Oxidative stress biomarkers as indicator of chronic inflammatory joint diseases stage

Feijóo, Montserrat; Túnez, Isaac; Ruíz, A Trujillano; Tasset, Inmaculada; Muñoz, Elisa; Collantes, Eduardo

doi:10.1016/s2173-5743(10)70020-4

Cited by 15 publications

(15 citation statements)

References 15 publications

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“…Feijoo et al [52] observed that myeloperoxidase levels are elevated in patients with chronic inflammatory disease, especially those with active disease, and that high myeloperoxidase levels are related to an increase in oxidative damage and the inflammatory response, for myeloperoxidase and GR seem to show a similar activity pattern based on the availability of NADPH. Erythrocyte GSH and glutathione reductase levels rise in healthy individuals exposed to chronic oxidative stress [53].…”

Section: Mdamentioning

confidence: 99%

Antioxidant Enzymes in Rheumatoid Arthritis

Kumar¹,

Prakash²,

Gupta³

et al. 2016

J Arthritis

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Joint destruction in rheumatoid arthritis (RA) is due to tissue injury in the area caused by inflammatory reactions, release of MMPs and free radicals produced by neutrophils and macrophages. The control of free radical production may have therapeutic roles thus the study was done to check the status of lipid peroxidation product malondialdehyde (MDA) and a few antioxidant enzymes in RA patients. 45 RA patients and 40 controls were selected. Controls were asymptomatic and RA patients were selected according to ACR criteria. RA patients had significantly high MDA, SOD and ALP and reduced activity of catalase and GR as compared to controls. SOD showed positive correlation with ALP. GR was positively related with MDA, SOD and ALP. The study shows that MDA is involved in the pathogenesis of RA. The system is trying to quench free radicals by high SOD activity. Higher production of H 2 O 2 or some other mechanism is responsible for inhibition of catalase and GR. However system is trying to reduce the damage by neutralizing superoxide anion. Therapeutic intervention of the oxidative stress may be considered for effective control of inflammation in RA patients.

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Section: Mdamentioning

confidence: 99%

Antioxidant Enzymes in Rheumatoid Arthritis

Kumar¹,

Prakash²,

Gupta³

et al. 2016

J Arthritis

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“…Free radicals such as reactive oxygen species (ROS) and reactive nitrogen species have seriously damaging effects on biological macromolecules such as lipids, proteins, DNA, and carbohydrates that constitute the cellular components [9][10][11][12][13]. As a prominent example, free radicals damage liver leading to acute and chronic hepatic injury [14,15]. Hepatotoxic effect of carbon tetra chloride (CCl 4 ), a potent free radical is the result of its biotransformation to trichloromethyl free radical (CCl 3 ) or trichloroperoxyl radical (CCl 3 O 2 ) by the mixed-function cytochrome P 450 oxygenase system of the endoplasmic reticulum that causes oxidative stress and membrane damage characterized by atrophy of parenchyma, necrosis and degeneration [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant Potential and Hepatoprotective Activity of Taxus Wallichiana

