Oxidative stress in blood of camels (Camelus dromedaries) naturally infected with Trypanosoma evansi

Saleh, Mostafa A.; Al-Salahy, M. Bassam; Sanousi, Samera A.

doi:10.1016/j.vetpar.2009.03.035

Cited by 101 publications

(86 citation statements)

References 40 publications

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“…The anemia observed in the present study come in accordance with those demonstrated previously [7,13]. In the present study, oxidative stress was happened as evidenced by higher level of MDA as lipid peroxidation biomarker and stimulation of antioxidants enzymes to counteract the active free radicals in dromedary camels naturally infected with T. evansi.…”

Section: Discussionsupporting

confidence: 92%

“…Taylor and Authie [9] explain that, the possible causes of Erythrophagocytosis are attributed to damage and increased rate of removal of red cells from the circulation by hemolytic factors released by dying trypanosomes, immune complexes bound to RBCs, together with fever and mechanical damage to RBCs by trypanosomes. Many investigators have shown alterations in hematology of infected camels [10][11][12][13]. Recently, chronic camel trypanosomiasis was associated with a state of oxidative stress process.…”

Section: Introductionmentioning

confidence: 99%

“…The degree of lipid peroxidation is often used as an indicator of ROS mediated damage [17] and the concentration of MDA in blood and tissues are generally used as biomarkers of lipid peroxidation organism, the arising imbalance between pro-and antioxidants is resulted which defined as oxidative stress [19]. Trypanosomiasis in camels resulted in significant increase of serum MDA, significant reduction SOD and non-significant increase in CAT compared to control values [13].…”

Section: Introductionmentioning

confidence: 99%

“…The publications regarding the estimation of the oxidative stress status in T. evansi infection in camels are scarce [13] therefore, additional Biomarkers are required. Therefore, the present study aimed to determine lipid peroxidation, enzymatic antioxidants level and hematological indices in camels naturally infected with Trypanosoma evansi.…”

Section: Introductionmentioning

confidence: 99%

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2015

International Journal of Veterinary Sciences Research

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2015

International Journal of Veterinary Sciences Research

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“…Severity of anemia usually reflects the intensity and duration of parasitaemia as shown by Saleh et al (2009) who also reported acute anemia in trypanosomiasis due to proliferation of the parasites. It has also been reported that infection with trypanosomes may cause increased susceptibility of red blood cell membrane to oxidative damage probably due to reduced glutathione on the surface of red blood cell (Akanji et al, 2009) culminating in severe anemia.…”

Section: Fig 2 Percentage Change In Cholesterol Content Of Parasitimentioning

confidence: 98%

Haemato-Clinical Changes in Pregnant and Non-Pregnant Rats, Rattus rattus Linnaeus, 1758 under Parasitic Stress

2013

Egyptian Journal of Veterinary Sciences

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ERUM chemistry of non-pregnant (Group I) and pregnant (Group …. II) female Rattus rattus (n=389) collected alive from wild conditions in rat traps was investigated in different weight groups (A: 50-100gm, B: 100-150gm and C: 150-200gm) under uninfected and infected (Trypanosoma and Cysticercus) conditions. Groups I and II were further subdivided into four subgroups each, a: Uninfected rats, b: T. lewisi infected rats, c: C. fasciolaris-infected rats, d: T. lewisi and C. fasciolaris-infected rats. A significant maximum fall of 38.01% in glucose was recorded in pregnant rats of Group IIb (weight category B). Changes in cholesterol were insignificant in most of the groups except Group IIc (weight category B) where the fall was maximum (25.32%). Total serum protein (TSP) changes were again insignificant in most of the groups except in weight categories B of Group IIb showing 18.54% rise and Group IIc showing 22.62% fall. Changes were significant (P<0.05) in hemoglobin in parasitized rats showing a maximum fall of 36.63% in Group IIb (weight category B). The results infer that glucose and hemoglobin are the most vulnerable biochemical constituents to parasitism and that older (weight category B and C) pregnant rats (Group II) and rats with dual infection (Group IId) exhibit greater changes in their biochemical constituents.

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First case report on the occurrence of Trypanosoma evansi in a Siam B Mare in Kelantan, Malaysia

Rajdi

Mohamad

Tan

et al. 2020

Veterinary Medicine & Sci

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This is the first case report for the positive Trypanosoma evansi incident in Kelantan, Malaysia confirmed through protozoa detection in a Siam B mare. The horse was presented with complaints of lethargy and inappetence and it collapsed on the day of visit. Normal saline and dextrose solution were administered intravenously, while multivitamins and nerve supplements were given intramuscularly to stabilise the horse before further treatment. Haematological findings showed normocytic hypochromic anaemia and are suggestive of regenerative anaemia. Thin blood smear and examination revealed the presence of Trypanosoma sp., and it was confirmed as T. evansi through molecular identification. The horse was found dead 2 days after and post‐mortem was conducted. Histopathology revealed that the horse had developed a neurological form of the disease, besides the detection of the protozoa in heart, spleen and kidney tissue. This first positive Surra case in Kelantan, Malaysia, that is bordering Thailand confirms the increasing concern of transboundary infections. In conclusion, Surra is a potential emerging disease and should be considered as differential diagnosis in horses with pale mucous membrane. This condition is particularly imperative in horses found in these regions as Surra is endemic.

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Oxidative stress in blood of camels (Camelus dromedaries) naturally infected with Trypanosoma evansi

Cited by 101 publications

References 40 publications

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Haemato-Clinical Changes in Pregnant and Non-Pregnant Rats, Rattus rattus Linnaeus, 1758 under Parasitic Stress

First case report on the occurrence of Trypanosoma evansi in a Siam B Mare in Kelantan, Malaysia

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