Oxidative stress and anxiety-like symptoms related to withdrawal of passive cigarette smoke in mice: Beneficial effects of pecan nut shells extract, a by-product of the nut industry

Reckziegel, Patrícia; Boufleur, Nardeli; Barcelos, Raquel Cristine Silva; Benvegnú, Dalila Moter; Pase, Camila Simonetti; Müller, Liz Girardi; Teixeira, Angélica M.; Zanella, Renato; Prado, Ana Cristina Pinheiro do; Fett, Roseane; Block, Jane Mara; Bürger, Marilise Escobar

doi:10.1016/j.ecoenv.2011.04.022

Cited by 37 publications

(26 citation statements)

References 89 publications

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“…During this procedure, the extract was protected from light [11]. The criteria for the selection of the dose of pecan shells AE were based on previous studies conducted in our laboratory, and the initial range of dose was based on previous studies [11,12].…”

Section: Plant Materials and Preparation Of Ae Of C Illinoensis Shellsmentioning

confidence: 99%

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Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Trevisan

Rossato

Hoffmeister

et al. 2014

Journal of Basic and Clinical Physiology and Pharmacology

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Background: Interest in pecan (Carya illinoensis) nut shells, a by-product of the nut industry, has increased due to its anti-inflammatory and antioxidant activities. The goal of this study was to evaluate the antinociceptive and antiedematogenic activity and the mechanisms of the pecan shell aqueous extract (AE). Methods: First, we performed fingerprinting of C. illinoensis AE. The antinociceptive and antiedematogenic effects of AE intragastric (i.g.) administration in mice (male Swiss mice 20-30 g) were evaluated using the acetic acid test or after subcutaneous (s.c.) paw injection of diverse transient receptor potential ankyrin 1 (TRPA1) agonists, including hydrogen peroxide (H2O2), allyl isothiocyanate, or cinnamaldehyde. We also observed AE antinociceptive and antiedematogenic effects after carrageenan s.c. paw injection and measured H2O2 production. Moreover, we observed the development of adverse effects after AE i.g. treatment. Results: The high-performance liquid chromatography fingerprinting of AE showed the presence of rutin. AE or rutin i.g. treatment produced antinociception in the acetic acid test and reduced the nociception and edema mediated by H2O2 s.c. hind paw injection or nociception induced by other TRPA1 agonists. Moreover, AE or rutin reduced the hyperalgesia, edema, and H2O2 production induced by carrageenan s.c. paw injection. No motor, gastric, or toxicological alterations were observed after AE administration. Conclusions: Collectively, the present results show that AE and its constituent rutin produced antinociceptive and antiedematogenic action in models of acute and persistent inflammatory nociception and it seems to be related to the inhibition of TRPA1 receptor activation.

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Section: Plant Materials and Preparation Of Ae Of C Illinoensis Shellsmentioning

confidence: 99%

“…Pecan shells have been pointed as a good source of antioxidant compounds [6,9]. In fact, the antioxidant activity of pecan shells was related with a wide range of pharmacological properties [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Trevisan

Rossato

Hoffmeister

et al. 2014

Journal of Basic and Clinical Physiology and Pharmacology

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“…Under conditions of ROS overproduction induced by the addition of melamine to the diet of female mice, Dai et al (2015) reported ovarian damage in the form of abnormal oocyte maturation. Reckziegel et al (2011) demonstrated that prolonged exposure to cigarette smoke in mice activates the release of free radicals, which cause an increase in lipid peroxidation in the brain and red blood cells and a decrease in plasma ascorbic acid level. In turn, Choi et al (1998) reported that one of the oxidative stress symptoms in hamsters is mitochondrial dysfunction, accompanied by a reduction in SOD and an increase in the concentration of glutathione peroxidase and glutathione reductase.…”

Section: Oxidative Stress In Laboratory Animalsmentioning

confidence: 99%

The application of mesenchymal progenitor stem cells for the reduction of oxidative stress in animals

