Oxidative Stress and Cancer

Dasgupta, Amitava; Klein, Kimberly

doi:10.1016/b978-0-12-405872-9.00008-2

Cited by 5 publications

(6 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cancer describes a group of diseases that involve the growth of malignant tumors or abnormal cells with the capacity to invade or spread to other parts of the body, and destroy body tissue [ 46 ]. Various types of cancer have been reported to be linked to oxidative stress, including liver cancer, colon cancer, pancreatic cancer, skin cancer, breast cancer, bladder cancer and prostate cancer [ 47 ]. In addition to cancer, several neurodegenerative diseases, such as the commonly known Parkinson’s disease and Alzheimer’s disease, have also been linked to oxidative stress [ 48 , 49 ].…”

Section: Oxidative Stressmentioning

confidence: 99%

The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract

Kong

Olejar

et al. 2020

Antioxidants

View full text Add to dashboard Cite

The gastrointestinal (GI) tract is crucial for food digestion and nutrient absorption in humans. However, the GI tract is usually challenged with oxidative stress that can be induced by various factors, such as exogenous pathogenic microorganisms and dietary alterations. As a part of gut microbiota, Lactobacillus spp. play an important role in modulating oxidative stress in cells and tissues, especially in the GI tract. Oxidative stress is linked with excessive reactive oxygen species (ROS) that can be formed by a few enzymes, such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs). The redox mechanisms of Lactobacillus spp. may contribute to the downregulation of these ROS-forming enzymes. In addition, nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf-2) and nuclear factor kappa B (NF-κB) are two common transcription factors, through which Lactobacillus spp. modulate oxidative stress as well. As oxidative stress is closely associated with inflammation and certain diseases, Lactobacillus spp. could potentially be applied for early treatment and amelioration of these diseases, either individually or together with prebiotics. However, further research is required for revealing their mechanisms of action as well as their extensive application in the future.

show abstract

Section: Oxidative Stressmentioning

confidence: 99%

The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract

Kong

Olejar

et al. 2020

Antioxidants

View full text Add to dashboard Cite

show abstract

“…These are genetic predisposition, aging, menopause, and the level of estrogens, which lead to DNA damage and chromosomal aberrations. All these are responsible for the development and progression of breast cancer (Klingelhoeffer et al 2012 ; Dasgupta and Klein 2014 ). The human cancer cell lines that we have tested demonstrated considerable differences in their resistance to resistin-provoked oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

“…Its production is directly connected to insulin resistance and diabetes (WHO 2023). Our previous research (Avtanski et al 2019 ) and other studies (Dalamaga 2014 ; Dasgupta and Klein 2014 ; Wang et al 2018 ) have demonstrated that resistin induces EMT, thereby promoting breast cancer metastasis and progression.…”

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

The effect of resistin on the redox state of breast cancer cells

Pavlova,

Stojchevski,

Avtanski

2024

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Purpose Resistin is an inflammatory cytokine secreted mostly by adipocytes and immune cells that plays a role in the development of insulin resistance, diabetes, and cancer. We hypothesized that resistin’s inflammatory activity influences the free radical and oxidative stress pathways. Methods We used human breast carcinogenic (MCF-7 and MDA-MB-231) and non-carcinogenic (MCF-10A) cells in this investigation and correlated the absorbed resistin concentration with the change in oxidative stress (TBARS, carbonated proteins) and antioxidant activity (Antioxidant Capacity, SuperOxideDismutase, CATalase, Glutathione Peroxidase). Results Resistin was substantially more effective as a prooxidant at lower (12.5 ng/ml) concentrations, than at higher concentrations (25.0 ng/ml). Vitamin C did not appear to be an effective oxidative stress protector at antioxidant concentrations of 5.10–4 M. Leptin, at 100 ng/ml, did not result in conclusive oxidative stress or antioxidant defence stimulation, as expected. Conclusion Taken together, the findings support resistin’s role as a non-oxidative stress marker and a metabolic signaling molecule.

show abstract

“…During the progression of type 2 diabetes, pancreatic β-cell dysfunction is caused by increased ER stress, mitochondrial stress, and oxidative stress [138]. Moreover, ROS-induced DNA damage, in addition to the chemical modifications of macromolecules such as lipids and proteins, is considered to lead to the development of cancer, whereas many chemotherapy and radiation therapy treatments induce excessive oxidative stress to kill cancer cells [139,140]. Furthermore, genes in the KEAP1-NRF2 pathway are frequently mutated in certain cancers such as squamous cell carcinoma and lung adenocarcinoma showing the strong resistance to chemotherapy and radiation therapy [141,142].…”

Section: Cellular Stressesmentioning

confidence: 99%

Cellular Stress-Modulating Drugs Can Potentially Be Identified by in Silico Screening with Connectivity Map (CMap)

Gao

Kim

Lee

et al. 2019

IJMS

View full text Add to dashboard Cite

Accompanied by increased life span, aging-associated diseases, such as metabolic diseases and cancers, have become serious health threats. Recent studies have documented that aging-associated diseases are caused by prolonged cellular stresses such as endoplasmic reticulum (ER) stress, mitochondrial stress, and oxidative stress. Thus, ameliorating cellular stresses could be an effective approach to treat aging-associated diseases and, more importantly, to prevent such diseases from happening. However, cellular stresses and their molecular responses within the cell are typically mediated by a variety of factors encompassing different signaling pathways. Therefore, a target-based drug discovery method currently being used widely (reverse pharmacology) may not be adequate to uncover novel drugs targeting cellular stresses and related diseases. The connectivity map (CMap) is an online pharmacogenomic database cataloging gene expression data from cultured cells treated individually with various chemicals, including a variety of phytochemicals. Moreover, by querying through CMap, researchers may screen registered chemicals in silico and obtain the likelihood of drugs showing a similar gene expression profile with desired and chemopreventive conditions. Thus, CMap is an effective genome-based tool to discover novel chemopreventive drugs.

show abstract

Oxidative Stress and Cancer

Cited by 5 publications

References 86 publications

The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract

The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract

The effect of resistin on the redox state of breast cancer cells

Cellular Stress-Modulating Drugs Can Potentially Be Identified by in Silico Screening with Connectivity Map (CMap)

Contact Info

Product

Resources

About