Oxidative stress–associated hypertension in surgically induced brain injury patients: Effects of β-blocker and angiotensin-converting enzyme inhibitor

Velayutham, Parthiban; Adhikary, Sanjib Das; Babu, Srinivasa; Rajshekhar, Vedantam; Korula, Grace; Ramachandran, Anup

doi:10.1016/j.jss.2012.09.005

Cited by 18 publications

(16 citation statements)

References 37 publications

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“…Some radicals were known to be involved in the occurrence of hypertension (Velayutham et al . ). Matsumoto et al .…”

Section: Discussionmentioning

confidence: 97%

“…Interestingly, Val-Trp also showed antioxidant activities, such as superoxide and DPPH radical scavenging activity and ferric-reducing antioxidant power. Some radicals were known to be involved in the occurrence of hypertension (Velayutham et al 2012). Matsumoto et al (2004) demonstrated the synergic effect of antioxidant and sardine protein hydrolysate on blood pressure.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation and Identification of Potent Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Dwarf Gulper Shark (C entrophorus atromarginatus )

Ikeda

Ichino

Kiguchiya

et al. 2014

Journal of Food Processing and Preservation

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Dwarf gulper shark (Centrophorus atromarginatus) lives in tropical to temperate waters and has a plenty of squalene in the liver. On the other hand, its muscle is an unused resource in Japan because of high urea content. Here, we tried to find the new procedure for the preparation of angiotensin‐I converting enzyme (ACE) inhibitory hydrolysate from this shark. Nine hydrolysates were prepared using food‐processing proteases. Among them, three hydrolysates produced by Protease P, Papain and Thermoase showed the potent ACE inhibitory activity (The IC50 values: 172.2, 144.2 and 84.2 μg/mL, respectively). From Thermoase hydrolysate, Val‐Trp was found as the most potent inhibitory peptide (IC50 value: 3.3 μg/mL). The mechanism of inhibition of Val‐Trp for ACE was competitive. Val‐Trp also exhibited antioxidant activities, suggesting the efficacy as bifunctional peptide against hypertension. This study showed the new possibility of the usage of dwarf gulper shark as material for healthy food. Practical Applications This study introduces processing techniques for potent ACE inhibitory hydrolysate from dwarf gulper shark muscle by using food‐processing proteases. This hydrolysate shows low bitterness, which is suitable for the usage as functional food. The strongest ACE inhibitory peptide in this hydrolysate also possessed antioxidant activity, suggesting that the hydrolysate would be useful for hypertension acting as bifunctional (ACE inhibitory and antioxidative). Results of this study will contribute to utilize dwarf gulper shark muscle, a nonutilized resource in Japan.

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“…Some radicals were known to be involved in the occurrence of hypertension (Velayutham et al . ). Matsumoto et al .…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Evaluation and Identification of Potent Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Dwarf Gulper Shark (C entrophorus atromarginatus )

Ikeda

Ichino

Kiguchiya

et al. 2014

Journal of Food Processing and Preservation

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“…According to these authors, lisinopril may be considered as a potential pharmacological agent for the management of hypertension-induced vascular dementia. Velayutham et al have conducted a study to investigate the effect of pretreatment with lisinopril on postoperative hypertension in patients undergoing neurosurgery for supratentorial brain tumors and the role of oxidative stress in this process [24] and found that perioperative hemodynamic changes were highly associated with oxidative stress parameters in all three groups. It was observed that lisinopril significantly decreased MDA levels, protein carbonyl content and nitrate during surgical intervention (p < 0.05), an effect which has lasted after the operation.…”

Section: Plasma No Concentrationmentioning

confidence: 99%

Effects of lisinopril on oxidative stress in brain tissues of rats with L-NAME induced hypertension