Bhat

Ganie

Dar

et al. 2018

Asian J Pharm Clin Res

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Objectives: Taxus wallichiana, the member of family Taxaceae is used for the cure of various ailments by a large ethnic population native to the forests in Kashmir valley. The aim of this study is to evaluate antioxidant potential and hepatoprotective action of T. wallichiana as claimed by the ethnic population segment.Methods: Antioxidant potential of different T. wallichiana extracts was evaluated by estimating the total phenolics, 1,1-diphenyl -2-picrylhydrazyl (DPPH), reducing power, microsomal lipid peroxidation (LPO), and hydroxyl radical scavenging activity through standard protocols. Hepatoprotective activity of T. wallichiana was determined by evaluation of liver marker enzyme (aspartate transaminase, alanine transaminase, and alkaline phosphatase) levels using standard protocols and by histological analysis of rat liver tissues of different animal groups against CCl 4 induced liver damage.Results: Phenolic content expressed as gallic acid equivalents (GAE/g) was found maximum in case of ethanolic extract (153.34 mg GAE/g), followed by extracts of methanol (149.24 mg GAE/g), hexane (134 mg GAE/g), ethyl acetate (128.9 mg GAE/g), chloroform (121.37 mg GAE/g), and aqueous (113.00 mg GAE/g). At concentration of 700 µg/ml, DPPH radical scavenging activity of methanol extract was 88.29% with IC 50 (212.00 µg/ml), aqueous (82.47%) with IC 50 (258.29 µg/ml), and ethyl acetate (79.57%) with IC 50 (301.80%µg/ml). The reducing power of the extracts increased in a concentration dependent manner. At concentration of 700 µg/ml, 79%, 68%, and 56% inhibition was observed with extracts of methanol, aqueous, and ethyl acetate on microsomal LPO with IC 50 values of 126.09, 168.83, and151.96 µg/ml, respectively. Superoxide radical scavenging activity of T. wallichiana extracts increased in a dose-dependent manner with IC 50 values 170.30 µg/ml (methanol), 257.00 µg/ml (aqueous), and 297.55 µg/ml ethyl acetate extract. T. wallichiana extracts exhibited antioxidant effects on calf thymus DNA damage. The results further depict the hepatoprotective action of T. wallichiana extract at doses of 100 and 300 mg/kg and were comparable with that of standard treatment comprising 50 mg/kg-day of Vitamin C, a known hepatoprotective agent. The data were substantiated with histopathological studies of rat liver sections. Conclusion:These results comprehensively depict that T. wallichiana extracts are endowed with the free radical sequestering potential and be employed as potential antioxidant and hepatoprotective arsenal against many oxidative stress linked diseases.

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“…It is exposed to a variety of xenobiotics such as drugs, toxic chemical products, and environmental pollutants. Such substances lead to the production of reactive oxygen and nitrogen species, which promotes the development of several diseases (Feijóo et al, ; Lima et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Such substances lead to the production of reactive oxygen and nitrogen species, which promotes the development of several diseases (Feijóo et al, 2010;Lima et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl ₄ ‐induced hepatotoxicity in Wistar rats

et al. 2018

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The current study evaluated the antioxidant and hepatoprotective potential of the lyophilized extract of acerola bagasse (EAB), which is a residue from the processing of the fruit (rich in phenolic compounds), against the toxic action of carbon tetrachloride (CCl4) in Wistar rats. The rats were divided into six groups of six animals and received the treatments by gavage once a day, for 21 days. The treatments with EAB containing 7 and 14 mg of phenolic compounds/kg animal weight (AW) presented a decrease in the activity of aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase, and an increase in superoxide dismutase, total antioxidant capacity and albumin content in relation to treatment with water and CCl4. It is concluded that the EAB has antioxidant and hepatoprotective action, at doses of 7 and 14 mg of phenolic compounds/kg AW, with possible applications in pharmaceutical, cosmetics, and food industries. Practical application Agro‐industrial wastes are promising sources of phytochemicals beneficial to health, as the phenolic compounds. Phenolic compounds prevent the action of reactive species in the human body, as well as the onset of various diseases. In this study, extract of acerola bagasse possess antioxidant and hepatoprotective actions due to the presence of phenolic compounds. The extract was able to reduce the levels of alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transferase and increase in total antioxidant levels in plasma. Thus, the acerola bagasse is a source phenolic compounds, whose extract might be able to fight reactive oxygen and nitrogen species.

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Oxidative stress biomarkers as indicator of chronic inflammatory joint diseases stage

Cited by 15 publications

References 15 publications

Antioxidant Enzymes in Rheumatoid Arthritis

Antioxidant Enzymes in Rheumatoid Arthritis

In Vitro Antioxidant Potential and Hepatoprotective Activity of Taxus Wallichiana

Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl ₄ ‐induced hepatotoxicity in Wistar rats

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Oxidative stress biomarkers as indicator of chronic inflammatory joint diseases stage

Cited by 15 publications

References 15 publications

Antioxidant Enzymes in Rheumatoid Arthritis

Antioxidant Enzymes in Rheumatoid Arthritis

In Vitro Antioxidant Potential and Hepatoprotective Activity of Taxus Wallichiana

Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl 4 ‐induced hepatotoxicity in Wistar rats

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Product

Resources

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Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl ₄ ‐induced hepatotoxicity in Wistar rats