Oxidative Stress Correlates with More Aggressive Features in Thyroid Cancer

Muzza, Marina; Pogliaghi, Gabriele; Colombo, Carla; Carbone, Erika; Cirello, Valentina; Palazzo, Salvatore; Frattini, Francesco; Gentilini, Davide; Gazzano, Giacomo; Persani, Luca; Fugazzola, Laura

doi:10.3390/cancers14235857

Cited by 17 publications

(27 citation statements)

References 33 publications

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“…Several studies have investigated the relationship between inflammation, oxidative stress, and thyroid cancer [ 34 – 36 ]. In particular, chronic inflammation is linked to oxidative stress, which can cause DNA damage and thus contribute to the accumulation of cancer-initiating genetic alterations in cells [ 35 ].…”

Section: Endocrine Axes and The Mediterranean Dietmentioning

confidence: 99%

“…For instance, a recent study found out that the serum levels of malondialdehyde, a well-established marker for screening and monitoring the oxidation stress level, were significantly higher in 55 patients with differentiated thyroid cancer compared to the healthy subjects [ 34 ]. Another study investigated the levels of ROS in 50 malignant and benign thyroid lesions and 41 normal tissues and correlated them with the thyroid differentiation score and the clinic-pathologic features [ 36 ]. In both malignant and benign thyroid tissue, the production of ROS and expression of the NADPH oxidase 4 (NOX4), a significant source of ROS, playing an important role in tumor cell proliferation and apoptosis, were found to be higher than in healthy tissues [ 36 ].…”

Section: Endocrine Axes and The Mediterranean Dietmentioning

confidence: 99%

“…Another study investigated the levels of ROS in 50 malignant and benign thyroid lesions and 41 normal tissues and correlated them with the thyroid differentiation score and the clinic-pathologic features [ 36 ]. In both malignant and benign thyroid tissue, the production of ROS and expression of the NADPH oxidase 4 (NOX4), a significant source of ROS, playing an important role in tumor cell proliferation and apoptosis, were found to be higher than in healthy tissues [ 36 ]. Follicular thyroid cancers (FTCs) and anaplastic/poorly differentiated cancers exhibited greater oxidative stress compared to papillary thyroid tumors (PTCs) [ 36 ].…”

Section: Endocrine Axes and The Mediterranean Dietmentioning

confidence: 99%

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Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist

Barrea,

Verde,

Annunziata

et al. 2023

J Endocrinol Invest

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Purpose The purpose of this review is to examine the current evidence on the potential role of Mediterranean diet (MD) in the prevention and management of endocrine disorders and to highlight the importance of interdisciplinary collaboration between endocrinologists and nutritionists. Methods A literature search was conducted using PubMed and Google Scholar databases to identify relevant studies published in English. Studies were selected based on their relevance to the role of MD in the prevention and management of endocrine disorders. The search terms included "Mediterranean diet," "endocrine disorders," "thyroid disorders," "gonadal disorders," and "neuroendocrine tumors". Results The studies reviewed suggest that MD may have a beneficial effect in the prevention and management of various endocrine disorders, including thyroid disorders, gonadal disorders, and neuroendocrine tumors. MD has been associated with decreased risk of nodular thyroid disease and thyroid cancer, improved male and female reproductive health, and a potential role in the management of neuroendocrine tumors. MD's anti-inflammatory and antioxidant properties, as well as its high levels of phytochemicals, may play a role in its beneficial effects. Conclusion Interdisciplinary collaboration between endocrinologists and nutritionists is essential for the optimal management of endocrine disorders, including the potential role of MD in their prevention and management. While further research is needed, the current evidence suggests that MD may have a protective effect against endocrine disorders, and its incorporation into dietary recommendations may be beneficial.

