Oxidative stress in patients with unstable angina

Abstract

The aim of this study was to determine whether oxidative stress occurs in unstable angina. Thirty patients with unstable angina class B (Braunwald classification) were prospectively studied. Control groups consisted of 23 patients presenting with stable angina and of 21 age-matched healthy volunteers. Upon admission and every 8 h for 24 h, blood samples were drawn for the determination of plasma malondialdehyde (MDA) levels, Se-glutathione peroxidase (GPX) activity, erythrocyte reduced glutathione (GSH) concentrations, erythrocyte GPX and superoxide dismutase (SOD) activities. Coronary angiograms were performed within 4 days of admission in 26 out of the 30 patients included in the study. Nine of these 30 patients were subsequently identified as presenting a non-Q wave myocardial infarction and were separately examined. On admission, only plasma MDA levels and erythrocyte GSH concentrations differed among groups. Plasma MDA levels of patients presenting with unstable angina (P < 0.01) and acute myocardial infarction (P < 0.05) were higher than those of patients with stable angina and of normal volunteers, whereas there was no difference in these parameters between unstable angina and non-Q wave myocardial infarction groups. Erythrocyte GSH concentration was lower in all patient groups as compared to normal subjects. ANOVA for repeated measures showed no difference between admission and subsequent levels for all parameters. Finally, no difference was observed for any of the parameters when anti-ischaemic or anti-aggregant treatment before admission, or the number of affected vessels on coronary angiograms, were considered. We conclude that an oxidative stress can be evidenced in patients with unstable angina or acute myocardial infarction.

Oxidative Stress, Endogenous Antioxidant and Ischemia-modified Albumin in Normolipidemic Acute Myocardial Infarction Patients

“…29) The current study observed a significant reduction in albumin, uric acid and total bilirubin and a significant increase in MDA, conjugated dienes and IscMA in AMI patients. The findings of the present study are similar to those of the study conducted by Dubois Rande et al 30) and Mc Murray 31) which reported a significant rise in MDA level and lipid peroxidation, with a concomitant decrease in antioxidants in patients with unstable angina and chronic heart failure. The present study also concurs with studies of Verma et al,32) who demonstrated that there was a significant drop in antioxidant, whereas lipid peroxides were significantly higher in AMI patients, compared with controls.…”

Antioxidant status in patients with acute myocardial infarction

“…This is similar to work of Dubois Rande et al (17) and Mc Murray (18) who showed a decrease in antioxidant enzyme activities and increase in lipid peroxidation products (MDA, TBARS) in patients with unstable angina and chronic heart failure.…”

The Status of Glutathione Peroxidase, Superoxide Dismutase, Vitamins A, C, E and Malondialdehyde in Patients with Cardiovascular Disease in Zahedan, Southeast Iran

“…McMurray et al (29) and Dubois-Randé et al (49) similarly showed a decrease in antioxidant enzyme activities and increase in reaction oxygen products in patients with chronic heart failure and unstable angina, respectively. Although the antioxidant system (enzymatic/non-enzymatic) detoxifies ROS generated (17,30), an imbalance between the factors and tendency of lipid profiles to increase in CVD patients can be enhanced by oxidative stress.…”