Oxidative stress and myocardial dysfunction in young rabbits after short term anabolic steroids administration

Germanakis, Ioannis; Tsarouhas, Konstantinos; Fragkiadaki, Persefoni; Tsitsimpikou, Christina; Goutzourelas, Nikolaos; Champsas, Maria Christakis; Stagos, Demetrios; Rentoukas, Elias; Tsatsakis, Aristidis

doi:10.1016/j.fct.2013.03.018

Cited by 30 publications

(24 citation statements)

References 30 publications

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“…Prolonged administration of steroids may cause dysfunction of the mitochondrial respiratory chain complex and mono-oxygenase leading to increased generation of ROS. 19 In the work of Germanakis et al 20 there was a decrease in antioxidant enzymes such as catalase and increase in thiobarbituric acid reactive substances. For Chaves and Fortunato et al 21 the use of AAS abolished the exercise-induced protection found that there was a decrease in cardiac cardioprotection through the blockade of the antioxidant enzymes superoxide dismutase and glutathione peroxidase in the anabolic groups, and in the trained group without anabolic agent , this fact did not occur.…”

Section: Discussionmentioning

confidence: 98%

Nandrolone Decanoate Is Prooxidant in the Myocardium of Exercised or Sedentary Rats

Pinheiro

Maia

Lima

et al. 2020

Rev Bras Med Esporte

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Introduction: Nandrolone decanoate is a synthetic testosterone analogue considered one of the most widely used anabolic androgenic steroids (AAS) among adolescents and athletes. Chronic ingestion of AAS increases the incidence of cardiovascular abnormalities in athletes, but the mechanism that causes these changes remains unknown. Objectives: The purpose of this study is to verify the possible effects of the use of anabolic androgenic steroids (AAS) on the morphology and oxidative metabolism of the heart in exercised and sedentary rats. Methods: This is a comparative prospective level II study. Twenty-four Wistar rats were distributed in groups that performed voluntary (TG) and sedentary (SG) running exercises, and used AAS: the Anabolic Training Group (ATG), and the Anabolic Sedentary Group (ASG). During the three months of the running protocol, the animals received an intramuscular injection of 5 mg/kg b.p. of AAS. After the training period, the rats were euthanized and the hearts were removed for evaluation of lipid peroxidation and antioxidant capacity, and for morphometric analysis. Results: The anabolic groups, ASG (0.3072 ± 0.0531) and ATG (0.2732 ± 0.0413), presented higher lipid peroxidation when compared to the non-anabolic groups SG (0.1705 ± 0.0224) and TG (0.1785 ± 0.0340). Conclusion: There was no change in total antioxidant capacity or in the thickness of the interventricular septum and left ventricular wall. Thus, the use of anabolic androgenic steroids did not cause morphological changes in the myocardium. However it did alter the oxidative metabolism. It was also verified that aerobic exercise had no protective effect against lipid peroxidation in the myocardium caused by the use of AAS. Level of evidence II; Prospective comparative study.

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Section: Discussionmentioning

confidence: 98%

Nandrolone Decanoate Is Prooxidant in the Myocardium of Exercised or Sedentary Rats

Pinheiro

Maia

Lima

et al. 2020

Rev Bras Med Esporte

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“…Some AAS are directly involved in oxidative stress appearance. For example, repeated low level administration of turinabol and methanabol had no significant effects on oxidative stress markers, while the high dose created oxidative stress and myocardial dysfunction in young rabbits [14]. Authors emphasize high hazard from high doses of these AAS, especially in young human subjects.…”

Section: Skeletal Muscle Force Production and Hypertrophymentioning

confidence: 95%

Oxidative Stress in Muscle Growth and Adaptation to Physical Exercise

Yurkevych¹

2015

jpnu

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Abstract. In a few last decades oxidative stress detected in a variety of physiological processes where reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a central role. They are directly involved in oxidation of proteins, lipids and nucleic acids. In certain concentrations they are necessary for cell division, proliferation and apoptosis. Contractile muscle tissue at aerobic conditions form high ROS flow that may modulate a variety of cell functions, for example proliferation. However, slight increase in ROS level provide hormetic effect which may participate in adaptation to heavy weight training resulted in hypertrophy and proliferation of skeletal muscle fibers. This review will discuss ROS types, sites of generation, strategies to increase force production and achieve skeletal muscle hypertrophy.

