Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium

Djurić, Ana; Begić, Aida; Gobeljić, Borko; Stanojević, Ivan; Ninković, Milica; Vojvodić, Danilo; Pantelić, Ana; Zebić, Goran; Prokić, Vera; Dejanović, Bratislav; Stojanović, Ivana; Pavlica, Marina; Djukić, Dušan Lj.; Saso, Luciano; Djurdjević, Dragan; Pavlović, Marija; Topić, Aleksandra; Vujanović, Dragana; Stevnovic, Ivana; Djukić, Mirjana

doi:10.1016/j.fct.2015.09.004

Cited by 49 publications

(37 citation statements)

References 55 publications

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“…There was significant increase in lipid oxidation byproduct, MDA level. This was the same as found by different research [25,26] in the pituitary gland and on other tissues [27][28][29].…”

Section: Discussionsupporting

confidence: 75%

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Ek¹,

Mf²,

Mg³

et al. 2017

IJCPT

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Adult male Sprague rats weighting (220 ± 30gm) were purchased from Faculty of Agriculture, Minia University Egypt. Experimen- AbstractCadmium (Cd) is a common environmental hazardous heavy metal. The standard treatment of heavy metal intoxication; chelators may have a minor role in Cd toxicity. Montelukast (ML) is an anti-inflammatory drug that is used mainly for managing asthmatic patients. Recent workers have tested ML for its antioxidant properties in various conditions and obtained encouraging results as regarding this effect. We investigated the protective and antioxidant effect of ML on pituitary gland, a highly sensitive organ to Cd toxicity. Four groups of rats were used and received distilled water, 10mg/kg ML, 3mg/kg Cd, and 10mg ML plus 3mg/kg Cd respectively. Antioxidant, histological, immunohistochemical and hormonal effects of Cd and ML were evaluated. The detrimental effect of Cd on pituitary gland was abolished by ML. The diminished hormonal effect of Cd was restored to normal levels. The increased MDA level and depleted oxidative enzymes on pituitary gland of rat exposed to Cd were restored by ML. lastly, histological and apoptotic effects of Cd were also, corrected significantly by ML. It is concluded that ML can protect against Cd-induced pituitary gland toxicity.

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“…There was significant increase in lipid oxidation byproduct, MDA level. This was the same as found by different research [25,26] in the pituitary gland and on other tissues [27][28][29].…”

Section: Discussionsupporting

confidence: 75%

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Ek¹,

Mf²,

Mg³

et al. 2017

IJCPT

View full text Add to dashboard Cite

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“…Cd forms a complex with the ‐SH group that maintains the tertiary structure of G6PD to reduce its activity and further reduce the production of NADPH, which in turn reduces GR activity. Cd inhibits GST synthesis in the liver and kidney and results in the disappearance of isozyme while increasing GST activity in the monkey . Related studies have shown that Cd increases testicular GST activity, although it does not affect GSH levels, indicating that GST is detoxified via the GSH cycle induced by Cd .…”

Section: Cd‐induced Toxicitymentioning

confidence: 99%

Cytoprotective effects of dietary flavonoids against cadmium‐induced toxicity

Jiang

Sun

et al. 2017

Annals of the New York Academy of Sciences

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Cadmium (Cd) damages the liver, kidney, bones, reproductive system, and other organs. Flavonoids, such as anthocyanins and flavonols, which are commonly found in plant foods, have shown protective effects against Cd-induced damage. The cytoprotective effects of flavonoids against Cd-induced diseases are mainly attributable to three mechanisms. First, flavonoids clear reactive oxygen species, thereby reducing lipid peroxide production and improving the activity of antioxidation enzymes. Second, flavonoids chelate Cd, thus reducing the accumulation of Cd and altering the levels of other essential metal ions in vivo. Third, flavonoids reduce DNA damage and inhibit apoptosis. In addition, flavonoids were found to inhibit inflammation and fibrosis and improve glycometabolism and the secretion of reproductive hormones. We introduce the daily dosage and absorption rate of flavonoids and then focus on their bioactive effects against Cd-induced toxicity and reveal the underlying metabolic pathway, which provides a basis for further study of the nutritional prevention of Cd-induced injury. In particular, a better understanding is needed of the structure-activity relationship of flavonoids against Cd toxicity, which has not yet been reported.

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“…This imbalance leads to an increase in ROS, which damages the cell membrane lipids, leading to lipid peroxidation by the formation of malondialdehyde (MDA). It has been demonstrated that oxidative stress is generally enhanced in the tissues of the animals with zinc deficiency and copper abundance [10].…”

Section: Introductionmentioning

confidence: 99%

Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome

et al. 2016

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Objectives: The present study aims to investigate the role of oxidant-antioxidant status in young women with polycystic ovary syndrome (PCOS). Material and methods:Seventy-one women with PCOS and 53 healthy controls are compared in aspect of demographic characteristics, biochemical data, hormones, and oxidant-antioxidant status. Results:The PCOS group had significantly lower zinc, higher malondialdehyde and gluthathione peroxidase and lower serum catalase levels than the control group (p = 0.016, p < 0.001, p = 0.043 and p = 0.025 respectively). The PCOS patients with IR had significantly higher malondialdehyde, lower catalase and serum zinc levels than the PCOS patients without IR (p = 0.015, p = 0.010, p = 0.001 respectively). The infertile PCOS patients had significantly higher malondialdehyde, lower catalase and serum zinc levels than the fertile PCOS patients Conclusions:The patients with PCOS are under oxidative stress and this oxidative stress seems to be the highest in patients with IR and with infertility. Despite the prominent increase in the oxidative stress, there was a variation in the antioxidant response.

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Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium

Cited by 49 publications

References 55 publications

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Cytoprotective effects of dietary flavonoids against cadmium‐induced toxicity

Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome

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