Oxidative stress in non‐small cell lung cancer patients after chemotherapy: Association with treatment response

Gupta, Abhaya; Srivastava, Shruti; Prasad, Rajendra; Natu, S.M.; Mittal, Balraj; Negi, Mahendra Pal Singh; Srivastava, Anand

doi:10.1111/j.1440-1843.2009.01703.x

Cited by 67 publications

(67 citation statements)

References 49 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In line with this, it has also been well established that patients with underlying respiratory conditions such as chronic obstructive pulmonary disease (COPD), which also represents a major cause of morbidity and mortality in developed countries, exhibit a significantly greater risk of LC (3,(10)(11)(12)(13)(14)(15)(16)(17). Importantly, in patients with moderate-to-severe COPD, the prevalence of LC can go up as high as five-fold that of smokers without the disease (18)(19)(20)(21)(22)(23)(24). Furthermore, the epidemiologic relevance of emphysema in the development of LC in patients with COPD has also been highlighted (2)(3)(4)(5)16).…”

Section: Introductionmentioning

confidence: 62%

“…More recently, patients with advanced LC exhibited increased systemic oxidative stress levels compared to healthy controls (18,33). In a previous study from our group (25), protein carbonylation levels, as measured by malondialdehyde (MDA)-protein adducts, were also increased in the normal epithelium of patients with LC, especially in patients with underlying COPD, whose levels were significantly greater than in those without this disease.…”

Section: Redox Balancementioning

confidence: 88%

“…Oxidative and nitrosative stress were shown to favor carcinogenesis through the activation of cellular processes that result in neoplastic transformation, the induction of DNA mutations (32,114), or even through induction of macrophage dysfunction (alterations in phagocytosis) (27). A rise in oxidant production was observed in several tissues of LC patients and in smokers (18,21,22,33). Proteins and DNA are major cellular target components for the action of oxidants that escape the cellular antioxidant systems.…”

Section: Redox Balancementioning

confidence: 99%

“…Oxidative stress, defined as the imbalance between oxidants and antioxidants in favor of the former, represents another relevant contributing factor to LC progression (18)(19)(20)(21)(22)(25)(26)(27)(28)33,36) ( Figure 3). Oxidative and nitrosative stress were shown to favor carcinogenesis through the activation of cellular processes that result in neoplastic transformation, the induction of DNA mutations (32,114), or even through induction of macrophage dysfunction (alterations in phagocytosis) (27).…”

Section: Redox Balancementioning

confidence: 99%

See 3 more Smart Citations

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Barreiro¹,

Bustamante

Curull³

et al. 2016

J. Thorac. Dis.

View full text Add to dashboard Cite

Lung cancer (LC) has become one of the leading causes of preventable death in the last few decades. Cigarette smoking (CS) stays as the main etiologic factor of LC despite that many other causes such as occupational exposures, air pollution, asbestos, or radiation have also been implicated. Patients with chronic obstructive pulmonary disease (COPD), which also represents a major cause of morbidity and mortality in developed countries, exhibit a significantly greater risk of LC. The study of the underlying biological mechanisms that may predispose patients with chronic respiratory diseases to a higher incidence of LC has also gained much attention in the last few years. The present review has been divided into three major sections in which different aspects have been addressed: (I) relevant etiologic agents of LC; (II) studies confirming the hypothesis that COPD patients are exposed to a greater risk of developing LC; and (III) evidence on the most relevant underlying biological mechanisms that support the links between COPD and LC. Several carcinogenic agents have been described in the last decades but CS remains to be the leading etiologic agent in most geographical regions in which the incidence of LC is very high. Growing evidence has put the line forward the implications of COPD and especially of emphysema in LC development. Hence, COPD represents a major risk factor of LC in patients. Different avenues of research have demonstrated the presence of relevant biological mechanisms that may predispose COPD patients to develop LC. Importantly, the so far identified biological mechanisms offer targets for the design of specific therapeutic strategies that will further the current treatment options for patients with LC. Prospective screening studies, in which patients with COPD should be followed up for several years will help identify biomarkers that may predict the risk of LC among these patients.

show abstract

Section: Introductionmentioning

confidence: 62%

Section: Redox Balancementioning

confidence: 88%

Section: Redox Balancementioning

confidence: 99%

Section: Redox Balancementioning

confidence: 99%

See 2 more Smart Citations

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Barreiro¹,

Bustamante

Curull³

et al. 2016

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

“…Subsequently, oxidized substances such MDA is formed. Parallel to this, increased oxidative stress and decreased antioxidant enzymes have been observed in lung cancer patients as the disease progresses (Gupta et al 2010). Schramm et al (2003) reported that natural honey contains numerous antioxidant compounds that delay, prevent or remove oxidative damages (Erejuwa et al 2012).…”

Section: Discussionmentioning

confidence: 99%