Oxidative Stress as a Therapeutic Target of Cardiac Remodeling

Martins, Daniel Freitas Freire; Garcia, Leonardo Rufino; Queiróz, Diego Aparecido Rios; Lazzarin, Taline; Tonon, Carolina Rodrigues; Balin, Paola da Silva; Polegato, Bertha Furlan; Paiva, Sérgio Alberto Rupp de; Azevedo, Paula Schmidt; Minicucci, Marcos F.; Zornoff, Leonardo Antônio Mamede

doi:10.3390/antiox11122371

Cited by 13 publications

(14 citation statements)

References 73 publications

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“…The extracellular matrix plays a role in mediating mechanical connections between cardiomyocytes, fibroblasts and blood vessels within the myocardium, transmitting extracellular mechanical signals, supporting cell migration and providing structural and functional integrity to the heart [5]. Excessive deposition of extracellular matrix, including collagen types I and III, is characteristic of cardiac fibrosis in patients with hypertension.…”

Section: International Journal Of Scientific Advancesmentioning

confidence: 99%

Effect of Combination from Purple Sweet Potato (Ipomoea batatas L.) Ethanolic Extract and Ramipril Administration on Myocardial Platelet Derived Growth Factor an Expression and Myocardial Collagen Deposition in Hypertensive Rat Models

Bhuana,

Wiryawan,

Antara

2023

International Journal of Scientific Advances

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Objective: To determine the effect of administration of combination of purple sweet potato (Ipomoea Batatas L.) ethanolic extract and ramipril in a rat model of hypertension. Methods: This is an experimental study with a post-test only control group design and is a collaborative study of the effect of giving a combination of ethanol extract of purple sweet potato tuber (Ipomoea batatas L.) and ramipril in a rat model of hypertension. Thirty male Wistar rats were given 2 mL/day of 4% NaCl diet to induce hypertension. The rats were divided into 3 treatment groups, consisting of NaCl 4% 2 mL/day+combination therapy with purple sweet potato tuber ethanol extract 400 mg/kgBW/day and ramipril 1 mg/day, NaCl 4% 2 mL/day+purple sweet potato tuber ethanol extract 400 mg/kgBW/day and NaCl 4% 2 mL/day+ramipril 1 mg/day. At week 5, rat was executed to examine myocardial PDGF-A expression and measure myocardial collagen deposition. All the obtained data were analyzed statistically. Results: Administration of ethanolic extract of purple sweet potato 400mg/kgBW/day + ramipril 1mg/day significantly reduced myocardial PDGF-A expression compared to ethanolic extract of purple sweet potato alone (mean difference 14.17 pg/mLCI95% 2.36 – 25.98, P value = 0.016) or ramipril 1mg/day (mean difference 25.58 pg/mL; CI95% 17.07 – 40.09l, P value < 0.001). Administration of ethanolic extract of purple sweet potato 400mg/kgBW/day + ramipril 1mg/day significantly reduced myocardial collagen deposition when compared to administration of purple sweet potato alone (mean difference: 3.30%; CI 95% 1.97 – 4.64; P value <0.001). Administration of ethanolic extract of purple sweet potato combined with ramipril has higher potential effect in reducing myocardial PDGF-A expression and myocardial collagen deposition, compared to single therapy. Conclusion: Administration of ethanolic extract of purple sweet potato combined with ramipril was able to provide the best reduction in myocardial PDGF-A expression and myocardial collagen deposition.

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Section: International Journal Of Scientific Advancesmentioning

confidence: 99%

Effect of Combination from Purple Sweet Potato (Ipomoea batatas L.) Ethanolic Extract and Ramipril Administration on Myocardial Platelet Derived Growth Factor an Expression and Myocardial Collagen Deposition in Hypertensive Rat Models

Bhuana,

Wiryawan,

Antara

2023

International Journal of Scientific Advances

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“…Tables 1 and 2 show the datasets of these molecules identified in PO and MO groups, respectively. Metabolomic analysis identified some metabolites that are precursors of molecules mostly related to the biological processes involved in modulating inflammation, oxidative stress, and extracellular matrix, which are important regulators of cardiac remodeling [4,[29][30][31][32][33]. These metabolites identified in the PO and MO groups may have beneficial effects on cardiac remodeling and prevent heart failure development and progression.…”

Section: High-resolution Mass Spectrometrymentioning

confidence: 99%

Effects of Pera Orange Juice and Moro Orange Juice in Healthy Rats: A Metabolomic Approach

