Assessment of Oxidative Stress and Antioxidant Status Among Petrol Stations’ Workers Exposed to Benzene in Zagazig City

Hassan, Ali; El-Magd, Sahar A. Abou; Ghareeb, Amal F.; Bolbol, Sarah A.

doi:10.21608/zumj.2013.4312

Cited by 7 publications

(8 citation statements)

References 21 publications

(32 reference statements)

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“…and Hassan et al . also reported similar finding for the workers exposed at leather tanneries and gasoline stations, respectively 22 , 68 . For the control group in this study, a significant positive correlation was found between SOD activity, the age of the worker, and working duration ( p < 0.05).…”

Section: Discussionsupporting

confidence: 76%

Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan

Junaid

Hashmi

Tang

et al. 2017

Sci Rep

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This is a systematical report on the potential health risk of heavy metals from the leather industries in Pakistan based on multiple biological matrices of the exposed workers and indoor dust samples. The adverse impacts of heavy metals on the oxidative enzyme and their risks to workers’ health were also explored. Our results indicated that the level of Cr in indoor industrial dust was more than twice, compared to the background household dust. Blood, urine and hair samples of exposed workers showed significantly high concentrations of heavy metals, compared to those in the control group. Superoxide dismutase (SOD) level in the blood samples expressed significant positive correlation with Cr and Ni. Total hazard quotients (HQs)/hazard index (HI) were >1, and Cr (VI) exhibited higher cancer risks than that of Cd in the exposed workers. In addition, the PCA-MLR analysis confirmed that the industrial sections; cutting, shivering/crusting, and stitching were the principal contributors of heavy metals in the biological entities of the workers. Taken together, our results highlighted the occupationally exposed groups would likely to experience the potential health risks due to excessive exposure to the heavy metals from the leather industries.

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Section: Discussionsupporting

confidence: 76%

Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan

Junaid

Hashmi

Tang

et al. 2017

Sci Rep

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“…Finally, for a more comprehensive assessment of TAC in the body, some OS questionnaires with questions comprising food intake, smoking, physical activity, sleeping patterns, drinking and radiation [ 306 ] exist, but their validation in a scientific context or use in clinical research has been limited [ 306 ]. Such questionnaires have rather been employed in acute OS exposure phases due to a specific environmental context such as benzene or malaria exposure [ 307 , 308 ]. More comprehensive questionnaires and indices taking into consideration a global assessment of the antioxidant capacity and OS, and not only dietary factors should be targeted, especially in the context of non-communicable diseases.…”

Section: Markers Of Os Relation To Disease and Practical Aspectsmentioning

confidence: 99%

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Menzel¹,

Samouda

Dohet³

et al. 2021

Antioxidants

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Many chronic conditions such as cancer, chronic obstructive pulmonary disease, type-2 diabetes, obesity, peripheral/coronary artery disease and auto-immune diseases are associated with low-grade inflammation. Closely related to inflammation is oxidative stress (OS), which can be either causal or secondary to inflammation. While a low level of OS is physiological, chronically increased OS is deleterious. Therefore, valid biomarkers of these signalling pathways may enable detection and following progression of OS/inflammation as well as to evaluate treatment efficacy. Such biomarkers should be stable and obtainable through non-invasive methods and their determination should be affordable and easy. The most frequently used inflammatory markers include acute-phase proteins, essentially CRP, serum amyloid A, fibrinogen and procalcitonin, and cytokines, predominantly TNFα, interleukins 1β, 6, 8, 10 and 12 and their receptors and IFNγ. Some cytokines appear to be disease-specific. Conversely, OS—being ubiquitous—and its biomarkers appear less disease or tissue-specific. These include lipid peroxidation products, e.g., F2-isoprostanes and malondialdehyde, DNA breakdown products (e.g., 8-OH-dG), protein adducts (e.g., carbonylated proteins), or antioxidant status. More novel markers include also –omics related ones, as well as non-invasive, questionnaire-based measures, such as the dietary inflammatory-index (DII), but their link to biological responses may be variable. Nevertheless, many of these markers have been clearly related to a number of diseases. However, their use in clinical practice is often limited, due to lacking analytical or clinical validation, or technical challenges. In this review, we strive to highlight frequently employed and useful markers of inflammation-related OS, including novel promising markers.

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“…Penelitian lain yang menunjukkan adanya hubungan paparan benzene dengan tingkat stres oksidatif yaitu penelitian Hasan et al pada 43 orang pekerja pom bensin terpapar benzene dan 40 orang kontrol, dilaporkan tingkat metabolit benzene pekerja pom bensin lebih tinggi dan menginduksi stres oksidatif, ditandai dengan tingginya kadar MDA dan rendahnya kadar SOD dibandingkan kontrol. (22) Wetmore et al melaporkan tikus terpapar 50 ppm benzene secara sendiri atau bersama antara 50 ppm benzene dan 100 ppm toluena, menunjukkan terjadinya penurunan kadar GSH. (6) Peningkatan aktivitas GGT merupakan respon pertahanan dari detoksifikasi metabolit toksik hasil produksi proses metabolisme benzene.…”

Section: Kadar Ggtunclassified

Pengaruh suplementasi vitamin e (α-tokoferol) terhadap kadar gamma glutamil transferase (ggt) dan kadar nitric oxide (no) pada tikus (Studi pada tikus rattus novergicus strain wistar jantan terpapar inhalasi uap benzene)

Roziana¹,

Subagio

Suhartono

et al. 2016

JGI

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Assessment of Oxidative Stress and Antioxidant Status Among Petrol Stations’ Workers Exposed to Benzene in Zagazig City

Cited by 7 publications

References 21 publications

Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan

Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Pengaruh suplementasi vitamin e (α-tokoferol) terhadap kadar gamma glutamil transferase (ggt) dan kadar nitric oxide (no) pada tikus (Studi pada tikus rattus novergicus strain wistar jantan terpapar inhalasi uap benzene)

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