Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview

Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae

“…Lipid peroxidation and DNA damage, indicators of ROS damage, was increased in the co-exposure group, indicating that oxidative damage occurs in zebrafish larvae exposed to a combination of BDE-209 and Pb. The central nervous system is particularly vulnerable to oxidative stress, as the brain contains high concentrations of polyunsaturated fatty acids that are highly susceptible to lipid peroxidation, and lower activity of antioxidant enzymes, which renders the brain relatively deficient regarding antioxidant protection (Mariani et al, 2005). To further evaluate the contribution of ROS generation to the neurotoxicity induced by co-exposure to BDE-209 and Pb, NAC was added into the BDE-209 and Pb mixture; we observed that NAC eliminated ROS generation induced by exposure to the BDE-209 and Pb combination.…”

Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

“…Being the most active organ in the body, the brain and central nervous system are particularly susceptible to oxidative stress because of high oxygen utilization, low levels of endogenous antioxidant systems and high levels of polyunsaturated fatty acids, which are subject to lipid peroxidation. 79 Increased oxidative stress and free radical production are associated with several neurodegenerative diseases, such as trauma, Alzheimer's disease (AD) and Parkinson's diseases, ischemic stroke and aging. 80 Therapeutic efforts aimed at the removal of ROS or prevention of their formation are considered to be beneficial in neurodegenerative diseases.…”

Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

“…In brain, aging increased the risk of psychiatric disorders and vascular diseases caused by age-related oxidative damage (Mariani et al, 2005;Bell and Guarente, 2011). Sirtuins are highly expressed in brain (Liszt et al, 2005;Michishita et al, 2005), indicating that they may play critical roles in brain development and nervous system (Sakamoto et al, 2004).…”