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“…Similarly, turinabol treatment increases TBARS levels by 46% with slight increases in CAT activity in rabbit plasma. Methandienone treatment reduces total antioxidant capacity by 46% (67). Interestingly, only high doses of the anabolic androgenic steroids were able to provoke these effects.…”

Section: Other Mechanisms: Testosterone and Ros Generation/oxidative mentioning

confidence: 96%

Reactive oxygen species: players in the cardiovascular effects of testosterone

Tostes

Carneiro

Carvalho

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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Tostes RC, Carneiro FS, Carvalho MH, Reckelhoff JF. Reactive oxygen species: players in the cardiovascular effects of testosterone. Am J Physiol Regul Integr Comp Physiol 310: R1-R14, 2016. First published November 4, 2015 doi:10.1152/ajpregu.00392.2014.-Androgens are essential for the development and maintenance of male reproductive tissues and sexual function and for overall health and well being. Testosterone, the predominant and most important androgen, not only affects the male reproductive system, but also influences the activity of many other organs. In the cardiovascular system, the actions of testosterone are still controversial, its effects ranging from protective to deleterious. While early studies showed that testosterone replacement therapy exerted beneficial effects on cardiovascular disease, some recent safety studies point to a positive association between endogenous and supraphysiological levels of androgens/testosterone and cardiovascular disease risk. Among the possible mechanisms involved in the actions of testosterone on the cardiovascular system, indirect actions (changes in the lipid profile, insulin sensitivity, and hemostatic mechanisms, modulation of the sympathetic nervous system and renin-angiotensin-aldosterone system), as well as direct actions (modulatory effects on proinflammatory enzymes, on the generation of reactive oxygen species, nitric oxide bioavailability, and on vasoconstrictor signaling pathways) have been reported. This mini-review focuses on evidence indicating that testosterone has prooxidative actions that may contribute to its deleterious actions in the cardiovascular system. The controversial effects of testosterone on ROS generation and oxidant status, both prooxidant and antioxidant, in the cardiovascular system and in cells and tissues of other systems are reviewed. cardiovascular; prooxidant; antioxidant TESTOSTERONE 1 IS THE PREDOMINANT and most important androgen, playing a major role in the development of male reproductive tissues (130,135). "Androgen" is a broad term for any natural or synthetic compound that primarily influences the growth and development of the male reproductive system, including the activity of the accessory male sex organs and development of male secondary sex characteristics (21, 135). Androgens are also essential for health and well being, and their beneficial and stimulant effects have been known for a long time, since the seminal studies from Brown-Séquard in the nineteenth century 2 (22, 135): "ь ь ь in the seminal fluid, as secreted by the testicles, a substance or several substances exist which, entering the blood by resorption, have a most essential use in giving strength to the nervous system and to other parts ь ь ь ."Other androgens include androstenedione, 5␣-dihydrotestosterone (DHT), which is produced from testosterone by the enzyme 5␣-reductase, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEA-S), and synthetic androgens in their many steroid ester variations (e.g., testosterone cypionate, decanoate, undecanoate, enant...

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Oxidative stress and myocardial dysfunction in young rabbits after short term anabolic steroids administration

Cited by 30 publications

References 30 publications

Nandrolone Decanoate Is Prooxidant in the Myocardium of Exercised or Sedentary Rats

Nandrolone Decanoate Is Prooxidant in the Myocardium of Exercised or Sedentary Rats

Oxidative Stress in Muscle Growth and Adaptation to Physical Exercise

Reactive oxygen species: players in the cardiovascular effects of testosterone

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