhibition of vital enzymes (Mates, 2000;De Almeida et al, 2007;Tripathi et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Anti-reproductive Activity of Chlorophyllin on Fresh Water Snail Lymnaea acuminata

Singh¹,

Sing²

2015

Research J. of Parasitology

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The effects of Sub-lethal treatments (20 and 60% of 24 h LC 50 ) of chlorophyllin on the reproduction and development of Lymnaea acuminata has been studied. There was a significant decrease in the fecundity, hatchability and survival of the young snails. Treatment with 60% of 24 h LC 50 of chlorophyllin caused minimum fecundity (57 eggs/20 snails, 48 h) in summer (sunlight). After 48 h no egg laying and hatching was noted in snails exposed to 60% of 24 h LC 50 of chlorophyllin in both winter (sunlight) as well as in summer (sunlight). Development could not proceed beyond the veliger stage due to the death of the embryo. The developmental arrest was noticed in many egg strings leading to the high rate of mortality and there by reduction in hatchability of the eggs. Growth rate of survived snails was also very slow. This present study clearly shows that the efficacy of chlorophyllin gives significant control of reproduction of the snails even at sub-lethal exposure. The use of the natural products would have an added advantage against aquatic snails as it would be non toxic to the non target animals and less hazardous to the environment.

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Section: Discussionmentioning

confidence: 99%

Anti-reproductive Activity of Chlorophyllin on Fresh Water Snail Lymnaea acuminata

Singh¹,

Sing²

2015

Research J. of Parasitology

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“…De Oliveira et al (2005) demostraron incrementos en los productos de lipoperoxidación durante la anoxia en el cangrejo del Atlántico Chasmagnathus granulata después de 8 h de anoxia, no así se encontró variaciones en las defensas antioxidantes. De Almeida et al (2007) encontraron en el mejillón marrón P. perna daños oxidativos en el ADN y lipoperoxidación después de 24 h de exposición a anhidrobiosis. Sánchez (2013) encontró incrementos significativos en los niveles de TBARS en P. viridis bajo condiciones de anhidrobiosis y anoxia, tales valores pueden ser aumentados con la exposición a metales pesados como Cu y Cd.…”

Section: Discussionunclassified

Tolerancia a la anoxia y defensas antioxidantes en el mejillon verde Perna viridis (Linneus, 1758) bajo exposicion aguda al cadmio

Zapata-Vívenes

Tovar-Sánchez

Nusetti

et al. 2014

lajar

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Tolerancia a la anoxia y defensas antioxidantes en el mejillón verdeRESUMEN. Se estimó la sobrevivencia a la anoxia del mejillón verde Perna viridis después de siete días de exposición a 50 g L -1 de cadmio (Cd), seguido de un período de recuperación en el mar durante 21 días. En la glándula digestiva de los organismos experimentales se determinó los niveles de Cd acumulados, y marcadores de estrés oxidativo tales como: metalotioneínas (MT), glutatión reducido (GSH), peroxidación lipídica (TBARS) y las actividades de las enzimas catalasa (CAT), glutatión reductasa (GR) y glutatión-S-transferasa (GST). Los organismos expuestos a Cd mostraron una menor tolerancia al tratamiento anóxico, sin embargo una vez recuperados en el mar presentaron valores de sobrevivencia relativamente mayores en comparación a sus controles. Los organismos expuestos a Cd revelaron un incremento en la concentración de MT y la actividad de CAT, correlacionado al ingreso corporal de Cd. Los organismos transplantados al mar mostraron una disminución del metal acumulado, manteniendo niveles de MT incrementados. Los mejillones tratados y controles no exhibieron diferencias significativas en los marcadores de estrés oxidativo determinados (TBARS, GSH, GR y GST). El Cd acumulado posiblemente afectó algunas estrategias bioquímicas relacionadas con la tolerancia a la anoxia de P. viridis. Sin embargo, los altos niveles de MT en organismos pre-expuestos y posteriormente recuperados, podría condicionar la protección contra la toxicidad del Cd e indirectamente una mayor tolerancia a la anoxia. Palabras clave: Perna viridis, anoxia, cadmio, enzimas antioxidantes, glutatión reducido, lipoperoxidación, metalotioneínas. Anoxia tolerance and antioxidant defences in the green-lipped musselPerna viridis (Linnaeus, 1758) under acute cadmium exposure ABSTRACT. The survival to anoxia was measured from green-lipped mussel Perna viridis after of exposure to 50 µg L -1 cadmium (Cd) during seven days, followed by a recuperation period in the sea during 21 days. The levels of Cd, and oxidative stress biomarkers as metallothioneins (MT), reduced glutathione (GSH) and lipid peroxidation (TBARS), and maximal activities of catalase (CAT), glutathione reductase (GR) and glutathione-S-transferase (GST) were calculated in the digestive gland in experimental organisms. The Cd-exposed organisms showed an anoxia tolerance reduced; however, those organisms recovered in the sea showed a survival time to anoxia major in contrast to control organisms. The Cd-exposed organisms revealed a significant increase of MT and CAT correlated with Cd uptake. The Cd-preexposure and sea-transplanted mussels showed a significant reduction of metal accumulated, whereas the levels of MT was maintain heightened. Both, Cddepurated and non-depurated organisms did not exhibit significant differences among the biomarkers of oxidative stress: TBARS, GSH and enzymes tested. The uptake Cd possibly affected some biochemical mechanisms related to anoxia tolerance, however the high levels of MT in the pre...

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“…The TBARS content was measured in animals treated with 600 g Fe/l, and a significant increase was observed among control and treated mussels. Lately, Alves de Almeida et al [25] exposed mussels from Perna perna species to 500 g/l Fe (as FeSO4) and it was reported that mussels exposed to Fe for 12, 24 and 72 h presented increased phospholipid hydroperoxide glutathione peroxidase (PHGPx) activity, and no differences in MDA levels. However, at 120 h of Fe exposure both, MDA and PHGPx were significantly higher than control.…”

Section: Fe Overload In Aquatic Organismsmentioning

confidence: 99%

“…H2O2 induced oxidative stress may have triggered the endogenous antioxidant system in such a manner that by day 7 of exposure to Fe excess the TBARS content was reduced to the starting values. Even though the superoxide dismutase (SOD) activity was not changed, induction of other protective mechanisms, such as metallothioneins, might act as effective transient control of heavy metal effects during the initial phase of exposure [24,25]. Other studies evaluate the impact of nutritional Fe on Fe level and concentrations of MDA in tissues.…”

Section: Fe Overload In Aquatic Organismsmentioning

confidence: 99%

Iron Overload and Lipid Peroxidation in Biological Systems

González¹,

Piloni²,

Puntarulo³

2012

Lipid Peroxidation

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Oxidative stress in Perna perna and other bivalves as indicators of environmental stress in the Brazilian marine environment: Antioxidants, lipid peroxidation and DNA damage

Cited by 227 publications

References 95 publications

Anti-reproductive Activity of Chlorophyllin on Fresh Water Snail Lymnaea acuminata

Anti-reproductive Activity of Chlorophyllin on Fresh Water Snail Lymnaea acuminata

Tolerancia a la anoxia y defensas antioxidantes en el mejillon verde Perna viridis (Linneus, 1758) bajo exposicion aguda al cadmio

Iron Overload and Lipid Peroxidation in Biological Systems

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