Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis

Egron, Carole; Labbé, A.; Rochette, Emmanuelle; Mulliez, Aurélien; Bernard, Alfred; Flore, Amat

doi:10.1002/ppul.24584

Cited by 14 publications

(17 citation statements)

References 30 publications

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“…Viral infections have an impact on SCGB1A1 levels: urine levels of SCGB1A1 are elevated in infants with acute bronchiolitis 41 and also children infected with respiratory syncytial virus (RSV) show elevated serum levels of the protein 42 . The susceptibility for viral infections may depend on the patient's serum SCGB1A1 levels: a study including elite athletes associated lower serum SCGB1A1 levels with a higher susceptibility to viral infections 43 .…”

Section: Secretoglobins In Diseases Of the Upper And Lower Airwaysmentioning

confidence: 99%

Secretoglobins in the big picture of immunoregulation in airway diseases

Mootz

Jakwerth

Schmidt‐Weber

et al. 2021

Allergy

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The proteins of the secretoglobin (SCGB) family are expressed by secretory tissues of barrier organs. They are embedded in immunoregulatory and anti‐inflammatory processes of airway diseases. This review particularly illustrates the immune regulation of SCGBs by cytokines and their implication in the pathophysiology of airway diseases. The biology of SCGBs is a complex topic of increasing importance, as they are highly abundant in the respiratory tract and can also be detected in malignant tissues and as elements of immune control. In addition, SCGBs react to cytokines, they are embedded in Th1 and Th2 immune responses, and they are expressed in a manner dependent on cell maturation. The big picture of the SCGB family identifies these factors as critical elements of innate immune control at the epithelial barriers and highlights their potential for diagnostic assessment of epithelial activity. Some members of the SCGB family have so far only been superficially examined, but have high potential for translational research.

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Section: Secretoglobins In Diseases Of the Upper And Lower Airwaysmentioning

confidence: 99%

Secretoglobins in the big picture of immunoregulation in airway diseases

Mootz

Jakwerth

Schmidt‐Weber

et al. 2021

Allergy

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“…However, serum CC16 levels were found to be similar in children infected with influenza or parainfluenza virus compared with healthy controls [ 62 ]. Recently, Egron et al measured both serum and urinary CC16 from the infants aged under 1 year hospitalized for acute bronchiolitis and found a urinary increase in CC16 correlating to the severity of acute bronchiolitis, suggesting the potential utility of urinary CC16 as a biomarker in acute bronchiolitis [ 63 ]. In adults, it has been reported that athletes who suffer from recurrent respiratory infections had significantly lower serum CC16 than controls, which might lead to the increased susceptibility to respiratory infections in athletes [ 64 ].…”

Section: Cc16 In Respiratory Infectionsmentioning

confidence: 99%

“…That is because nasal and sputum were not considered for CC16 measurements in most studies and when considered, the results were not comparable. Interestingly, CC16 from urine could be an accurate assessment for lung abnormality in children, such as asthma [ 73 ] and acute bronchiolitis [ 63 ]. Thus, we strongly recommend measuring CC16 from serum in adults and urine in children.…”

Section: Summary Conclusion and Future Perspectivesmentioning

confidence: 99%

Club Cell Secreted Protein CC16: Potential Applications in Prognosis and Therapy for Pulmonary Diseases

Almuntashiri

Zhu

Han

et al. 2020

JCM

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Club cell secretory protein (CC16) is encoded by the SCGB1A1 gene. It is also known as CC10, secretoglobin, or uteroglobin. CC16 is a 16 kDa homodimeric protein secreted primarily by the non-ciliated bronchial epithelial cells, which can be detected in the airways, circulation, sputum, nasal fluid, and urine. The biological activities of CC16 and its pathways have not been completely understood, but many studies suggest that CC16 has anti-inflammatory and anti-oxidative effects. The human CC16 gene is located on chromosome 11, p12-q13, where several regulatory genes of allergy and inflammation exist. Studies reveal that factors such as gender, age, obesity, renal function, diurnal variation, and exercise regulate CC16 levels in circulation. Current findings indicate CC16 not only may reflect the pathogenesis of pulmonary diseases, but also could serve as a potential biomarker in several lung diseases and a promising treatment for chronic obstructive pulmonary disease (COPD). In this review, we summarize our current understanding of CC16 in pulmonary diseases.

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“…Club cell protein 16 (CC16) is the most abundant protein in the bronchoalveolar lavage fluid ( 29 , 30 ). It is encoded by the secretoglobin family 1A member 1 gene and serves an anti-inflammatory and antioxidant role in vivo ( 29 , 30 ).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D3 alleviates cigarette smoke extract‑mediated epithelial‑mesenchymal transition and fibrogenesis by upregulating CC16 expression in bronchial epithelial cells

Mao

Feng

2022

Exp Ther Med

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Vitamin D3 supplementation has been previously reported to inhibit the occurrence and development of chronic obstructive pulmonary disease (COPD). However, the underlying mechanism remains unclear. Epithelial-mesenchymal transition (EMT) and fibrogenesis have been associated with the development of COPD. The aim of the present study was to investigate the potential effects and mechanism of vitamin D3 in an in vitro model of cigarette smoke (CS)-induced EMT and fibrosis, with specific focus on the role of club cell protein 16 (CC16). CS extract (CSE) at different concentrations (5, 10 and 20%) was used to treat 16-HBE cells to induce EMT and fibrogenesis following which they were treated with vitamin D3. Subsequently, the 20% CSE group was selected for further experiments, where 16-HBE cells were divided into the following five groups: The control group; the CSE group; the low-dose vitamin D3 group (250 nM); the medium-dose vitamin D3 group (500 nM); and the high-dose vitamin D3 group (1,000 nM). Western blot analysis was used to detect the protein expression levels of the EMT-related proteins E-cadherin, N-cadherin, Slug and α-SMA, fibrogenesis-related proteins collagen Ⅳ and fibronectin 1, proteins involved in the TGF-β1/SMAD3 signaling pathway and CC16. Immunofluorescence was used to measure the protein expression levels of E-cadherin, N-cadherin and collagen Ⅳ. Specific CC16 knockdown was performed using short hairpin RNA transfection to investigate the role of CC16. The results of the present study found that vitamin D3 could increase the protein expression level of CC16 to inhibit the activation of the TGF-β1/SMAD3 signaling pathway; thereby reducing the 20% increase in CSE-induced EMT- and fibrogenesis-related protein expression levels. Following CC16 knockdown, the inhibitory effects of vitamin D3 on EMT- and fibrogenesis-related protein expression were partially reversed. To conclude, these results suggest that vitamin D3 can inhibit the protein expression levels of EMT- and fibrogenesis-related proteins induced by CSE, at least partially through the function of CC16. These findings are expected to provide novel theoretical foundations and ideas for the pathogenesis and treatment of COPD.

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Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis

Cited by 14 publications

References 30 publications

Secretoglobins in the big picture of immunoregulation in airway diseases

Secretoglobins in the big picture of immunoregulation in airway diseases

Club Cell Secreted Protein CC16: Potential Applications in Prognosis and Therapy for Pulmonary Diseases

Vitamin D3 alleviates cigarette smoke extract‑mediated epithelial‑mesenchymal transition and fibrogenesis by upregulating CC16 expression in bronchial epithelial cells

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