Oxidative Stress and Antioxidant Defense in Fish: The Implications of Probiotic, Prebiotic, and Synbiotics

Hoseinifar, Seyed Hossein; Yousefi, Samira; Doan, Hien Van; Ashouri, Ghasem; Gioacchini, Giorgia; Maradonna, Francesca; Carnevali, Oliana

doi:10.1080/23308249.2020.1795616

Cited by 226 publications

(80 citation statements)

References 129 publications

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“…In fish, the antioxidant defense system mainly includes enzymatic and non-enzymatic systems ( 15 ). The enzymatic system is mainly composed of CAT, SOD and GPx, and the main representative of non-enzymatic systems is GSH ( 58 ).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, fish possess effective antioxidant systems that prevent oxidative damage ( 15 ), for example the antioxidant enzymes catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD), as well as the low-molecular-weight antioxidant glutathione (GSH) ( 16 ). The activities of the antioxidant enzymes mentioned above, similar to the expression of the corresponding antioxidant genes, can be regulated by nuclear factor erythroid 2-related factor 2 (Nrf2) ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

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Dietary Lysine Levels Improved Antioxidant Capacity and Immunity via the TOR and p38 MAPK Signaling Pathways in Grass Carp, Ctenopharyngodon idellus Fry

et al. 2021

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An 8-week rearing trial was designed to appraise the dietary lysine levels on intestinal antioxidant capacity and immunity of grass carp fry. Six practical diets were prepared with graded levels of lysine (1.44, 1.79, 1.97, 2.44, 2.56 and 2.87% dry matter), and these diets were fed to grass carp fry. The results showed that the activities of intestinal antioxidant factors including catalase and glutathione peroxidase were markedly improved by the 2.44% dietary lysine compared with the control diet (1.44% dietary lysine) (P < 0.05). In terms of antioxidants, compared with the control diet, the 2.44% diet markedly upregulated the mRNA expression levels of target of rapamycin, S6 kinase1 and nuclear factor erythroid 2-related factor 2 pathway-related antioxidant genes, containing catalase and glutathione peroxidase 1α (P < 0.05) and downregulated the mRNA levels of Kelch-like ECH-associated protein 1 (P > 0.05). The mRNA levels of 4E-binding protein 2 showed the opposite trend compared with those of target of rapamycin, and the minimum value was observed in the group of 1.97% dietary lysine (P < 0.05). In terms of immunity, compared with the 1.44% diet, the 2.44% diet markedly suppressed the intestinal p38 mitogen-activated protein kinase and interferon γ2 mRNA levels (P < 0.05). Moreover, nuclear factor-kappa B p65, tumor necrosis factor α, interleukin 6, interleukin 8, and interleukin 15 mRNA levels all exhibited the same trend as p38 mitogen-activated protein kinase and interferon γ2; however, the difference among all the lysine treatments groups was not significant (P > 0.05). The anti-inflammatory cytokines transforming growth factor β2 and interleukin 4/13B mRNA levels in the intestine were remarkably upregulated by high dietary lysine levels (2.56 and 2.87%) (P < 0.05), and when the dietary lysine level reached 2.44%, the interleukin 4/13A mRNA levels were strikingly increased (P < 0.05). Overall, the data suggested that 2.44% dietary lysine could strengthen the immune and antioxidant capacities of grass carp fry via activating the target of rapamycin (TOR) signaling pathway, and suppressing the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway, which then improve the survival rate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary Lysine Levels Improved Antioxidant Capacity and Immunity via the TOR and p38 MAPK Signaling Pathways in Grass Carp, Ctenopharyngodon idellus Fry

et al. 2021

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“…MDA levels are indicators of LPO, which occurs during the oxidative damage of host tissues due to the overproduction of reactive oxygen species [ 62 , 63 ]. A decrease in serum MDA levels in all AC groups suggests a decrease in LPO.…”

Section: Discussionmentioning

confidence: 99%

Effects of Activated Charcoal on Growth, Immunity, Oxidative Stress Markers, and Physiological Responses of Nile Tilapia Exposed to Sub-Lethal Imidacloprid Toxicity

