Oxidative Stress and Bronchopulmonary Dysplasia: Evidences From Microbiomics, Metabolomics, and Proteomics

Capasso, Letizia; Vento, Giovanni; Loddo, Cristina; Tirone, Chiara; Iavarone, Federica; Raimondi, Francesco; Dani, Carlo; Fanos, Vassilios

doi:10.3389/fped.2019.00030

Cited by 33 publications

(23 citation statements)

References 87 publications

(83 reference statements)

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“…Overall, these findings suggest that quality improvement of perinatal and neonatal intensive care as evidenced by improved survival of peri-viable infants at 23-24 weeks' gestation could not only improve survival but also reduce morbidity rates of extremely preterm infants 7,28,30,31,33 . Given that oxygen toxicity increases the risk of death, BPD and ROP in the premature infants [3][4][5][6]29,34,35 , the controversial association of decreased ROP, BPD and survival observed in the lower oxygen saturation setting of 85-89%, and the increased ROP, BPD and survival observed in the higher oxygen saturation setting of 91-95% [12][13][14][15][16][17][18][19][20][21][22][23][24] is difficult to explain. For international comparison of neonatal research networks, the Japanese neonatal research network with the highest survival rate and proportion of infants at 24 weeks' gestation reported the highest BPD and ROP treatment rates, whereas the Swiss neonatal network with a low survival and proportion of infants at 24 weeks' gestation reported the lowest BPD and ROP treatment rates 2,25 .…”

Section: Discussionmentioning

confidence: 99%

Survival rate dependent variations in retinopathy of prematurity treatment rates in very low birth weight infants

Park

Hwang

Chang

et al. 2020

Sci Rep

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As increased oxidative stress causes increased mortality and morbidities like bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) in very low birth weight infants (VLBWIs), the conundrum of improved survival but increased ROP observed with the high oxygen saturation target range of 91–95% is difficult to explain. To determine the survival rate-dependent variation in ROP treatment rate, 6292 surviving eligible VLBWIs registered in the Korean Neonatal Network were arbitrarily grouped according to the survival rate of infants at 23–24 weeks’ gestation as group I (> 70%, n = 1626), group II (40–70%, n = 2984) and group III (< 40%, n = 1682). Despite significantly higher survival and lower BPD rates in group I than in groups II and III, the ROP treatment rate was higher in group I than in groups II and III. However, the adjusted odds ratios for ROP treatment were not significantly different between the study groups, and the ROP treatment rate in the infants at 23–24 weeks’ gestation was 21-fold higher than the infants at ≥ 27 weeks’ gestation. The controversial association between improved survival and reduced BPD reflecting quality improvement of neonatal intensive care but increased ROP treatment rate might be primarily attributed to the improved survival of the most immature infants.

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Section: Discussionmentioning

confidence: 99%

Survival rate dependent variations in retinopathy of prematurity treatment rates in very low birth weight infants

Park

Hwang

Chang

et al. 2020

Sci Rep

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“…The incidence of BPD in preterm infants with a gestational age of 30 weeks is 12%; the incidence with a gestational age of 25 to 26 weeks is 30-40% [8].In this study, the gestational age and birth weight of the BPD group were low, and multivariate analysis showed that birth gestational age < 30 weeks and birth weight < 1000 g were risk factors for BPD. This was consistent to the previous research results.…”

Section: Multivariate Logistic Regression Of Bpd Influencing Factorsmentioning

confidence: 49%

The Cytokines, Exhaled Nitric Oxide are Risk Factors in Preterm Infants for Bronchopulmonary Dysplasia

