Oxidative Stress Caused by Lithium Exposure in the Carassius auratus (goldfish) Liver Tissue

Abstract

Lithium is a therapeutic agent widely used in the treatment of some psychiatric disorders. The aim of this study was to investigate the effects lithium-induced oxidative stress in liver tissue. In this study, Carassius auratus fish was used as a model organism and total 20 control fish and 28 experimental fishes were divided 4 subgroups randomly. Lithium chloride at a concentration of 50 mg/L was added to the glass tank of the experimental group. Fish were placed in two separate glass tanks, 20 in the control group and 28 in the experimental group. Lithium chloride at a concentration of 50 mg/L was added to the glass tank, which is the experimental group. At the 24th, 48th, 72nd and 96th hours of the study, 5 samples from the control group and 7 samples from the experimental group were included in the study in four different time periods. At the end of the study, it was determined that the level of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and acetylcholinesterase(AchE) decreased in the group with lithium exposure, while the levels of Malondialdehyde (MDA) increased. It was determined that oxidative stress occurred in lithium exposure.