Chronic Obstructive Pulmonary Disease and Oxidative Damage

Barreiro, Esther

doi:10.1002/9781119374947.ch10

Cited by 2 publications

(4 citation statements)

References 150 publications

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“…Recently, several authors have proposed different mechanisms leading to this complication. High oxidative stress, malnutrition, airflow obstruction, hypoxemia, and inflammation are some possible factors that can cause muscle dysfunction and impaired structure in COPD ( 8 , 9 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Muscle mass and function are related to respiratory function in chronic obstructive pulmonary disease

Ahmadi

Mazloom

Eftekhari

et al. 2021

mjiri

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Background: Chronic obstructive pulmonary disease (COPD), as an airway limitation condition, is accompanied by alteration of muscle mass and function. We aimed to determine the relationship between disease severity and body composition, muscle function, and nutritional status in COPD patients. Methods: This cross-sectional study was conducted on 129 COPD participants. Muscle strength, body composition, and calf circumference (CC) were measured using a hydraulic hand dynamometer, bioelectrical impedance analysis (BIA), and a tape measure, respectively. Furthermore, fat-free mass index (FFMI), body mass index (BMI) and muscle mass value were calculated by equations. Forced expiratory volume in one second (FEV1) was assessed as well. Nutritional status was also evaluated by subjective global assessment (SGA) questionnaire. SPSS software (version 21 ) was used, chi-square, fisher’s exact test, univariate and multivariate linear regression models were used for statistical analysis. P-values less than 0.05 were considered significant. Results: Based on FEV1 classification, 52.7% of the patients had severe conditions. The reports indicated that the prevalence of low CC was 54.2%, low muscle mass 38.7%, low FFMI 34.8%, low right handgrip strength 61.2% and low left handgrip strength 64.3%. Furthermore, there was an increasing trend based on FEV1 in low CC (p=0.032), low muscle mass (p=0.005), low FFMI (p=0.002), low right handgrip strength (p=0.004) and low left handgrip strength (p=0.014). The results of univariate analysis showed muscle mass (p=0.036), total protein (p=0.043), FFM (p=0.047), FFMI (p=0.007), SGA (p=0.029), right handgrip strength (p=0.004) and left hand grip strength (p=0.023) were associated with FEV1. In addition, the results of multivariate analysis demonstrated low values of FFMI (p=0.005) and right handgrip strength (p=0.042) were the main detrimental factors for FEV1. The results of multivariate analysis were confirmed by stepwise model. Conclusion: Low values of muscle mass and function are prevalent among COPD patients. The present study revealed that low FFMI and handgrip strength were closely related to disease severity.

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Section: Discussionmentioning

confidence: 99%

Muscle mass and function are related to respiratory function in chronic obstructive pulmonary disease

Ahmadi

Mazloom

Eftekhari

et al. 2021

mjiri

View full text Add to dashboard Cite

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“…In addition to having a lower quality of life, the risk is 17 times more than average. 79,80 As the COPD worsens, the body's anaerobic glycolysis of glucose will rise, lactic acid will build up, and metabolic pathway modifications will be triggered, leading to aberrant skeletal muscle function and structure, 49,81 poor standard of living. 77,82 Some of the potential causes of muscle dysfunction and structural damage in COPD include muscle atrophy, muscle fiber type, changed metabolism and remodeling of the chest wall, malnutrition, airflow obstruction, and inflammation.…”

Section: Ffmimentioning

confidence: 99%

“…77,82 Some of the potential causes of muscle dysfunction and structural damage in COPD include muscle atrophy, muscle fiber type, changed metabolism and remodeling of the chest wall, malnutrition, airflow obstruction, and inflammation. 78,79,83,84 TNF-α, interleukin, and other pro-inflammatory factors may be released as a result of muscle atrophy and motor unit loss, 85 but their excessive release will exacerbate structural damage and raise levels of systemic inflammation. 86 Proinflammatory substances including TNF-α and interleukin will also be released due to the decline in protein synthesis and rise in protein breakdown.…”

Section: Ffmimentioning

confidence: 99%

See 1 more Smart Citation

Body Composition and COPD: A New Perspective

Wang¹,

Liang²,

Li³

et al. 2023

COPD

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The proportion of obese or overweight patients in COPD patients is increasing. Although BMI, WC and other easy to measure indicators have been proven to be related to the risk of COPD, they cannot accurately reflect the distribution and changes of body composition, ignoring the body composition (such as fat distribution, muscle content, water content, etc.), the relationship between it and disease risk may be missed. By analyzing the correlation between different body composition indexes and COPD patients, we can provide new research ideas for the prognosis judgment or intervention of COPD disease.

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Chronic Obstructive Pulmonary Disease and Oxidative Damage

Cited by 2 publications

References 150 publications

Muscle mass and function are related to respiratory function in chronic obstructive pulmonary disease

Muscle mass and function are related to respiratory function in chronic obstructive pulmonary disease

Body Composition and COPD: A New Perspective

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