Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis

Moreno‐Solís, Gloria; Torre-Aguilar, María José de la; Torres-Borrego, J.; Llorente-Cantarero, Francisco J.; Fernández‐Gutiérrez, Fernando; Gil‐Campos, Mercedes; Túnez‐Fiñana, Isaac; Pérez-Navero, Juan Luís

doi:10.1111/crj.12425

Cited by 27 publications

(22 citation statements)

References 39 publications

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“…Elevation of total ROS levels in A549 airway cells is also triggered by HRSV [ 31 , 32 ] and in various cell lines by SeV [ 33 , 34 ], as was shown with DCFHDA. Consistently, the accumulation of lipid peroxidation products and oxidized glutathione (GSH) were reported in plasma of infants with HRSV-induced acute bronchiolitis [ 35 ]. SeV, as shown above for IV, also triggers the induction of iNOS, enhanced production of nitric oxide, and accumulation of nitroguanosine [ 36 ].…”

Section: Enhanced Ros Production During Viral Respiratory Infectiomentioning

confidence: 70%

“…Therefore, various agents have been evaluated and they are used as remedies to target not only the viruses but also the virus-associated inflammation. Much attention has been paid to antioxidants due to the correlation between severity of lung injury and the markers of oxidative stress in lung and blood of patients that are infected with HRSV [ 35 , 37 ] or IV [ 24 , 54 ]. Here, we briefly summarize the major findings for treatment of respiratory infections with antioxidants.…”

Section: Antioxidant Therapy Of Respiratory Virusesmentioning

confidence: 99%

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Redox Biology of Respiratory Viral Infections

Khomich

Kochetkov

Bartosch

et al. 2018

Viruses

331

346

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Respiratory viruses cause infections of the upper or lower respiratory tract and they are responsible for the common cold—the most prevalent disease in the world. In many cases the common cold results in severe illness due to complications, such as fever or pneumonia. Children, old people, and immunosuppressed patients are at the highest risk and require fast diagnosis and therapeutic intervention. However, the availability and efficiencies of existing therapeutic approaches vary depending on the virus. Investigation of the pathologies that are associated with infection by respiratory viruses will be paramount for diagnosis, treatment modalities, and the development of new therapies. Changes in redox homeostasis in infected cells are one of the key events that is linked to infection with respiratory viruses and linked to inflammation and subsequent tissue damage. Our review summarizes current knowledge on changes to redox homeostasis, as induced by the different respiratory viruses.

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Section: Enhanced Ros Production During Viral Respiratory Infectiomentioning

confidence: 70%

Section: Antioxidant Therapy Of Respiratory Virusesmentioning

confidence: 99%

Redox Biology of Respiratory Viral Infections

Khomich

Kochetkov

Bartosch

et al. 2018

Viruses

331

346

View full text Add to dashboard Cite

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“…Markers of oxidative stress resulting from lipid peroxidation—malondialdehyde (MDA)—or fatty acid peroxidation—F2-8-Isoprostane—were found elevated in the nasopharyngeal secretions (NPS) of RSV-infected children [ 73 ]. Oxidative stress, measured by decreased glutathione (GSH)/oxidized glutathione (GSSG) ratio, was also measured in blood samples of RSV-infected infants exhibiting RSV-associated acute bronchiolitis [ 74 ]. Importantly, oxidative stress marker levels in the lung and blood were positively correlated with the severity of the bronchiolitis [ 73 , 74 ].…”

Section: Reactive Oxygen Species (Ros) During Rsv Infection: Too Mmentioning

confidence: 99%

“…Oxidative stress, measured by decreased glutathione (GSH)/oxidized glutathione (GSSG) ratio, was also measured in blood samples of RSV-infected infants exhibiting RSV-associated acute bronchiolitis [ 74 ]. Importantly, oxidative stress marker levels in the lung and blood were positively correlated with the severity of the bronchiolitis [ 73 , 74 ]. Although these in vivo observations in children are indicative of a role of RSV in the induction of oxidative stress, these data should be interpreted with caution.…”

Section: Reactive Oxygen Species (Ros) During Rsv Infection: Too Mmentioning

confidence: 99%

Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology

Cervantes-Ortiz

Cuervo

2016

Viruses

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Human respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, is a major cause of severe acute lower respiratory tract infection in infants, elderly and immunocompromised adults. Despite decades of research, a complete integrated picture of RSV-host interaction is still missing. Several cellular responses to stress are involved in the host-response to many virus infections. The endoplasmic reticulum stress induced by altered endoplasmic reticulum (ER) function leads to activation of the unfolded-protein response (UPR) to restore homeostasis. Formation of cytoplasmic stress granules containing translationally stalled mRNAs is a means to control protein translation. Production of reactive oxygen species is balanced by an antioxidant response to prevent oxidative stress and the resulting damages. In recent years, ongoing research has started to unveil specific regulatory interactions of RSV with these host cellular stress responses. Here, we discuss the latest findings regarding the mechanisms evolved by RSV to induce, subvert or manipulate the ER stress, the stress granule and oxidative stress responses. We summarize the evidence linking these stress responses with the regulation of RSV replication and the associated pathogenesis.

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“…It is important to know whether it is the initial epithelial injury that is responsible for severity and sequelae, or whether the inflammatory response to the viral agent predisposes the patient to relapses. Much effort has been made to identify novel biological markers measurable during the course of acute bronchiolitis for clinically effective prediction of disease severity and later wheezing . Our team has studied epithelial injury biomarkers in acute bronchiolitis, but found no correlation between serum levels of KL‐6 2 , or serum‐soluble receptor for advanced glycation end‐product, and severity of acute bronchiolitis and risk of wheezing bronchitis.…”

Section: Introductionmentioning

confidence: 99%

Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis

Egron

Labbé²,

Rochette

et al. 2019

Pediatric Pulmonology

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Acute bronchiolitis is responsible for high morbidity in infants. Club cell protein 16 kDa (CC16) is a major pneumoprotein secreted by club cells of the bronchial epithelium and eliminated by the renal pathway. CC16 seems to be a biomarker of epithelial damage in asthma. However, its value as a marker of acute bronchiolitis severity and later recurrent wheezing are uncertain, especially the value of its urinary assay for this purpose. A prospective, observational, analytical study was conducted at Clermont‐Ferrand University Hospital to correlate serum CC16 level with clinical severity of bronchiolitis in hospitalized infants aged less than 1 year. We analyzed correlations between serum and urinary CC16, CC16 levels and Wainwright score, immediate morbidity due to bronchiolitis, causal viruses, and recurrent wheezing 1 year after inclusion. In 166 infants, serum CC16 did not correlate with acute bronchiolitis severity (P = .49), but urinary CC16 did (P < .001). In multivariate analysis, urinary CC16 correlated mainly with urinary retinol binding protein (RBP; r = 0.70; P < .001). The logCC16u/logRBPu ratio correlated significantly with severity (P = .02). CC16 levels were not correlated with recurrent wheezing at 1 year. Urinary CC16 could be a useful biomarker in acute bronchiolitis for specific indications. This noninvasive assay would be particularly useful in the young infant population. Several factors must be taken into account in its interpretation, mainly tubular function. Further studies are needed to assess these factors.

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Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis

Abstract: RSV induced OS in AB. An increase in GSSG correlated with the disease severity in the infants. OS may contribute to the pathogenesis of RSV-AB.

Cited by 27 publications

References 39 publications

Redox Biology of Respiratory Viral Infections

Redox Biology of Respiratory Viral Infections

Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology

Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis

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