Oxidative Stress and Preeclampsia-Associated Prothrombotic State

Han, Choong‐Hee; Huang, Pengzhu; Lyu, Meilu; Dong, Jing‐fei

doi:10.3390/antiox9111139

Cited by 23 publications

(22 citation statements)

References 169 publications

(181 reference statements)

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“…The pathogenic mechanisms of PIH and pre-eclampsia are not clear, but have been reviewed widely, and included innate immunity, [ 33 ] bioactive factors (such as inflammatory cytokines, angiogenetic factors, growth factors, etc. ), [ 34 , 35 ] oxidative stress, [ 36 ] placental vascular maladaptation, [ 37 ] and endothelial dysfunction. [ 38 , 39 ] Among these, endothelial dysfunction is the most likely underlying mechanism, [ 39 ] which causes imbalance between an endothelial-derived vasodilator (such as nitric oxide and prostacyclin) and vasoconstrictors (such as endothelin-1, thromboxane A2), leading to the promotion of vasoconstriction, hypertension, and pre-eclampsia.…”

Section: Discussionmentioning

confidence: 99%

Predicting factors of adverse pregnancy outcomes in Thai patients with systemic lupus erythematosus

et al. 2021

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Studies on predicting factors for adverse pregnancy outcomes (APOs) in Thai patients with systemic lupus erythematosus (SLE) are limited. This retrospective observation study determined APOs and their predictors in Thai patients with SLE. Medical records of pregnant SLE patients in a lupus cohort, seen from January 1993 to June 2017, were reviewed. Ninety pregnancies (1 twin pregnancy) from 77 patients were identified. The mean age at conception was 26.94 ± 4.80 years. At conception, 33 patients (36.67%) had active disease, 23 (25.56%) hypertension, 20 (22.22%) renal involvement, and 6 of 43 (13.95%) positive anti-cardiolipin antibodies or lupus anti-coagulants, and 37 (41.11%) received hydroxychloroquine. Nineteen patients (21.11%) had pregnancy loss. Of 71 successful pregnancies, 28 (31.11%) infants were full-term, 42 (46.67%) pre-term and 1 (11.11%) post-term; 19 (26.39%) were small for gestational age (SGA), and 38 (52.58%) had low birth weight (LBW). Maternal complications occurred in 21 (23.33%) pregnancies [10 (11.11%) premature rupture of membrane (PROM), 8 (8.89%) pregnancy induced hypertension (PIH), 4 (4.44%) oligohydramnios, 2 (2.22%) post-partum hemorrhage, and 1 (1.11%) eclampsia]. Patients aged ≥ 25 years at pregnancy and those ever having renal involvement had predicted pregnancy loss with adjusted odds ratio (AOR) [95% CI] of 4.15 [1.10–15.72], P = .036 and 9.21 [1.03–82.51], P = .047, respectively. Renal involvement predicted prematurity (6.02 [1.77–20.52, P = .004), SGA (4.46 [1.44–13.78], P = .009), and LBW in infants (10.01 [3.07–32.62], P < .001). Prednisolone (>10 mg/day) and immunosuppressive drugs used at conception protected against prematurity (0.11 [0.02–0.85], P = .034). Flares and hematologic involvement predicted PROM (8.45 [1.58–45.30], P = .013) and PIH (9.24 [1.70–50.24], P = .010), respectively. Cutaneous vasculitis (33.87 [1.05–1,094.65], P = .047), and renal (31.89 [6.66–152.69], P < .001), mucocutaneous (9.17 [1.83–45.90], P = .007) and hematologic involvement (128.00 [4.60–3,564.46], P = .004) during pregnancy predicted flare; while prednisolone (>10 mg/day) and immunosuppressive drug use at conception reduced that risk (0.08 [0.01–0.68, P = .021). APOs remain a problem in Thai pregnant SLE patients. Renal involvement and SLE flares were associated with the risk of APOs.