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Section: Endocrine Axes and The Mediterranean Dietmentioning

confidence: 99%

Section: Endocrine Axes and The Mediterranean Dietmentioning

confidence: 99%

Section: Endocrine Axes and The Mediterranean Dietmentioning

confidence: 99%

See 1 more Smart Citation

Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist

Barrea,

Verde,

Annunziata

et al. 2023

J Endocrinol Invest

View full text Add to dashboard Cite

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“…Oxidative stress is a risk factor for thyroid cancer [20,26,27], and it correlates with more aggressive features because ROS may repress genes involved in thyroid differentiation [28]. The antioxidant protection system of undifferentiated thyroid stem cells may therefore be important to preserve their normal biology, regulating the balance between stemness maintenance and the activation of self-renewal and differentiation [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Defense Capacity Is Reduced in Thyroid Stem/Precursor Cells Compared to Differentiated Thyrocytes

Gianì

Allia

Trovato

et al. 2023

IJMS

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There is much evidence linking oxidative stress to thyroid cancer, and stem cells are thought to play a key role in the tumor-initiating mechanism. Their vulnerability to oxidative stress is unexplored. This study aimed to comparatively evaluate the antioxidant capacity of stem/precursor thyroid cells and mature thyrocytes. Human stem/precursor cells and mature thyrocytes were exposed to increasing concentrations of menadione, an oxidative-stress-producing agent, and reactive oxygen species (ROS) production and cell viability were measured. The expression of antioxidant and detoxification genes was measured via qPCR as well as the total antioxidant capacity and the content of glutathione. Menadione elevated ROS generation in stem/precursor thyroid cells more than in mature thyrocytes. The ROS increase was inversely correlated (p = 0.005) with cell viability, an effect that was partially prevented by the antioxidant curcumin. Most thyroid antioxidant defense genes, notably those encoding for the glutathione-generating system and phase I detoxification enzymes, were significantly less expressed in stem/precursor thyroid cells. As a result, the glutathione level and the total antioxidant capacity in stem/precursor thyroid cells were significantly decreased. This reduced antioxidant defense may have clinical implications, making stem/precursor thyroid cells critical targets for environmental conditions that are not detrimental for differentiated thyrocytes.

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“…Healthy cells, thereby subjected to chronic oxidative stress, can be transformed into cancer cells, through the mechanism presented above. Tumor cell survival, proliferation, chemoresistance, radioresistance, invasion, angiogenesis and stem cell survival are caused in the same way [ 11 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Cytotoxic Activity of New Polyphenolic Derivatives of Quinazolin-4(3H)-one: Synthesis and In Vitro Activities Evaluation

et al. 2022

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The development of hybrid molecules with significant human therapeutic properties is one of the main approaches of pharmaceutical research. One of the most important pharmacophores is the quinazolin-4(3H)-one heterocycle moiety, due to its wide range of biological activities. By its derivatization with polyphenolic compounds, in our previous research, it proved to possess a good antiradical activity of ortho-diphenolic derivatives of quinazolin-4(3H)-one. In this study, we developed two new series of compounds, with an additional phenolic group or with a methyl group on the thioacetohydrazone fragment. The methods used to evaluate the activity of the compounds were radical scavenging, reduction of oxidizing reagents and transition metals’ ions chelation assays. Quantum descriptors were also calculated in order to evaluate the influence of substituents and their position on the activity of the compounds. The cytotoxic activity was evaluated using normal human foreskin fibroblast cells (BJ) and two cancerous cell lines, lung adenocarcinoma cells (A549) and prostate carcinoma cells (LNCaP). The results obtained for the pyrogallol derivatives showed a high antioxidant activity compared to ascorbic acid and Trolox. All the synthesized compounds displayed a higher cytotoxicity against the cancerous cell types and a high cytocompatibility with the normal cells. The antioxidant activity was deeply influenced by the addition of the third phenolic group in the synthesized molecules.

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Oxidative Stress Correlates with More Aggressive Features in Thyroid Cancer

Cited by 17 publications

References 33 publications

Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist

Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist

Antioxidant Defense Capacity Is Reduced in Thyroid Stem/Precursor Cells Compared to Differentiated Thyrocytes

Antioxidant and Cytotoxic Activity of New Polyphenolic Derivatives of Quinazolin-4(3H)-one: Synthesis and In Vitro Activities Evaluation

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