Oxidative stress effects in the uterus, placenta and fetus of pregnant rats submitted to acute and chronic stress

Silveira, Adriano Silva; Aydos, Ricardo Dutra; Ramalho, Rondon Tosta; Silva, Iandara Schettert; Caldas, Ruy de Araujo; Neto, Abilio Torres dos Santos; Rodrigues, Camila Tozaki

doi:10.1590/s0102-865020180090000009

Cited by 10 publications

(8 citation statements)

References 26 publications

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“…In a molecular way, oxidative stress, promoted by the establishment of a chronic stress condition, modifies signaling events of different cells, including the regulation of mitogen-activated protein kinases (MAP kinases), intra-cellular calcium levels, and transcription factors [8,30,31]. In this sense, the production of EROS modulates bone metabolism from undifferentiated osteoclastic precursor cells, altering the activities of osteoblastic formation and osteoclastic bone resorption, favoring the creation of a pro-resorptive environment.…”

Section: Discussionmentioning

confidence: 99%

Blood Oxidative Stress Modulates Alveolar Bone Loss in Chronically Stressed Rats

Castro

Nascimento

Souza-Monteiro

et al. 2020

IJMS

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We aimed to investigate the effects of chronic stress (CS) on experimental periodontitis (EP) in rats. For this, 28 Wistar rats were divided into four groups: control, ligature-induced experimental periodontitis (EP), chronic stress (CS; by physical restraint model) and CS+EP (association of chronic stress and ligature-induced periodontitis). The experimental period lasted 30 days, including exposure to CS every day and ligature was performed on the 15th experimental day. After 30 days, the animals were submitted to the behavioral test of the elevated plus maze (EPM). Next, rats were euthanized for blood and mandible collection in order to evaluate the oxidative biochemistry (by nitric oxide (NO), reduced-glutathione activity (GSH), and thiobarbituric acid reactive substance levels (TBARS)) and alveolar bone characterization (by morphometric, micro-CT, and immunohistochemistry), respectively. The behavioral parameters evaluated in EPM indicated higher anxiogenic activity in the CS and CS+EP, groups, which is a behavioral reflex of CS. The results showed that CS was able to change the blood oxidative biochemistry in CS and CS+EP groups, decrease GSH activity in the blood, and increase the NO and TBARS concentrations. Thus, CS induces oxidative blood imbalance, which can potentialize or generate morphological, structural, and metabolic damages to the alveolar bone.

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Section: Discussionmentioning

confidence: 99%

Blood Oxidative Stress Modulates Alveolar Bone Loss in Chronically Stressed Rats

Castro

Nascimento

Souza-Monteiro

et al. 2020

IJMS

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“…The association between preeclampsia and oxidative stress has also been demonstrated in animal studies [50,51]. A study by Beauséjour et al determined whether maternal disturbances in pregnancy lead to placental oxidative stress.…”

Section: Oxidative Stress In Preeclampsiamentioning

confidence: 95%

The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus)

Phoswa

Khaliq

2021

Oxidative Medicine and Cellular Longevity

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Purpose of the Review.To highlight the role of oxidative stress in hypertensive disorders of pregnancy (HDP) and metabolic disorders of pregnancy (gestational diabetes mellitus). Recent Findings. In both preeclampsia (PE) and gestational hypertension (GH), oxidative stress leads to inadequate placental perfusion thus resulting in a hypoxic placenta, which generally leads to the activation of maternal systemic inflammatory response. In PE, this causes inflammation in the kidneys and leads to proteinuria. A proteinuria marker known as urinary 8-oxoGuo excretion is expressed in preeclampsia. In GDM, oxidative stress plays a role in the pathogenesis of the disease, as a result of over secretion of insulin during pregnancy. This uncontrolled secretion of insulin results in the production of lipid peroxidation factors that also mask the secretion of antioxidants. Therefore, ROS becomes abundant at cellular level and prevents the cells from transporting glucose to body tissues. Summary. There is a need for more research investigating the role of oxidative stress, especially in obstetrics-related conditions. More studies are required in order to understand the difference between the pathogenesis and pathophysiology of PE versus GH since investigations on the differences in genetic aspects of each condition are lacking. Furthermore, research to improve diagnostic procedures for GDM in pregnancy is needed.

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“…Excessive oxidative stress as a result of an increase in the level of free radicals, especially ROS and hydroxyl, and a decrease in the activity and efficiency of antioxidants within the uterine tissue and the placenta. This gives an important explanation for many cases of pregnancy failure and defects in the growth and development of fetuses during and after pregnancy in a certain period (Silveira et al, 2018;Wu et al, 2017(. For the purpose of inducing oxidative stress in rats, Desferal was used in a high dose for two consecutive weeks. Injecting intraperitoneal resulted in oxidative stress induced through apparent changes in the levels of oxidative markers.…”

Section: Discussionmentioning

confidence: 99%

Induced Oxidative Stress by Deferoxamine (Desferal) During the Pregnancy: Pre and Post-Natal Developmental Study

Thanoon¹,

Alchalabi²

2021

Mesopotamia Journal of Agriculture

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The aim of the study is to evaluate the effect of induced oxidative stress by the deferoxamine (desferal) during the pregnancy on pre and post-natal developmen. One hundred twenty adult female albino rats, 3 months old, with an average weight of 175-200 g, were randomly distributed into two main groups (60 rats/group). The 1st (control group) was injected with 0.3 ml physiological salt solution / animal, and the 2nd group was injected with 100 mg deferral/kg B.W. which was given intraperitoneal once daily for three consecutive weeks (during the pregnancy period). At the end of the treatment, each group in turn was divided into two parts, each section comprising 10 animals, blood samples were collected for biochemical analysis, then uterine and fetal tissues collected to observation the studied parameters. Results showed decrease in the numbers of implantation and blastocysts. The number of alive embryos were significantly reduced with an increasing number of dead and reabsorbed embryos, malformation of fetus increase in uterine of the stressed female group compared with control group. Postnatal observations showed significant variations in postnatal development parameters. Our study suggests that the deferral injection has a pro-oxidant capacity on rats' model at dose of 100 mg/kg, and the oxidative stress plays an important role during pregnancy especially on prenatal development as well as persist up to postnatal life.

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Oxidative stress effects in the uterus, placenta and fetus of pregnant rats submitted to acute and chronic stress

Cited by 10 publications

References 26 publications

Blood Oxidative Stress Modulates Alveolar Bone Loss in Chronically Stressed Rats

Blood Oxidative Stress Modulates Alveolar Bone Loss in Chronically Stressed Rats

The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus)

Induced Oxidative Stress by Deferoxamine (Desferal) During the Pregnancy: Pre and Post-Natal Developmental Study

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