Kırbaş¹,

Kutluhan²,

Kırbaş³

et al. 2013

Turk J Bioch

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Objective: Arterial hypertension is often associated with pathologies related with oxidative stress. Angiotensin converting enzyme (ACE) inhibitors have been used as a safe and effective treatment of hypertension and coronary heart disease. However, the significance of ACE inhibitor usage in hypertension-induced cerebrovascular and neurodegenerative diseases is still unknown. In this study, we aimed to investigate the effects of lisinopril, an ACE inhibitor, on oxidative stress and antioxidant enzyme activities in brain tissues of rats with L-NAME (N ω -Nitro-L-Arginine Methyl Ester hydrochloride) induced hypertension. Methods: Thirty-two Sprague-Dawley rats were divided into four groups: Control, L-NAME, L-NAME plus lisinopril, and only lisinopril. Hypertension was induced by oral administration of the L-NAME (75 mg/kg/day) in drinking water for 6 weeks. Rats were treated with Lisinopril (10 mg/kg/day) for six weeks. Systolic blood pressures were measured at the first, third and sixth weeks by using tail cuff method. Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) activity were measured from the brain tissue. Nitric oxide (NO) levels were measured from plasma. Results: Our results showed that L-NAME leads to an increase in systolic blood pressure of animals. The antihypertensive effect of lisinopril was observed. MDA level was significantly increased, and antioxidant enzymes activities were decreased in L-NAME given group (p<0.05). However, there was no statistically significant differences between the lisinopril given and other groups according to antioxidant enzymes activities (p>0.05). Conclusion: In our study, hypertension led to oxidative damage in brain tissues. Although lisinopril prevents the hypertension induced oxidative damage, direct antioxidant effect was not observed. Further studies are needed in order to gain certainty effect of lisinopril in brain tissue.

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“…For instance, Velayutham et al examined the relationship of lisinopril treatment with MDA parameter. 21 They reported that MDA level was significantly lowered in hypertensive patients with supratentorial brain tumors after receiving half strength of lisinopril (5 mg). Lisinopril, along with its blood lowering effects can influence on the other actions.…”

mentioning

confidence: 99%

Relationship of lisinopril with kallikrein-kinin system in hypertensive patients in Erbil city, Iraq

Hamad¹,

Ibrahim

2018

ZJMS

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in the pathogenesis of hypertension through interaction with the elements of the renin-angiotensin system. This study aimed to examine the effects of lisinopril on mean arterial pressure and biosubstances of Kallikrein-kinin-system (bradykinin), endothelial dysfunction (nitric oxide), and oxidative stress (malondialdehyde). Methods: A clinical trial was conducted in Erbil city from December 1 st , 2015 to August 10 th , 2016. The study included 65 patients with essential hypertension and 25 apparently healthy subjects; their ages were in between 18 and 55 years. The patients were receiving 10 mg lisinopril orally per day for six weeks as a starting dose. Results: At hypertension diagnosis, patients were with lower bradykinin and nitric oxide levels when compared with apparently healthy subjects; however, malondialdehyde level showed no significant difference when compared with of healthy subjects. After six weeks patients treatment, comparing bradykinin, nitric oxide, and malondialdehyde mean levels with their baselines, showed that significantly increased in bradykinin and nitric oxide (P <0.01) and significantly decreased in malondialdehyde (P <0.01). On the other hand, the differences between after treatment and healthy subjects had no significant difference, except bradykinin. Eventually, during treatment, the mean arterial pressure was significantly lowered. Conclusion: in addition to the significant lowering of blood pressure, lisinopril 10 mg daily for six weeks can significantly elevate kallikrein-kinin system and endothelial dysfunction markers, and significantly lowered in oxidative stress marker in hypertensive Kurd patients in Erbil city.

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Oxidative stress–associated hypertension in surgically induced brain injury patients: Effects of β-blocker and angiotensin-converting enzyme inhibitor

Cited by 18 publications

References 37 publications

Evaluation and Identification of Potent Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Dwarf Gulper Shark (C entrophorus atromarginatus )

Evaluation and Identification of Potent Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Dwarf Gulper Shark (C entrophorus atromarginatus )

Effects of lisinopril on oxidative stress in brain tissues of rats with L-NAME induced hypertension

Relationship of lisinopril with kallikrein-kinin system in hypertensive patients in Erbil city, Iraq

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