Oxidative stress in inflammatory cells of patient with rheumatoid arthritis: clinical efficacy of dietary antioxidants

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease responsible for significant human morbidity in modern life. However, oxidative stress is one of the key markers for determining pathophysiology of patients with RA. The interaction between cellular immune system and body's endogenous and/or exogenous antigens produce reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune disease like RA. ROS and RNS include highly toxic superoxide (O) and peroxynitrite (ONOO) radicals, which activate the signaling cascades of inflammatory cells to synthesize pro-inflammatory cytokines and chemokines. Previous studies reported that Th1 cytokines could promote the development of autoimmune disorders like RA, whereas the Th2 cytokines may attenuate the same diseases. An increased awareness of the relationship between food and health led to a tremendous increase of antioxidant research in the last decade. Evaluation of the efficacy of dietary antioxidants is also becoming highly acceptable in RA research. A number of dietary phytomolecules are already established as having antioxidant activity in isolated synovial cellular infiltrate or peripheral blood neutrophils and lymphocytes. This review aims to highlight the oxidative stress in inflammatory cells of patients with RA and to summarize the clinical relevance of dietary antioxidants as a first step in assessing beneficial effect, safety and dose safety ratio in patients with RA.

Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

“…Over the past several decades, oxidative stress has been found to be involved in the pathogenesis and development of many diseases, including ophthalmic diseases (Nishimura et al, 2017;Pinazo-Duran et al, 2018), diabetes (Rochette et al, 2018), cardiovascular diseases (Luscher, 2015;Munzel et al, 2015;Schiattarella and Hill, 2017), atherosclerosis (Forstermann et al, 2017), arthritis (Bala et al, 2017;Kardes and Karagulle, 2018), dermatological diseases (Rojo de la Vega et al, 2018), respiratory diseases (Hecker, 2018), hepatic diseases (Lee et al, 2019), urinary system diseases (Andersson, 2018), cancer (Poprac et al, 2017), neurodegenerative disorders (Jiang et al, 2016), and other nervous system diseases (D'Amico et al, 2013;Patel, 2016;Pei and Fan, 2017). Moreover, oxidative stress also participates in pathological processes after ICH (Aronowski and Zhao, 2011).…”

Role of Resveratrol in Regulating Cutaneous Functions

“…No benefit [126] Abbreviations: ND, not determined; AQP3, aquaporin 3; SOD, superoxide dismutase; MDA, malondialdehyde; GSH-Px, glutathione peroxidase; GST, glutathione S-transferase; GSH, reduced glutathione; NQO, NAD(P)H:quinone oxidoreductase; ROS: reactive oxygen species; CYP1A1, cytochrome P540 family 1 subfamily A member 1; IKKα, ΙκB kinase α; CYP1B1, cytochrome P540 family 1 subfamily B member 1; COX, cyclooxygenase; ODC, ornithine decarboxylase; NRF2, nuclear factor erythroid 2-related factor 2; ERK: extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; JNK, c-Jun NH2-terminal kinase; TPA, 12-O-tetradecanoyl13-phorbol acetate; DNFB, 2,4-dinitro-1-fluorobenzene; NOS, nitric oxide synthase; VEGF, vascular endothelial growth factor; AMPK, adenosine monophosphate-activated protein kinase. 8 Evidence-Based Complementary and Alternative Medicine antioxidants have been utilized to prevent and treat certain disorders [140][141][142]. Among the antioxidants, benefits of resveratrol have also been studied extensively both in vitro and in vivo.…”

Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C

“…[36][37][38][39] Some studies have demonstrated that diets rich or enriched with antioxidants are useful in preventing functional impairment caused by oxidative stress. [40][41][42] The antioxidant olive oil, which is present in the Mediterranean diet, produces a decrease in the expression of genes implicated in inflammatory and oxidative processes. [43][44][45] Olive oil contains beneficial substances such as polyphenols and monounsaturated fatty acids that have a positive effect on oxygenic metabolism.…”