Evaluation and Identification of Potent Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Dwarf Gulper Shark (<i>C</i>
                        <i>entrophorus atromarginatus</i>
)

Ikeda, Asami; Ichino, Hayato; Kiguchiya, Saori; Chigwechokha, Petros Kingstone; Komatsu, Masaharu; Shiozaki, Kazuhiro

doi:10.1111/jfpp.12210

Cited by 8 publications

(4 citation statements)

References 30 publications

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“…The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, superoxide radical scavenging assay, and ferric-reducing antioxidant power assay were measured according to Ikeda et al . [ 12 ]. Briefly, 25 μL CK was used as a test sample in 1 mL of reaction mix in all assays.…”

Section: Methodsmentioning

confidence: 99%

The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice

et al. 2016

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Kurozu is a traditional Japanese rice vinegar. During fermentation and aging of the Kurozu liquid in an earthenware jar over 1 year, a solid residue called Kurozu Moromi is produced. In the present study, we evaluated whether concentrated Kurozu or Kurozu Moromi could ameliorate cognitive dysfunction in the senescence-accelerated P8 mouse. Senescence-accelerated P8 mice were fed 0.25% (w/w) concentrated Kurozu or 0.5% (w/w) Kurozu Moromi for 4 or 25 weeks. Kurozu suppressed cognitive dysfunction and amyloid accumulation in the brain, while Kurozu Moromi showed a tendency to ameliorate cognitive dysfunction, but the effect was not significant. We hypothesize that concentrated Kurozu has an antioxidant effect; however, the level of lipid peroxidation in the brain did not differ in senescence-accelerated P8 mice. DNA microarray analysis indicated that concentrated Kurozu increased HSPA1A mRNA expression, a protein that prevents protein misfolding and aggregation. The increase in HSPA1A expression by Kurozu was confirmed using quantitative real-time PCR and immunoblotting methods. The suppression of amyloid accumulation by concentrated Kurozu may be associated with HSPA1A induction. However, concentrated Kurozu could not increase HSPA1A expression in mouse primary neurons, suggesting it may not directly affect neurons.

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Section: Methodsmentioning

confidence: 99%

The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice

et al. 2016

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“…The ACE inhibitory activity of marine-derived bioactive peptides appears to be higher than that of peptides from terrestrial sources [44]. Marine-derived ACE inhibitory peptides share a short aminoacidic sequence characterized by low molecular weights and hydrophobic residues [107] that confer increased anti ACE activities [37].…”

Section: Marine Cardiovascular Active Peptides Targeting the Ace Systmentioning

confidence: 99%

Cardiovascular Active Peptides of Marine Origin with ACE Inhibitory Activities: Potential Role as Anti-Hypertensive Drugs and in Prevention of SARS-CoV-2 Infection

Festa

Sansone

Brunet

et al. 2020

IJMS

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Growing interest in hypertension—one of the main factors characterizing the cardiometabolic syndrome (CMS)—and anti-hypertensive drugs raised from the emergence of a new coronavirus, SARS-CoV-2, responsible for the COVID19 pandemic. The virus SARS-CoV-2 employs the Angiotensin-converting enzyme 2 (ACE2), a component of the RAAS (Renin-Angiotensin-Aldosterone System) system, as a receptor for entry into the cells. Several classes of synthetic drugs are available for hypertension, rarely associated with severe or mild adverse effects. New natural compounds, such as peptides, might be useful to treat some hypertensive patients. The main feature of ACE inhibitory peptides is the location of the hydrophobic residue, usually Proline, at the C-terminus. Some already known bioactive peptides derived from marine resources have potential ACE inhibitory activity and can be considered therapeutic agents to treat hypertension. Peptides isolated from marine vertebrates, invertebrates, seaweeds, or sea microorganisms displayed important biological activities to treat hypertensive patients. Here, we reviewed the anti-hypertensive activities of bioactive molecules isolated/extracted from marine organisms and discussed the associated molecular mechanisms involved. We also examined ACE2 modulation in sight of SARS2-Cov infection prevention.

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“…The ACE inhibitory activity of marine-derived bioactive peptides were higher compared to ACE inhibitory peptide-derived from terrestrial food source (i.e., milk, chicken muscle and bovine) [23,24]. Marine-derived ACE inhibitory peptides are generally short chain peptides [18,25,26,27]. It was reported that amino acid residues with bulky side chain as well as hydrophobic side chains were more active for dipeptides [28].…”

Section: Marine-derived Cardio Protective Peptidesmentioning

confidence: 99%

Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non-Communicable Diseases

Pangestuti

Kim

2017

Marine Drugs

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Non-communicable diseases (NCD) are the leading cause of death and disability worldwide. The four main leading causes of NCD are cardiovascular diseases, cancers, respiratory diseases and diabetes. Recognizing the devastating impact of NCD, novel prevention and treatment strategies are extensively sought. Marine organisms are considered as an important source of bioactive peptides that can exert biological functions to prevent and treatment of NCD. Recent pharmacological investigations reported cardio protective, anticancer, antioxidative, anti-diabetic, and anti-obesity effects of marine-derived bioactive peptides. Moreover, there is available evidence supporting the utilization of marine organisms and its bioactive peptides to alleviate NCD. Marine-derived bioactive peptides are alternative sources for synthetic ingredients that can contribute to a consumer’s well-being, as a part of nutraceuticals and functional foods. This contribution focus on the bioactive peptides derived from marine organisms and elaborates its possible prevention and therapeutic roles in NCD.

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Evaluation and Identification of Potent Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Dwarf Gulper Shark (C entrophorus atromarginatus )

Cited by 8 publications

References 30 publications

The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice

The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice

Cardiovascular Active Peptides of Marine Origin with ACE Inhibitory Activities: Potential Role as Anti-Hypertensive Drugs and in Prevention of SARS-CoV-2 Infection

Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non-Communicable Diseases

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