Oxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?

Deveci, Erdem; Kocacenk, Tuba; Şahan, Ebru; Yılmaz, Onur; Öztürk, Ahmet; Kırpınar, İsmet

doi:10.1080/24750573.2019.1589176

Cited by 10 publications

(15 citation statements)

References 77 publications

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“…The result of the comparison of [TOS] levels terms of gender(Table 2) show that in bothsera and saliva samples, a highly significant increase is obvious (P˂ 0.001) between the patients subgroup compared compared with healthy control [21] . As well as with Sezeret al [22] andSkoieet al [23] who studiedmalondialdehyde (anend product marker of lipid peroxidation)sera samples.Ourfinding are consistent with those reported by other authors such as Tanhapouret alwho recorded an increased level of tissue malondialdehyde and oxidized low density lipoprotein [LDL] which are considered as markers of oxidative stress [24] .…”

Section: Resultsmentioning

confidence: 99%

The Oxidative Statues in Sera and Saliva of Iraqi Psoriasis Patients: A Correlation Study

Rasul¹,

Hasan²

2020

ATMPH

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Psoriasis is an autoimmune and inflammatory skin disease with reactive abnormal epidermal differentiation, in which genetic and environmental factors have a significant role. The aim of this study to look for the correlation between total oxidant status [TOS], total antioxidant status [TAS] andoxidative stress index [OSI] in serum of psoriatic with that of saliva. A Case study was carried on one hundred psoriatic patients and ninety three healthy individuals. The results showed a highly significantincrease (P<0.001) in serum and saliva TOS&OSI in patients group compared to the controls group. While serum & saliva TAS ofthe patients group showed a significant decrease (P<0.05) in comparison to controls group.When the comparison was done according to the gender, the results showed highly significantdifferences (P<0.001) in serum and saliva TOS&OSI between the different gender (female & male) of the patients subgroups compared to their corresponding controls group. Serum & saliva showed non-significant differencein [TAS] of both gender groups (P˃0.05).Our results found negative correlations between sera and saliva TOS&OSI (P<0.001).While a positive correlation was observed between TAS in sera sample with that in saliva sample (P˃0.05).

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Section: Resultsmentioning

confidence: 99%

The Oxidative Statues in Sera and Saliva of Iraqi Psoriasis Patients: A Correlation Study

Rasul¹,

Hasan²

2020

ATMPH

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“…The studies by Gisondi et al, 23 Colgecen et al 20 and Marek-J ozefowicz et al 21 mainly included patients with higher disease severity (mean PASI ≥ 15), resulting in the potential for selection bias. However, Deveci et al 32 also found lower cognitive test scores in mild psoriasis cases (most with PASI ≤ 5).…”

Section: Critical Appraisal Of the Evidencementioning

confidence: 94%

“…Deveci et al evaluated 37 psoriasis cases (most cases PASI ≤ 5) and 37 controls in a cross-sectional study. 32 Cognitive test score results were lower in patients with psoriasis compared with controls. Additionally, the blood levels of proinflammatory cytokines, a and IL-6, were significantly higher in patients with psoriasis.…”

Section: Cognitive Impairment In Patients With Psoriasismentioning

confidence: 94%

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Is psoriasis associated with dementia or cognitive impairment? A Critically Appraised Topic*

Yen

Chi

2020

Br J Dermatol

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Clinical question Is psoriasis associated with dementia or cognitive impairment? Background Psoriasis is a multisystemic inflammatory disorder that has an unclear association with cognitive dysfunction. Objectives To conduct a Critically Appraised Topic that synthesizes the results from relevant observational studies. Methods A systematic literature search of PubMed and Embase was conducted on 12 July 2019 to identify case-control, cross-sectional or cohort studies that investigated the association between psoriasis and cognitive impairment or dementia. Risk of bias was assessed for each study, and the results presented in a narrative synthesis. Results Eleven studies were included for critical appraisal. Of the 11 studies, 10 compared a total of 16 574 psoriasis cases with over 45 078 controls for risk of dementia or cognitive impairment. One of the 11 studies evaluated 7118 patients with dementia for odds of psoriasis compared with 21 354 controls. Six studies were assessed to have higher risk of bias. Nine of the 11 included studies found a significant positive association between the two diseases, one study a null association, and one study an inverse association. Discussion and recommendation Most of the 11 included studies found a positive association between psoriasis and either mild cognitive impairment or dementia. Brief cognitive assessments have been suggested to screen older patients with psoriasis who present with subjective cognitive complaints. What is already known about this topic? • Psoriasis and dementia are complex diseases with multifactorial pathogenesis, but share common inflammatory characteristics. • There is evidence for a shared genetic and inflammatory pathogenesis between the two entities. What does this study add? • Most observational studies found a significant positive association between psoriasis and cognitive impairment or dementia, and cognitive screening can be considered for patients with psoriasis who present with cognitive complaints. • There is currently not enough evidence to suggest one specific systemic antipsoriatic treatment over another for patients with psoriasis showing mild cognitive impairment or dementia.

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“…Psoriasis patients are more susceptible to mental health diseases than patients with other dermatological conditions [3]. It is recognized that the risk of depression, anxiety, and suicidality is higher in patients with psoriasis [4]. The impact of psoriasis on patients' lives can be assessed by different instruments, namely, the Psoriasis Disability Index (PDI) [5].…”

Section: Introductionmentioning

confidence: 99%

The Mediator Role of Body Image-Related Cognitive Fusion in the Relationship between Disease Severity Perception, Acceptance and Psoriasis Disability

Almeida

Leite

Constante

et al. 2020

Behavioral Sciences

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Psoriasis is a long-term skin disorder without a cure, whose patients are particularly susceptible to mental health diseases. Using a sample of patients diagnosed with psoriasis, this study aimed to: (1) identify the clinical and positive psychological variables that contribute the most to psoriasis disability and (2) assess the mediator role of body image-related cognitive fusion in the relation between disease severity perception and acceptance and self-compassion, on one hand, and psoriasis disability on the other. This is an initial cross-sectional exploratory study, with 75 patients diagnosed with psoriasis (males 52%; mean age 54.99 ± 13.72) answering a sociodemographic and a clinical questionnaire, the Psoriasis Disability Index (PDI), the Cognitive Fusion Questionnaire—Body Image (CFQ-BI), the Acceptance and Action Questionnaire—II (AAQ-II), and the Self-Compassion Scale (SCS). Descriptive and inferential statistics were used to characterize and assess the measures and the final model used. Through path analysis and a hierarchical multiple linear regression, it was found that the variables that significantly contributed to psoriasis disability were years of education, impact on social life and body image, explaining 70% of the variance. Body image-related cognitive fusion was a significant mediator in the relationship between disease severity and acceptance, and psoriasis disability. The implications of this study are considered to be extremely relevant, since it will allow additional information to be provided to psoriasis patients, appropriated to their educational level, aiming to reduce distorted perceptions of disease severity and intervene in the ability to accept this specific and important chronic health condition.

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Oxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?

Cited by 10 publications

References 77 publications

The Oxidative Statues in Sera and Saliva of Iraqi Psoriasis Patients: A Correlation Study

The Oxidative Statues in Sera and Saliva of Iraqi Psoriasis Patients: A Correlation Study

Is psoriasis associated with dementia or cognitive impairment? A Critically Appraised Topic*

The Mediator Role of Body Image-Related Cognitive Fusion in the Relationship between Disease Severity Perception, Acceptance and Psoriasis Disability

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