The Oxidative Statues in Sera and Saliva of Iraqi Psoriasis Patients: A Correlation Study

Abstract

Psoriasis is an autoimmune and inflammatory skin disease with reactive abnormal epidermal differentiation, in which genetic and environmental factors have a significant role. The aim of this study to look for the correlation between total oxidant status [TOS], total antioxidant status [TAS] andoxidative stress index [OSI] in serum of psoriatic with that of saliva. A Case study was carried on one hundred psoriatic patients and ninety three healthy individuals. The results showed a highly significantincrease (P<0.001) in serum and saliva TOS&OSI in patients group compared to the controls group. While serum & saliva TAS ofthe patients group showed a significant decrease (P<0.05) in comparison to controls group.When the comparison was done according to the gender, the results showed highly significantdifferences (P<0.001) in serum and saliva TOS&OSI between the different gender (female & male) of the patients subgroups compared to their corresponding controls group. Serum & saliva showed non-significant differencein [TAS] of both gender groups (P˃0.05).Our results found negative correlations between sera and saliva TOS&OSI (P<0.001).While a positive correlation was observed between TAS in sera sample with that in saliva sample (P˃0.05).

Impact of psoriasis disease and its treatment with Etanercept on serum and saliva thiol-disulfide homeostasis

“…The results of the present study indicated that the thiol-disulfide status play an important role in the oxidative stress measured previously in the patients included in the study (14) and using the biological drug ETN seems to improve the in-balance observed in this status. Moreover the current data provide evidence of the possibility of using saliva, as an alternative fluid instead of blood serum, to detect changes in the level of some thiol homeostasis related parameters, as well as to follow the impact of ETN treatment on these parameters.…”

“…Dynamic/Native ratio, Dynamic/Total ratio and Native/Total ratio parameters in saliva andserum. It has been reported that oxidative stress (OS) play an important role in the pathogenesis of many diseases including inflammatory diseases and some new studies have reported the role of oxidative stress in the pathogenesis of psoriasis [14,18]. The chemotactic effect of ROS on neutrophils contributes to the accumulation of the various inflammatory cells in psoriasis lesions [34], and the ROS generated by TNF-alpha in keratinocytes are responsible for initiating and maintaining chronic inflammation by regulation of certain pathways that are involved in the inflammatory process [15,34].…”

“…Throughout the last few years different chemicals such as aldehydes, phenols, hydrocarbons, nitric oxide (NO), Quinone and semi Quinone radical, which are directly or indirectly lead to the formation of free radical, are recognized to be present in the patients psoriasis [13]. And one of the remarkable features, which few recent researches have pointed to in psoriatic patients, is the involvement of oxidative stress (OS) in this disease pathogenesis [11,14,15]. The OS can be defined as in-balance between the oxidants and antioxidants present within the body which results in accumulation of free radicals in different forms of reactive species [16,17].…”

“…Generally to prevent the occurrence of the oxidative stress the body has a defense system known as antioxidants which are of two classes: enzymatic and none enzymatic, these antioxidants are nucleophile molecules that interact with the present reactive species to counteract their toxic effects on the different bio-components and thus prevent cell damage [22,23]. Among the non-enzymatic antioxidants is the thiols that represent very potent antioxidants through acting as electron donors thus reducing unstable free radicals [24].Thiol homeostasis is increasingly implicated in many disorders and psoriasis is one of them [14,15,23].Now-days, there has been a rapid rise in using thiol/disulfide measurements to evaluate the free radical status in an organism both at physiological and pathological conditions, therefore determination of this homeostasis can provide valuable information on various normal, or abnormal biochemical processes [25,26,27,28]. Treatment of psoriasis is based on the disease severity and includes topical therapies for milder patients, phototherapy for mild to moderate disease, and oral systemic biological agents in patients with moderate to severe skin disease [29].…”