Oxidative stress and diabetic retinopathy

Tekin, Kemal; Tekin, Merve Inanc

doi:10.1016/b978-0-12-815972-9.00003-2

Cited by 4 publications

(4 citation statements)

References 75 publications

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“…It is generally accepted that oxidative stress has a fundamental role in vascular dysfunction [86]. In diabetic retinopathy, oxidative stress-induced decreased nitric oxide bioavailability contributes to endothelial cell dysfunction, basement membrane thickening, and pericyte apoptosis, resulting in altered microvasculature [87]. Lipid peroxidation is one of the major mechanisms of oxidative damage [88].…”

Section: The Landscape Of Rosmentioning

confidence: 99%

Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes

Arabshomali,

Bazzazzadehgan,

Mahdi

et al. 2023

Molecules

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The clinical relationship between diabetes and inflammation is well established. Evidence clearly indicates that disrupting oxidant-antioxidant equilibrium and elevated lipid peroxidation could be a potential mechanism for chronic kidney disease associated with type 2 diabetes mellitus (T2DM). Under diabetic conditions, hyperglycemia, especially inflammation, and increased reactive oxygen species generation are bidirectionally associated. Inflammation, oxidative stress, and tissue damage are believed to play a role in the development of diabetes. Although the exact mechanism underlying oxidative stress and its impact on diabetes progression remains uncertain, the hyperglycemia-inflammation-oxidative stress interaction clearly plays a significant role in the onset and progression of vascular disease, kidney disease, hepatic injury, and pancreas damage and, therefore, holds promise as a therapeutic target. Evidence strongly indicates that the use of multiple antidiabetic medications fails to achieve the normal range for glycated hemoglobin targets, signifying treatment-resistant diabetes. Antioxidants with polyphenols are considered useful as adjuvant therapy for their potential anti-inflammatory effect and antioxidant activity. We aimed to analyze the current major points reported in preclinical, in vivo, and clinical studies of antioxidants in the prevention or treatment of inflammation in T2DM. Then, we will share our speculative vision for future diabetes clinical trials.

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Section: The Landscape Of Rosmentioning

confidence: 99%

Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes

Arabshomali,

Bazzazzadehgan,

Mahdi

et al. 2023

Molecules

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“…It has been widely accepted that oxidative stress caused by the imbalance of generation and detoxification of free radicals can lead to aging [ 28 ], and diverse diseases such as diabetic retinopathy [ 29 ], Alzheimer’s disease and Parkinson’s disease [ 30 ]. Therefore, finding more effective antioxidants against oxidative stress damage is essential [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Potential of Tamarind Shell Extract against Oxidative Stress In Vivo and In Vitro

Huang

Han

et al. 2023

Molecules

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Tamarind shell is rich in flavonoids and exhibits good biological activities. In this study, we aimed to analyze the chemical composition of tamarind shell extract (TSE), and to investigate antioxidant capacity of TSE in vitro and in vivo. The tamarind shells were extracted with 95% ethanol refluxing extraction, and chemical constituents were determined by ultra-performance chromatography–electrospray tandem mass spectrometry (UPLC-MS/MS). The free radical scavenging activity of TSE in vitro was evaluated using the oxygen radical absorbance capacity (ORAC) method. The antioxidative effects of TSE were further assessed in 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH)-stimulated ADTC5 cells and tert-butyl hydroperoxide (t-BHP)-exposed zebrafish. A total of eight flavonoids were detected in TSE, including (+)-catechin, taxifolin, myricetin, eriodictyol, luteolin, morin, apigenin, and naringenin, with the contents of 5.287, 8.419, 4.042, 6.583, 3.421, 4.651, 0.2027, and 0.6234 mg/g, respectively. The ORAC assay revealed TSE and these flavonoids had strong free radical scavenging activity in vitro. In addition, TSE significantly decreased the ROS and MDA levels but restored the SOD activity in AAPH-treated ATDC5 cells and t-BHP-exposed zebrafish. The flavonoids also showed excellent antioxidative activities against oxidative damage in ATDC5 cells and zebrafish. Overall, the study suggests the free radical scavenging capacity and antioxidant potential of TSE and its primary flavonoids in vitro and in vivo and will provide a theoretical basis for the development and utilization of tamarind shell.

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“…Intraoperative application of mitomycin C to sclera bed is another strategy which has gained increasing acceptance but entail several complications. [19][20] The recurrence rate after amniotic membrane transplantation was initially reported to be 10.9% for primary and 37.5% for secondary pterygium, being much higher than recurrent rates of conjunctival auto grafts, 23 reducing to 3% and 9.5% respectively, after modifying the surgical technique, 24 which compared favorably with conjunctival auto grafts 14 being superior to that of bare sclera technique 25 that we have followed in our study as Fallah et al 26 performed for treatment of recurrent pterygia. Matin et al showed that amniotic membrane graft alone is effective adjunctive treatment for recurrence pterygia and the addition of intra operative mitomycin c did not further reduce recurrence rates.…”

Section: Occupationmentioning

confidence: 99%

Primary Pterygium Excision with Amniotic Membrane Grafting among Rural Eye Patients in Bangladesh

Matin,

Shahin,

Nawreen

et al. 2023

J. of Ad-din Women's Med. Coll.

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Objective: Since treatment of pterygium by topical and systemic medications is not effective, surgical treatment remains the only way to resolve the problem. This study was therefore aimed to evaluate the outcome of primary pterygium excision with amniotic membrane graft among patient with eye diseases in rural Bangladesh. Methodology: This study was conducted at the Pangsha Eye Hospital of District Rajbari among a total 280 pre-selected eye patients having primary pterygium over the period of 7 years (January 2012-June 2019). Surgical excision was performed with transplantation of preserved amniotic membrane on to the bare sclera. Every patient was followed up for at least next 6 months. Results: The results were evaluated in terms of recurrent pterygium growth and related complications. Of total 280 patients, pterygium was excision both of 138 (49.29%) being male and 142(50.71%) being female with mean ages of 43.36±10.88. The pterygium extended on to the corneas for 4.76±1.4 mm (range 3 to 8) mm. Only 11(4%) eyes demonstrated recurrent pterygium. Seven of them were male and 4 were female which was managed by second grafting leading to complete resolution. Of various complications, mild hematoma was observed in 3 cases, and, in 2 cases were had mild sclera dryness in bare scleral area after pterygium excision which were managed by topical steroid and artificial tear. Conclusion: Findings of this study yielded that primary pterygium excision with amniotic membrane transplantation is remains a safe and effective surgical technique with minimum recurrence rate. The Journal of Ad-din Women's Medical College; Vol. 11 (1), Jan 2023; p 4-13

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Oxidative stress and diabetic retinopathy

Cited by 4 publications

References 75 publications

Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes

Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes

Potential of Tamarind Shell Extract against Oxidative Stress In Vivo and In Vitro

Primary Pterygium Excision with Amniotic Membrane Grafting among Rural Eye Patients in Bangladesh

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