Potential of Tamarind Shell Extract against Oxidative Stress In Vivo and In Vitro

Li, Weixi; Huang, Rong-Ping; Han, Shao-Cong; Li, Xiyou; Gong, Haibiao; Zhang, Qiongyi; Yan, Chang-Yu; Li, Yi-Fang; He, Rong‐Rong

doi:10.3390/molecules28041885

Cited by 3 publications

(1 citation statement)

References 44 publications

(43 reference statements)

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“…The pH value of TSP was ca. 4.5, indicating that TSP was a weak acid due to the abundance of polyphenols [ 2 , 9 , 10 , 11 , 25 ]. The elemental analysis revealed that TSP consisted of approximately 48.0%, 45.6%, 5.7%, and 0.7% of carbon (C), oxygen (O), hydrogen (H), and nitrogen (N), respectively.…”

Section: Resultsmentioning

confidence: 99%

Application of Tamarind Shell as a Green Additive in Natural Rubber

Intiya,

Hatthapanit,

Thaptong

et al. 2024

Polymers

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The feasibility of using tamarind shell as an eco-friendly additive in natural rubber (NR) was studied. Tamarind shell powder (TSP) was prepared with different particle size ranges before being characterized by various techniques such as Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), elemental analysis, etc. The results of the FTIR and elemental analysis confirmed that TSP was mainly composed of amino acids (proteins), celluloses, and tannins. The thermal analysis revealed that TSP contained approximately 9% moisture, and its main constituents were stable up to 200 °C, which is higher than the normal processing temperature of rubber products. The addition of TSP to NR led to reductions in scorch time and cure time due to the presence of moisture and proteins. This phenomenon was more obvious with the decrease in TSP’s particle size. Even though the small addition of TSP (≤10 phr) did not cause any change in hardness, it significantly impaired the mechanical properties of the rubber vulcanizates, particularly tensile strength, elongation at break, and abrasion resistance. Such deterioration depended greatly on the TSP particle size, i.e., the finest particles (S-TSP) showed the least deterioration of mechanical properties. In summary, TSP can be considered a low-cost, eco-friendly bio-additive for rubbers. Nevertheless, it must be used with great care to avoid undesirable impacts on mechanical properties.

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Section: Resultsmentioning

confidence: 99%

Application of Tamarind Shell as a Green Additive in Natural Rubber

Intiya,

Hatthapanit,

Thaptong

et al. 2024

Polymers

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Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on Ethanol-Induced Damage to HepG2 Cells and Animal Models

Han

Huang

Zhang

et al. 2023

Foods

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Alcohol liver disease (ALD) is one of the leading outcomes of acute and chronic liver injury. Accumulative evidence has confirmed that oxidative stress is involved in the development of ALD. In this study, we used chick embryos to establish ALD model to study the hepatoprotective effects of tamarind shell exttract (TSE). Chick embryos received 25% ethanol (75 μL) and TSE (250, 500, 750 μg/egg/75 μL) from embryonic development day (EDD) 5.5. Both ethanol and TSE were administrated every two days until EDD15. Ethanol-exposed zebrafish and HepG2 cell model were also employed. The results suggested that TSE effectively reversed the pathological changes, liver dysfunction and ethanol-metabolic enzyme disorder in ethanol-treated chick embryo liver, zebrafish and HepG2 cells. TSE suppressed the excessive reactive oxygen species (ROS) in zebrafish and HepG2 cells, as well as rebuilt the irrupted mitochondrial membrane potential. Meanwhile, the declined antioxidative activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD), together with the content of total glutathione (T-GSH) were recovered by TSE. Moreover, TSE upregulated nuclear factor erythroid 2—related factor 2 (NRF2) and heme oxyense-1 (HO-1) expression in protein and mRNA level. All the phenomena suggested that TSE attenuated ALD through activating NRF2 to repress the oxidative stress induced by ethanol.

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Deciphering High-Temperature-Induced Lignin Biosynthesis in Wheat through Comprehensive Transcriptome Analysis

Han,

Wang,

et al. 2024

Plants

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This study systematically investigated the physiological and molecular responses of the wheat mutant ‘XC-MU201’ under high-temperature stress through comprehensive transcriptome analysis and physiological measurements. RNA sequencing of 21 samples across seven different treatment groups revealed, through Weighted Gene Co-expression Network Analysis (WGCNA), 13 modules among 9071 genes closely related to high-temperature treatments. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed significant enrichment of lignin biosynthesis-related modules under high-temperature conditions, especially at the H-10DAT, H-20DAT, and H-30DAT time points. Experimental results demonstrated a significant increase in lignin content in high-temperature-treated samples, confirmed by tissue staining methods, indicating wheat’s adaptation to heat damage through lignin accumulation. The phenylalanine ammonia-lyase gene (TaPAL33) was significantly upregulated under high-temperature stress, peaking at H-30DAT, suggesting its critical role in cellular defense mechanisms. Overexpression of TaPAL33 in the wheat variety ‘Xinchun 11’ enhanced lignin synthesis but inhibited growth. Subcellular localization of GFP-labeled TaPAL33 in tobacco cells showed its distribution mainly in the cytoplasm and cell membrane. Transgenic wheat exhibited higher PAL enzyme activity, enhanced antioxidant defense, and reduced oxidative damage under high-temperature stress, outperforming wild-type wheat. These results highlight TaPAL33’s key role in improving wheat heat tolerance and provide a genetic foundation for future research and applications.

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Potential of Tamarind Shell Extract against Oxidative Stress In Vivo and In Vitro

Cited by 3 publications

References 44 publications

Application of Tamarind Shell as a Green Additive in Natural Rubber

Application of Tamarind Shell as a Green Additive in Natural Rubber

Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on Ethanol-Induced Damage to HepG2 Cells and Animal Models

Deciphering High-Temperature-Induced Lignin Biosynthesis in Wheat through Comprehensive Transcriptome Analysis

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