Oxidative stress in liver transplantation with special reference to Santa Casa-SP solution

S, Favero; Soler, Wangles; Iasi, M; Cordovany, T.B.N; Rittes, José Carlos; Szutan, Luiz Arnaldo; Rolin, E.; Capua, Armando De; Mastroti, R.A

doi:10.1016/s0041-1345(03)00339-7

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Liver transplantation can result in complicated pathophysiological changes, including hemorrhage, intensive cycle fluctuations induced by vascular occlusion and opening, intestinal congestion and damage and liver ischemia-reperfusion injury. Trauma caused by these changes activates the systemic oxidative stress and inflammatory reaction, leading to multiple organ complications, ultimately affecting the prognosis of patients undergoing OLT ( 19 – 21 ).…”

Section: Discussionmentioning

confidence: 99%

Ulinastatin ameliorates acute kidney injury following liver transplantation in rats and humans

Chi

et al. 2014

Experimental and Therapeutic Medicine

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Acute kidney injury (AKI) is a common complication following orthotopic liver transplantation (OLT) that evidently affects prognosis. However, no effective treatment exists for AKI. The aim of the present study was to elucidate whether ulinastatin application during OLT in humans can reduce kidney damage and improve renal function. In addition, the underlying mechanisms of ulinastatin were investigated on a rat autologous OLT (AOLT) model. In total, 60 patients undergoing an OLT were randomly selected to receive ulinastatin (U group; n=30) or saline (C group; n=30) during the OLT surgery. The patient demographics, AKI incidence rate, recovery indicators and renal injury indexes were measured during the perioperative period. In addition to the clinical trials, 40 rats were subjected to an AOLT and were divided into the control (C-R), sham-operation and ulinastatin treatment groups. Pathological renal damage, biomarkers of inflammation and oxidative stress were measured to investigate the effects and possible mechanisms of ulinastatin on AKI. In the clinical trials, ulinastatin application was shown to attenuate the incidence of AKI following OLT (P<0.05) and reduce the serum levels of cystatin C and urinary β2 microglobulin within 24 h of the OLT (P<0.05). Furthermore, ulinastatin was found to significantly improve the recovery of patients by reducing the time spent in the intensive care unit (P<0.01 vs. C group), the ventilation time and the hemodialysis rates (P<0.05 vs. C group). In the rat AOLT model, ulinastatin application was also shown to relieve renal pathological damage by reducing the serum cystatin C and creatinine levels. Notably, the levels of tumor necrosis factor-α, interleukin-6, hydrogen peroxide and reactive oxygen species were evidently reduced, while the level of superoxide dismutase was increased in the ulinastatin groups (P<0.05, vs. C-R group). In conclusion, ulinastatin application was demonstrated to protect against AKI following OLT by inhibiting inflammation and oxidation.

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Section: Discussionmentioning

confidence: 99%

Ulinastatin ameliorates acute kidney injury following liver transplantation in rats and humans

Chi

et al. 2014

Experimental and Therapeutic Medicine

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Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation

Jia

Wang

et al. 2017

Brain Research

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Oxidative stress in liver transplantation with special reference to Santa Casa-SP solution

Cited by 2 publications

References 8 publications

Ulinastatin ameliorates acute kidney injury following liver transplantation in rats and humans

Ulinastatin ameliorates acute kidney injury following liver transplantation in rats and humans

Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation

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