Zhang

Hou

et al. 2020

Preprint

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Background Bronchopulmonary dysplasia (BPD) remains the most frequently complication of extreme preterm infants. Multiple clinical factors and inflammatory markers have all been associated with BPD. Therefore, this study targeted to detect cytokines and fractional exhaled nitric oxide(FeNO) to evaluate their mechanism and possible predicted significance for BPD. Methods Preterm infants born at gestational age ≤ 32 weeks were recruited between January 2018 and October 2019. The clinical data of infant characteristics and maternal characteristics were collected. Our study detected a total of ten cytokines include IFN-γ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8 and TNF-α on day 1–3, day 7–14, and day 21–28 after birth via Meso Scale Discovery (MSD) technology. FeNO levels were measured when the infants met discharge criteria. Results A total of 46 preterm infants were enrolled in this study, including 14 infants in BPD group and 32 infants in control group. The gestational age 【(27.5 ± 1.3) vs. (29.9 ± 1.3) weeks】and birth weight【(1021 ± 261)g vs. (1489 ± 357)g】of BPD group were lower than those of control group. Multivariate logistic regression analysis showed that gestational age < 30 weeks, birth weight < 1000 g, PDA, longer mechanical ventilation and invasive ventilation duration were high risk factors for BPD. The cytokines of IL-6, IL-8 on day 7–14 and IL-4, IL-6, IL-8, TNF-α on day 21–28 were also the high risk factors for BPD. Other risk factors for BPD included elevated Eosnophils on day 21–28 and FeNO. Conclusion The preterm infants with PDA, prolonged mechanical ventilation tended to develop BPD. The FeNO, Eosnophils, cytokines such as IL-4, IL-6, IL-8, TNF-α were high risk factors for BPD. Our study speculate that NO was related to BPD though Th2-cell-mediatedinflammatory responses such as IL-4. The cytokines may provide a certain predictive value for the occurrence of BPD.

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“…Among the most promising drugs, according to our study, are those for the prevention of neurological damage, such as melatonin, retinoid lactoferrin, and vitamin E ( Figure 2). The microbiome has an important role in oxidative stress; in fact, the use of lactobacilli might be protective against OS lesions in preterm infants [97]. The search for new biomarkers, the improvement of care within the NICU, and the use of new machines and increasingly precise techniques for the study of oxidative stress products and related pathologies are guiding us towards increasingly targeted interventions (preventive, diagnostic, and therapeutic).…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects

et al. 2020

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Preterm birth (PTB), defined as parturition prior to 37 weeks of gestation, is the leading cause of morbidity and mortality in the neonatal population. The incidence and severity of complications of prematurity increase with decreasing gestational age and birthweight. The aim of this review study is to select the most current evidence on the role of oxidative stress in the onset of preterm complication prevention strategies and treatment options with pre-clinical and clinical trials. We also provide a literature review of primary and secondary studies on the role of oxidative stress in preterm infants and its eventual treatment in prematurity diseases. We conducted a systematic literature search of the Medline (Pubmed), Scholar, and ClinicalTrials.gov databases, retroactively, over a 7-year period. From an initial 777 articles identified, 25 articles were identified that met the inclusion and exclusion criteria. Of these, there were 11 literature reviews: one prospective cohort study, one experimental study, three case-control studies, three pre-clinical trials, and six clinical trials. Several biomarkers were identified as particularly promising, such as the products of the peroxidation of polyunsaturated fatty acids, those of the oxidation of phenylalanine, and the hydroxyl radicals that can attack the DNA chain. Among the most promising drugs, there are those for the prevention of neurological damage, such as melatonin, retinoid lactoferrin, and vitamin E. The microbiome also has an important role in oxidative stress. In conclusion, the most recent studies show that a strong relationship between oxidative stress and prematurity exists and that, unfortunately, there is still little therapeutic evidence reported in the literature.

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Oxidative Stress and Bronchopulmonary Dysplasia: Evidences From Microbiomics, Metabolomics, and Proteomics

Cited by 33 publications

References 87 publications

Survival rate dependent variations in retinopathy of prematurity treatment rates in very low birth weight infants

Survival rate dependent variations in retinopathy of prematurity treatment rates in very low birth weight infants

The Cytokines, Exhaled Nitric Oxide are Risk Factors in Preterm Infants for Bronchopulmonary Dysplasia

Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects

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