Wojtas¹,

Zachwieja²,

Zwyrzykowska³

et al. 2017

Turk J Biol

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IntroductionEvery cell in both humans and livestock is involved in oxidation-reduction reactions. Their main products are oxygen free radicals, molecules having at least one unpaired electron in their structure (Betteridge, 2000;Czajka, 2006;Uttara et al., 2009). Under normal conditions, an organism seeking the balance equilibrium removes reactive compounds using protective substances and enzymes. Disturbances that occur in the accumulation of these are referred to as oxidative stress (Nisar et al., 2013;Konvičná et al., 2015).The organism is exposed to oxidative stress especially when subjected to intense physical and metabolic exertion. In the case of livestock, oxidative stress occurs as the result of continuous improvement and sharp selection in order to increase productivity (Jóźwik et al., 2012). According to Kimothi and Ghosh (2005), interracial mating is an alternative for alleviating the effects of oxidative stress, but research results of another author (Tanaka et al., 2008) did not confirm the above dependence.Metabolic disorders increase the incidence of oxidative stress. In dairy cows, the predisposing factor is dietary mistakes committed in the last few months of lactation and in the dry period (Blowey, 2005). In addition, fat increased mobilization from the subcutaneous tissue in the perinatal period leads to increased production of lipid peroxide and reactive oxygen species (Konvičná et al., 2015), which contributes to a reduction in the antioxidant capacity of an organism in early lactation (Turk et al., 2005). Similar results were observed in sheep and goats (El-Deeb, 2015).The oxidation-antioxidant imbalance may be an effect of 'stressor' activity. According to Dimitrios et al. (2003), their short-term impact in the form of psychological, physiological, or environmental stimuli activates an organism to induce neurohormonal regulatory mechanisms, which leads to homeostasis. In turn, animals that have been chronically exposed to stress are characterized by higher susceptibility to pathogens, which represents the effect of reducing the adjustment mechanisms (Kock et al., 1987;Ziegler, 1991).An innovative method of oxidative stress reducing in animals can be an application of stem cells, which are isolated from bone marrow, peripheral blood, and umbilical cord or adipose tissue. Mesenchymal stem cells (MSCs) have an ability of rapid multiplication, tissue repair, and regeneration. Moreover, MSCs can exhibit an immunosuppressive effect. According to Gala et al. (2010), an important feature of MSCs is their ability to synthesize and secrete cytokines. From the immunological point of view, cytokine proteins produced by leukocytes affect the Abstract: Oxidative stress is the primary cause of lowering of the body's immune status. It arises as a result of intense metabolic processes in humans and animals that involve a decrease in antioxidant enzymes activity at the expense of increased production of free radicals and reactive oxygen species (ROS). Consequently, this leads to oxidation of lipids, protein...

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“…Pecan nutshell is a phenolic rich agro-industrial byproduct, which polyphenolic profile includes high concentration of gallic acid, chlorogenic acid, p-hydroxybenzoic acid, epigallocatechin and epicatechin gallate (Prado et al, 2014). Due to the elevated concentration of polyphenols, the consumption of its infusion is associated with antioxidant activity, decreasing liver damage, reduction of total cholesterol and action as natural anxiolytic (Malik et al, 2009;Prado et al, 2014;Reckziegel et al, 2011, Müller et al, 2013. Additionally to the benefits to human health, Prado et al (2014) found that pecan nutshell infusion presents antibacterial activity against Gram-positive bacteria such as Listeria monocytogenes, Staphylococcus aureus, Bacillus cereus, Vibrio parahaemolyticus.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antimicrobial activity of pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell aqueous extract on minimally processed lettuce leaves

et al. 2016

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Pecan nutshell is a residue from food industry that has potential to be used as biopreservative in foods. The objective of this study was to evaluate the antimicrobial activity of pecan nutshell aqueous extract in vitro and its effectiveness to inhibit spoilage microorganisms on lettuce leaves. The results indicate that the aqueous extract presents inhibitory activity against important foodborne pathogenic bacteria such as Listeria monocytogenes, Salmonella Enteritidis, Staphylococcus aureus, Bacillus cereus, Aeromonas hydrophila and Pseudomonas aeruginosa. Antimicrobial activity was not observed against Corynebacterium fimi, Clostridium perfringens, Escherichia coli, and the phytopathogenic fungi tested. When applied onto lettuce leaves, pecan nutshell extract reduced the counts of mesophilic and psychrotrophic bacteria in 2 and 4 log CFU/g, respectively, during storage of leafy for 5 days at refrigeration temperature (5 °C). The extract was not effective to inhibit yeast on lettuce leaves. Thus, the aqueous extract of pecan shell showed great potential to be used as a natural preservative in foods, acting mainly in the inhibition of spoilage and pathogenic bacteria.

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Oxidative stress and anxiety-like symptoms related to withdrawal of passive cigarette smoke in mice: Beneficial effects of pecan nut shells extract, a by-product of the nut industry

Cited by 37 publications

References 89 publications

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

The application of mesenchymal progenitor stem cells for the reduction of oxidative stress in animals

Evaluation of the antimicrobial activity of pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell aqueous extract on minimally processed lettuce leaves

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