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Section: Discussionmentioning

confidence: 99%

Predicting factors of adverse pregnancy outcomes in Thai patients with systemic lupus erythematosus

et al. 2021

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“…Previous studies have shown that hypertensive disorders of pregnancy are associated with increased systemic inflammation, as depicted by the platelets in gravidas. [ 16 ] However, it is necessary to further explore the association between GDM and hematological parameters. We conducted a longitudinal case control study to test the following hypotheses:…”

Section: Introductionmentioning

confidence: 99%

Distribution of complete blood count constituents in gestational diabetes mellitus

Zhang¹,

Zhang²,

Zhao³

et al. 2021

Medicine

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Background (Trial Design): The incidence rate of gestational diabetes is high. In the long run, it harms the health of both the mother and child. In order to understand the distribution of hematological cells with gestational diabetes mellitus (GDM), a longitudinal cohort study was conducted from 2012 to 2018. Methods: A longitudinal case control study of 1860 pregnant women was conducted between 2012 and 2018. Data of hematological parameters at 11 time points of gestational stage were obtained from a laboratory database. Repeated measures analysis and independent t-test were used to analyze the effect of the hematological parameters on GDM. Results: The trend of blood cells fluctuated with gestational age in normal controls but was more remarkable in GDM. Compared with the controls, blood neutrophils, lymphocytes, and monocytes augmented in the second trimester but decreased in the third trimester; platelet (PLT) and thrombocytocrit increased throughout the three trimesters, and red blood cell (RBC) was abundant in the last 2 trimesters in GDM. Conclusions: Peripheral blood leukocytes, platelets, and erythrocytes were significantly different during gestation between GDM and normal controls. Inflammation may also be involved in GMD.

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“…Preeclampsia (PE) is a common complication during pregnancy that affects 5-8% of pregnant women (1,2). PE is associated with a variety of short-term and long-term complications in mothers and infants, such as placental abruption, cardiovascular disease, renal disease, metabolic disorders, fetal growth restriction (FGR), and preterm birth (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

The Association Between ABO Blood Group and Preeclampsia: A Systematic Review and Meta-Analysis

Wang

et al. 2021

Front. Cardiovasc. Med.

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Objective: This meta-analysis comprehensively evaluated the association between ABO blood group and the risk of preeclampsia (PE).Design: Systematic review and meta-analysis.Data sources: PubMed, Web of Science, and ScienceDirect databases from their inception to September 23, 2020.Methods: Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were obtained through random-effects and fixed-effects models according to heterogeneity. Meta-regression analysis was applied to explore the source of heterogeneity. We conducted a subgroup analysis by the publication year, study design, state, and Newcastle-Ottawa Scale (NOS) score. In addition, we calculated the rate of each ABO blood group in PE by total pooled effects.Results: A total of 12 articles with 714,153 patients were included in our analysis. Compared with people without PE (control group), the O blood group presented a lower risk of PE (OR 0.95, 95% CI 0.93–0.97). The AB (OR 1.46, 95% CI 1.12–1.91) blood group presented a higher risk. However, the total pooled OR and 95% CI for the A (OR 1.02, 95% CI 0.90–1.16) and B (OR 1.02, 95% CI 0.98–1.05) blood groups were not significant. The funnel plot and linear regression equation showed that there was no publication bias for the O, A, or B blood groups (all P > 0.05). However, the funnel plot and linear regression equation for the AB blood group were obviously asymmetric (P < 0.05), and the publication bias persisted even after the trim-and-fill method was applied (P < 0.05). Multivariable meta-regression analysis did not find a specific source of heterogeneity. The A blood group showed an association with early-onset PE (OR 0.53, 95% CI 0.33–0.83), and the other blood groups showed no significant differences. In PE, the rates of the O, A, B, and AB blood groups decreased gradually (0.39, 0.33, 0.19, 0.07).Conclusion: These findings suggest that pregnant women with AB blood group are more likely to develop PE, and more attention should be paid to AB blood group whose blood pressure is high but not sufficient to diagnose PE.Systematic Review Registration: Prospero CRD42021227930.

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Oxidative Stress and Preeclampsia-Associated Prothrombotic State

Cited by 23 publications

References 169 publications

Predicting factors of adverse pregnancy outcomes in Thai patients with systemic lupus erythematosus

Predicting factors of adverse pregnancy outcomes in Thai patients with systemic lupus erythematosus

Distribution of complete blood count constituents in gestational diabetes mellitus

The Association Between ABO Blood Group and Preeclampsia: A Systematic Review and Meta-Analysis

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