Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes

Abstract

Reactive oxygen species, such as hydrogen peroxide, are responsible for the alveolar bone loss accompanied by decreased endothelial nitric oxide synthase expression in KK-A(y) mice. Therefore, we propose a working hypothesis that the generation of oxidative stress is an underlying systemic condition that enhances alveolar bone loss in periodontitis occurring as a complication of diabetes.

Peri-implant Diseases

“…In addition, an increased formation and accumulation of advanced glycation end-products in the periodontal tissues raises cellular oxidative stress and increases the production of proinflammatory cytokines (such as IL-6, IL-1b, IL-18, matrix metalloproteinase [MMP]-8 and MMP-9) in the serum, saliva, and gingival crevicular fluid of patients with chronic hyperglycemia. 68,[70][71][72][73] These proinflammatory cytokines may jeopardize the osseointegration and long-term survival of implants in patients with chronic hyperglycemia. However, it is pertinent to mention that degree of glycemic control (in patients previously diagnosed with diabetes) may play a role in a successful osseointegration and survival of implants in diabetic patients.…”

Risque parodontal chez le patient obèse

“…Dans la lésion parodontale, l'expression des gènes relatifs à la détoxification xénobiotique serait diminuée pour le rat obèse [44]. Enfin, les ROS seraient responsables de la perte osseuse alvéolaire, accompagnés d'une diminution de la production d'oxyde nitrique synthé-tase endothéliale (eNOS), agent antioxydant, chez les souris KK-Ay, modèles de syndrome métabolique et de diabète de type 2 [45]. Ainsi, le stress oxydatif lors de maladie parodontale, reflété par une forte concentration de ROS et accompagné d'une suppression de l'activité antioxydante, pourrait accélérer la formation de lésions parodontales et augmenter la perte osseuse alvéolaire.…”

Antioxidants In Dentistry: Review Of Literature

“…According to Ohnishi et al [22] reactive oxygen such as hydrogen peroxide, are responsible for the alveolar bone loss that is accompanied by decreased endothelial nitric oxide synthase expression in mice and they stated that the generation of oxidative stress is an underlying systemic condition that enhances alveolar bone loss. Peri-implantitisis initiated by gram negative, anaerobic bacteria that accomodates in the subgingival area.…”