Oxidative stress and inflammatory markers are associated with depression and nicotine dependence

Vargas, Heber Odebrecht; Nunes, Sandra Odebrecht Vargas; Castro, Márcia Regina Pizzo de; Vargas, Mateus Mendonça; Barbosa, Décio Sabbatini; Bortolasci, Chiara C.; Venugopal, Kamalesh; Dodd, Seetal; Berk, Michael

doi:10.1016/j.neulet.2013.03.059

Cited by 86 publications

(54 citation statements)

References 30 publications

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“…This study showed that there was a higher statistical significant difference among smokers concerning the level of Malondialdehyde (MDA) compared to non-smokers. These findings were in agreement with other studies which detected that Malondialdehyde levels were significantly increased in cigarette smokers (30,(34)(35)(36) . Also there is lower statistical significant difference regarding the level of superoxide dismutase (SOD) among smokers compared to non-smokers.…”

Section: Discussionsupporting

confidence: 94%

Assessment of Oxidative Stress and Antioxidant Status Among Petrol Stations’ Workers Exposed to Benzene in Zagazig City

Hassan

El-Magd

Ghareeb³

et al. 2013

Zagazig University Medical Journal

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Section: Discussionsupporting

confidence: 94%

Assessment of Oxidative Stress and Antioxidant Status Among Petrol Stations’ Workers Exposed to Benzene in Zagazig City

Hassan

El-Magd

Ghareeb³

et al. 2013

Zagazig University Medical Journal

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“…Erythrocyte sedimentation rate (ESR) -higher ESR was identified in depressed patients compared to healthy volunteers (Chavda et al, 2011), and in depressed smokers compared to nondepressed, never smokers (Vargas et al, 2013). ESR was also elevated in rheumatoid arthritis (RA) patients suffering from depression compared to non-depressed RA sufferers (Abdel-Nasser et al,…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Lopresti

Maker

Hood

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

290

173

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Biomarkers are regularly used in medicine to provide objective indicators of normal biological processes, pathogenic processes or pharmacological responses to therapeutic interventions, and have proved invaluable in expanding our understanding and treatment of medical diseases. In the field of psychiatry, assessment and treatment has, however, primarily relied on patient interviews and questionnaires for diagnostic and treatment purposes. Biomarkers in psychiatry present a promising addition to advance the diagnosis, treatment and prevention of psychiatric diseases. This review provides a summary on the potential of peripheral biomarkers in major depression with a specific emphasis on those related to inflammatory/immune and oxidative stress/antioxidant defences. The complexities associated with biomarker assessment are reviewed specifically around their collection, analysis and interpretation. Focus is placed on the potential of peripheral biomarkers to aid diagnosis, predict treatment response, enhance treatment-matching, and prevent the onset or relapse of major depression.

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“…Nicotine (Vargas et al 2013) and lead exposure (Patra et al 2011) can significantly increase free radical activity and subsequent O&NS.…”

Section: Potential Causes Of Oandns In Adhdmentioning

confidence: 99%

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies

Lopresti

2015

ADHD Atten Def Hyp Disord

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Attention deficit hyperactivity disorder (ADHD) has a complex etiology although theories associated with disturbances in dopaminergic and noradrenergic activity are most commonly cited.The importance of these catecholamines in ADHD is supported by its effective treatment utilising stimulant and non-stimulant medications that modify their activity. Recently there has been interest in oxidative and nitrosative stress (O&NS) in ADHD and its potential to contribute to this condition. In this article, research investigating O&NS in ADHD is reviewed and its impact on catecholaminergic activity and neurological structure is discussed. Lifestyle, environmental, ADHD is most commonly treated with stimulant medications such as methylphenidate and amphetamines, non-stimulants such as atomoxetine, and alpha2-adrenergic agonists such as clonidine and guanfacine. Through their effects on dopamine and noradrenaline transporters, stimulants inhibit the reuptake of dopamine and noradrenaline, thereby increasing the extracellular levels of these neurotransmitters. These stimulants also inhibit monoamine oxidase, the enzyme that metabolises these catecholamines (Wilens et al. 2011). Atomoxetine works as a selective reuptake inhibitor of noradrenaline leading to its increased extracellular concentration (Garnock- Jones and Keating 2009).While effective, these medications are associated with several adverse effects. These include loss of appetite, growth delay and sleep disturbances (Cortese et al. 2013). It is important to note that despite their widely accepted short-term efficacy, the long-term effectiveness of pharmacological treatments on social, educational and occupational functioning in people with ADHD continues to be debated (Huang and Tsai 2011;Langberg and Becker 2012;Nijmeijer et al. 2008). On a positive note, recent analyses using the Swedish national registrar suggests that long-term stimulant use in people with ADHD is associated with reduced rates of substance use, criminality, and serious traffic accidents (Chang et al. 2014a;Chang et al. 2014b;Lichtenstein et al. 2012).Despite wide appreciation of catecholaminergic theories associated with ADHD, there has been increased research into other biological mechanisms associated with ADHD. For example, in psychiatry there has been interest in immune-inflammatory pathways and oxidative and nitrosative stress (O&NS). In particular, it has been confirmed through recent meta-analyses that depression is Increased O&NS has also been found in bipolar disorder (Andreazza et al. 2008;Brown et al. 2014),

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Oxidative stress and inflammatory markers are associated with depression and nicotine dependence

Cited by 86 publications

References 30 publications

Assessment of Oxidative Stress and Antioxidant Status Among Petrol Stations’ Workers Exposed to Benzene in Zagazig City

Assessment of Oxidative Stress and Antioxidant Status Among Petrol Stations’ Workers Exposed to Benzene in Zagazig City

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies

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