et al. 2023

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Cardiovascular disease is a leading cause of death worldwide. Heart failure is a cardiovascular disease with high prevalence, morbidity, and mortality. Several natural compounds have been studied for attenuating pathological cardiac remodeling. Orange juice has been associated with cardiovascular disease prevention by attenuating oxidative stress. However, most studies have evaluated isolated phytochemicals rather than whole orange juice and usually under pathological conditions. In this study, we evaluated plasma metabolomics in healthy rats receiving Pera or Moro orange juice to identify possible metabolic pathways and their effects on the heart. Methods: Sixty male Wistar rats were allocated into 3 groups: control (C), Pera orange juice (PO), and Moro orange juice (MO). PO and MO groups received Pera orange juice or Moro orange juice, respectively, and C received water with maltodextrin (100 g/L). Echocardiogram and euthanasia were performed after 4 weeks. Plasma metabolomic analysis was performed by high-resolution mass spectrometry. Type I collagen was evaluated in picrosirius red-stained slides and matrix metalloproteinase (MMP)-2 activity by zymography. MMP-9, tissue inhibitor of metalloproteinase (TIMP)-2, TIMP-4, type I collagen, and TNF-α protein expression were evaluated by Western blotting. Results: We differentially identified three metabolites in PO (N-docosahexaenoyl-phenylalanine, diglyceride, and phosphatidylethanolamine) and six in MO (N-formylmaleamic acid, N2-acetyl-L-ornithine, casegravol isovalerate, abscisic alcohol 11-glucoside, cyclic phosphatidic acid, and torvoside C), compared to controls, which are recognized for their possible roles in cardiac remodeling, such as extracellular matrix regulation, inflammation, oxidative stress, and membrane integrity. Cardiac function, collagen level, MMP-2 activity, and MMP-9, TIMP-2, TIMP-4, type I collagen, and TNF-α protein expression did not differ between groups. Conclusion: Ingestion of Pera and Moro orange juice induces changes in plasma metabolites related to the regulation of extracellular matrix, inflammation, oxidative stress, and membrane integrity in healthy rats. Moro orange juice induces a larger number of differentially expressed metabolites than Pera orange juice. Alterations in plasma metabolomics induced by both orange juice are not associated with modifications in cardiac extracellular matrix components. Our results allow us to postulate that orange juice may have beneficial effects on pathological cardiac remodeling.

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“…It is also a significant factor in determining morbidity and mortality rates. 6 Ventricular remodelling causes changes to the structure and function of the heart, resulting in ventricular hypertrophy, enlargement of the ventricular chambers, and progressive cardiac decompensation. These changes contribute to the progression and deterioration of heart failure and even death.…”

Section: Introductionmentioning

confidence: 99%

“…Ventricular remodelling is the primary physiological process that leads to ventricular dysfunction and heart failure. It is also a significant factor in determining morbidity and mortality rates 6 . Ventricular remodelling causes changes to the structure and function of the heart, resulting in ventricular hypertrophy, enlargement of the ventricular chambers, and progressive cardiac decompensation.…”

Section: Introductionmentioning

confidence: 99%

Effect of levosimendan on ventricular remodelling in patients with left ventricular systolic dysfunction: a meta‐analysis

Wang,

Zhao,

Wang

et al. 2024

ESC Heart Failure

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Heart failure is the final stage of several cardiovascular diseases, and the key to effectively treating heart failure is to reverse or delay ventricular remodelling. Levosimendan is a novel inotropic and vasodilator agent used in heart failure, whereas the impact of levosimendan on ventricular remodelling is still unclear. This study aims to investigate the impact of levosimendan on ventricular remodelling in patients with left ventricular systolic dysfunction. Electronic databases were searched to identify eligible studies. A total of 66 randomized controlled trials involving 7968 patients were included. Meta‐analysis results showed that levosimendan increased left ventricular ejection fraction [mean difference (MD) = 3.62, 95% confidence interval (CI) (2.88, 4.35), P < 0.00001] and stroke volume [MD = 6.59, 95% CI (3.22, 9.96), P = 0.0001] and significantly reduced left ventricular end‐systolic volume [standard mean difference (SMD) = −0.52, 95% CI (−0.67, −0.37), P < 0.00001], left ventricular end‐diastolic volume index [SMD = −1.24, 95% CI (−1.61, −0.86), P < 0.00001], and left ventricular end‐systolic volume index [SMD = −1.06, 95% CI (−1.43, −0.70), P < 0.00001]. In terms of biomarkers, levosimendan significantly reduced the level of brain natriuretic peptide [SMD = −1.08, 95% CI (−1.60, −0.56), P < 0.0001], N‐terminal pro‐brain natriuretic peptide [SMD = −0.99, 95% CI (−1.41, −0.56), P < 0.00001], and interleukin‐6 [SMD = −0.61, 95% CI (−0.86, −0.35), P < 0.00001]. Meanwhile, levosimendan may increase the incidence of hypotension [risk ratio (RR) = 1.24, 95% CI (1.12, 1.39), P < 0.0001], hypokalaemia [RR = 1.57, 95% CI (1.08, 2.28), P = 0.02], headache [RR = 1.89, 95% CI (1.50, 2.39), P < 0.00001], atrial fibrillation [RR = 1.31, 95% CI (1.12, 1.52), P = 0.0005], and premature ventricular complexes [RR = 1.86, 95% CI (1.27, 2.72), P = 0.001]. In addition, levosimendan reduced all‐cause mortality [RR = 0.83, 95% CI (0.74, 0.94), P = 0.002]. In conclusion, our study found that levosimendan might reverse ventricular remodelling when applied in patients with left ventricular systolic dysfunction, especially in patients undergoing cardiac surgery, decompensated heart failure, and septic shock.

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Oxidative Stress as a Therapeutic Target of Cardiac Remodeling

Cited by 13 publications

References 73 publications

Effect of Combination from Purple Sweet Potato (Ipomoea batatas L.) Ethanolic Extract and Ramipril Administration on Myocardial Platelet Derived Growth Factor an Expression and Myocardial Collagen Deposition in Hypertensive Rat Models

Effect of Combination from Purple Sweet Potato (Ipomoea batatas L.) Ethanolic Extract and Ramipril Administration on Myocardial Platelet Derived Growth Factor an Expression and Myocardial Collagen Deposition in Hypertensive Rat Models

Effects of Pera Orange Juice and Moro Orange Juice in Healthy Rats: A Metabolomic Approach

Effect of levosimendan on ventricular remodelling in patients with left ventricular systolic dysfunction: a meta‐analysis

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