Oxidative stress and DNA damage in patients with migraine

Geyik, Sırma; Altunışık, Erman; Neyal, Abdurrahman; Taysı, Seyithan

doi:10.1186/s10194-016-0606-0

Cited by 83 publications

(76 citation statements)

References 27 publications

(29 reference statements)

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“…Although the role of neurogenic inflammation and possibly immune dysfunction in migraine pathophysiology has gained much attention over the last few decades, the exact pathogenesis of migraine headache has not been fully understood as yet. The involvement of the inflammatory system in this process may be mediated through different mechanisms including augmented levels of proinflammatory factors in the nervous system and increased release of a number of neuro‐inflammatory factors (eg, NO, CGRP, SP, vasoactive intestinal peptide [VIP], glutamate [Glu], pituitary adenylate cyclase‐activating polypeptide [PACAP], and neurokinin A) that result in vasodilation in arteries and disturbances in the regulation of mast cells and ultimately pain sensitization in the head . On the other hand, the potential anti‐inflammatory and immune regulating abilities of vitamin D can be beneficial in reducing the risk of migraine occurrence in susceptible individuals.…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin D Status in a Group of Migraine Patients Compared With Healthy Controls: A Case–Control Study

et al. 2018

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Objective The association between serum vitamin D and migraine is investigated in this research.s Background Although the pathogenesis of migraine headache is not fully understood, the possible role of inflammation and disturbed immune system has been proposed; thus, higher levels of vitamin D might reduce the risk of migraine. However, the results of related studies have been inconclusive. Methods Seventy healthy individuals and 70 age‐ and sex‐matched migraineurs (34 chronic and 36 episodic migraineurs), diagnosed according to the International Headache Society criteria (ICHD‐IIIβ), were recruited. After obtaining baseline data and assessing migraine disability, a 30‐day headache diary was given to the participants. Blood samples were obtained and 25(OH)D serum concentrations were determined using ELISA techniques. Serum 25(OH)D under 20, 20–29, and 30–100 ng/mL were considered deficient, insufficient, and sufficient, respectively. The applied statistical tests for between‐group comparisons include independent‐sample t‐test, chi‐square, and analysis of variance. Multiple regression analysis was also performed to identify the possible risk factors of migraine headache. Results Migraine patients had significantly lower mean (SD) of serum VitD (30 (16) ng/mL) than healthy subjects (43 (19) ng/mL) (P < .001). The number (%) of subjects with VitD deficiency and insufficiency was significantly higher among the migraineurs (36 (53.7%)) than the controls (18 (26.1%)) (P < .0001). A significant negative association between migraine headache and serum VitD was detected in the fully adjusted multiple regression models when comparing the third and the highest serum 25(OH)D quartiles with the lowest (OR = 0.20; 95% CI = 0.05–0.77; OR = 0.17; 95% CI = 0.04–0.64, respectively, P for trend = .009). For each 5 ng/mL increase in serum 25(OH)D, there was a 22% odds decrease in the odds of migraine (OR = 0.78; 95% CI = 0.68–0.90; P = .001). Conclusion We have found that a higher level of serum VitD (between 50 to less than 100 ng/mL) among a sample of the Iranian population is associated with 80–83% lower odds of migraine headache than those with serum 25(OH)D levels below 20 ng/mL. However, there is a need for well‐designed clinical trials to investigate beneficial effects of increased serum 25(OH)D on lower risk of migraine.

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Section: Discussionmentioning

confidence: 99%

Serum Vitamin D Status in a Group of Migraine Patients Compared With Healthy Controls: A Case–Control Study

et al. 2018

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“…Vulnerability to migraines is not completely understood but may be in part related to higher levels of lipid peroxides found in plasma, platelets, and urine of migraineurs between attacks . Lipid peroxides are oxidation products and thus a biomarker of oxidative stress .…”

Section: Migraines and Oxidative Stressmentioning

confidence: 99%

The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress: Preliminary Evidence for a Theory

Borkum

2017

Headache

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Background.-Previous research has suggested that migraineurs show higher levels of oxidative stress (lipid peroxides) between migraine attacks and that migraine triggers may further increase brain oxidative stress. Oxidative stress is transduced into a neural signal by the TRPA1 ion channel on meningeal pain receptors, eliciting neurogenic inflammation, a key event in migraine. Thus, migraines may be a response to brain oxidative stress.Results.-In this article, a number of migraine components are considered: cortical spreading depression, platelet activation, plasma protein extravasation, endothelial nitric oxide synthesis, and the release of serotonin, substance P, calcitonin gene-related peptide, and brain-derived neurotrophic factor. Evidence is presented from in vitro research and animal and human studies of ischemia suggesting that each component has neuroprotective functions, decreasing oxidant production, upregulating antioxidant enzymes, stimulating neurogenesis, preventing apoptosis, facilitating mitochondrial biogenesis, and/or releasing growth factors in the brain. Feedback loops between these components are described. Limitations and challenges to the model are discussed.Conclusions.-The theory is presented that migraines are an integrated defensive, neuroprotective response to brain oxidative stress.

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“…ROS causes lipid, protein and DNA oxidation, which are structural elements in cells (31,32). Upon lipid and protein oxidation in the cell membrane, the cells become susceptible for penetration and their integrity disrupted.…”

Section: Discussionmentioning

confidence: 99%

Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

Huyut¹,

Şekeroğlu²,

Hakan³

et al. 2018

Eastern J Med

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Oxidative stress and DNA damage in patients with migraine

Cited by 83 publications

References 27 publications

Serum Vitamin D Status in a Group of Migraine Patients Compared With Healthy Controls: A Case–Control Study

Serum Vitamin D Status in a Group of Migraine Patients Compared With Healthy Controls: A Case–Control Study

The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress: Preliminary Evidence for a Theory

Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

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