Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis

Sebastiano, Manrico; Chastel, Olivier; Thoisy, Benoı̂t de; Eens, Marcel

doi:10.1093/cz/zow019

Cited by 44 publications

(39 citation statements)

References 52 publications

(52 reference statements)

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“…Viral infections are promoted by oxidative processes, the latter acting on replication in infected cells, cell proliferation inhibition and cell apoptosis induction [5]. In patients affected by herpes simplex [6], it was observed that an increase of the ROS-induced membrane phospholipids peroxidation caused dysfunction of vital cellular processes such as membrane transport and mitochondrial respiration [7]. Epstein-Barr Virus (EBV) infections cause an increase in DNA damage and significant ROS accumulation, and, interestingly, treatment with ROS scavengers was able to lower DNA damage in both mitogen-stimulated and EBV-infected cells [8].…”

Section: Introductionmentioning

confidence: 99%

Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases

et al. 2020

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As the COVID-19 epidemic expands in the world, and with the previous SARS epidemic, avian flu, Ebola and AIDS serving as a warning, biomedical and biotechnological research has the task to find solutions to counteract viral entry and pathogenesis. A novel approach can come from marine chemodiversity, recognized as a relevant source for developing a future natural "antiviral pharmacy". Activities of antioxidants against viruses can be exploited to cope with human viral infection, from single individual infections to protection of populations. There is a potentially rich and fruitful reservoir of such compounds thanks to the plethora of bioactive molecules and families present in marine microorganisms. The aim of this communication is to present the state-of-play of what is known on the antiviral activities recognized in (micro)algae, highlighting the different molecules from various algae and their mechanisms of actions, when known. Given the ability of various algal molecules-mainly sulfated polysaccharides-to inhibit viral infection at Stage I (adsorption and invasion of cells), we envisage a need to further investigate the antiviral ability of algae, and their mechanisms of action. Given the advantages of microalgal production compared to other organisms, the opportunity might become reality in a short period of time.

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Section: Introductionmentioning

confidence: 99%

Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases

et al. 2020

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Sebastiano, M. et al (2016) High levels of mercury and low levels of persistent organic pollutants in a tropical seabird in French Guiana, the Magnificent frigatebird, Fregata magnificens. Environmental Pollution, 214, pp.

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confidence: 99%

High levels of mercury and low levels of persistent organic pollutants in a tropical seabird in French Guiana, the Magnificent frigatebird, Fregata magnificens

Sebastiano

Bustamante

Costantini

et al. 2016

Environmental Pollution

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Sebastiano, M. et al. (2016) High levels of mercury and low levels of persistent organic pollutants in a tropical seabird in French Guiana, the Magnificent frigatebird, Fregata magnificens. Environmental Pollution, 214, pp. 384-393. (doi:10.1016Pollution, 214, pp. 384-393. (doi:10. /j.envpol.2016 This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/121333/ In the present study, trace elements and persistent organic pollutants (POPs) were quantified 26 from Magnificent frigatebirds (Fregata magnificens) breeding at a southern Atlantic island. 27Stable isotope ratio of carbon (δ 13 C) and nitrogen (δ 15 N) were also measured to infer the role 28 of foraging habitat on the contamination. For another group from the same colony, GPS tracks 29 were recorded to identify potential foraging areas where the birds may get contaminated. Capsule abstract 50In the present study we found high levels of mercury and low levels of persistent organic 51 pollutants in a tropical seabird breeding in a protected area. 52 53

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“…Epstein‐Barr virus (EBV) has been linked to MS, and it is known to increase OS and promote MtD . Human herpes 6 (HHV6) has been linked to MS, and it is well known to increase OS . Smoking has been linked to MS, and several lines of evidence indicate that it promotes OS and MtD .…”

Section: Elucidation Of the Role Of Oxidative Stress (Os) And Mitochomentioning

confidence: 99%

On elucidation of the role of mitochondria dysfunction and oxidative stress in multiple sclerosis

Tobore

2019

Neurology & Clinical Neurosc

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Multiple sclerosis (MS) is a complex human neurodegenerative dysimmune disease of the central nervous system (CNS) which is characterized by chronic inflammation, demyelination, loss of blood‐brain barrier (BBB) integrity, neuronal loss, reactive astrogliosis, and oligodendrocyte depletion. It can result in physical disability and severe neurological and cognitive deficits. Research indicates that MS prevalence has significantly increased in many regions around the world since 1990. The specific elements that trigger MS remain unknown. In this paper, the critical role played by mitochondria dysfunction and oxidative stress in MS pathogenesis, progression, and clinical symptoms are elucidated. Their interactions with the key factors in the disease, as well as treatment strategies, are discussed.

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Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis

Cited by 44 publications

References 52 publications

Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases

Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases

High levels of mercury and low levels of persistent organic pollutants in a tropical seabird in French Guiana, the Magnificent frigatebird, Fregata magnificens

On elucidation of the role of mitochondria dysfunction and oxidative stress in multiple sclerosis

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