El-hameed¹,

Negm²,

Ismael³

et al. 2021

Animals

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The existing study was designed to assess the influences of dietary activated charcoal (AC) on the growth performance, immune responses, antioxidative status, and its mitigating roles against the physiological responses of Nile tilapia exposed a sub-lethal dose of a neonicotinoid agriculture pesticide, namely, as imidacloprid (IMID). Nile tilapia juveniles were fed on diets supplemented with graded AC levels as 0 (control), 5, 10, 15, and 20 g/kg diet for eight weeks. Growth, hemato-biochemical indices, and antioxidant and immune responses of fish in all groups were evaluated at the end of the feeding experiment. Afterward, fish in all experimental groups were subjected to a sub-lethal dose of IMID (0.0109 μg/L) for two weeks. Then, fish mortalities, stress indicators, and IMID residual levels in liver and flesh were examined. Results of the feeding experiment showed that total feed intake, weight gain, final body weights, and feed efficiency ratio were significantly increased in all AC groups compared with the control group. The survival rate was 100% in all experimental groups. No statistical differences were observed in the hematological picture of all experimental groups except the lymphocyte count, which was significantly increased in all AC groups compared to the control group. Total protein, albumin, globulin, nitric oxide levels, lysozyme, and respiratory burst activities were significantly increased in all AC groups. Serum alanine transaminase, aspartate transaminase, alkaline phosphatase activities, and malondialdehyde (MDA) levels were significantly decreased in all AC groups compared with the AC0 group. After exposure to a sub-lethal dose of IMID, survival rates were significantly elevated, and IMID residual levels in liver and flesh were significantly decreased in all AC groups than in the control group. Moreover, second-order polynomial regression showed that dietary supplementation with 14.30 g AC/kg diet resulted in the lowest blood glucose and serum MDA levels. Conclusively, we suggest dietary supplementation with 14.30 g AC/kg diet to modulate physiological responses of Nile tilapia to sub-lethal IMID toxicity.

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“…To avoid the negative effects of naturally producing reactive oxygen species, fish like other aerobic animals developed multiple approaches to scavenge excess free radicals that initially begin with the activity of antioxidant enzymes like SOD, CAT, and GPX ( 50 ). Therefore, activities of these antioxidant enzymes could serve as a biomarker of the antioxidant defense status of the organism.…”

Section: Discussionmentioning

confidence: 99%

Folic Acid-Coated Nanochitosan Ameliorated the Growth Performance, Hematological Parameters, Antioxidant Status, and Immune Responses of Rainbow Trout (Oncorhynchus mykiss)

et al. 2021

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In recent years, chitosan has gained considerable attention due to its favorable properties such as excellent biocompatibility and biodegradability for which it can be used as a health supplement for delivering bioactive compounds in the food industry and nutrition. In the present study, the effect of nanochitosans coated with folic acid (FA) was considered on the growth performance, hematological parameters, antioxidant status, and serum immune responses of rainbow trout (Oncorhynchus mykiss) fingerlings. Graded levels of FA-coated nanochitosan (0, 0.1, 0.25, 0.5, and 1 mg kg−1 diet) were added to the basal diet, and each experimental diet was fed to three groups of fish with an approximate weight of 31 g for 8 weeks. The experimental study demonstrated that dietary FA-coated nanochitosan significantly (P < 0.05) improved the weight gain ration (WGR), specific growth rate (SGR), and feed conversion ratio (FCR) of fish at the end of the feeding trial. There were also linearly increasing trends in red blood cells (RBCs), white blood cells (WBCs), hemoglobin (Hb), and hematocrit (Hct) of fish fed with increasing dietary chitosan/FA levels, whereas no significant difference was recorded in differential leukocyte count of fish among the treatments. In case of antioxidant responses, fish fed diet supplemented with 0.50 mg kg−1 FA-coated nanochitosan had the highest CAT and SOD activities, while the maximum activity of GPX was found in fish fed diet supplemented with 1.00 mg kg−1 FA-coated nanochitosan. Malondialdehyde activity also reached the lowest value in fish fed with 1.00 mg kg−1 FA-coated nanochitosan-supplemented diet (P < 0.05). Measured immune responses showed a linear augmentation in lysozyme activity (LA) with increasing dietary FA-coated nanochitosan, while linearly and quadratically increasing trends were recorded in immunoglobulin M (IgM) content as well as complement component C3 and C4 activities by increasing the supplementation of nanochitosan coated with FA (P < 0.05). Findings of the current study illustrated the positive effect of dietary FA-coated nanochitosan as a promising compound on improving the growth performance, feed utilization, antioxidant status, and immune responses of rainbow trout.

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Oxidative Stress and Antioxidant Defense in Fish: The Implications of Probiotic, Prebiotic, and Synbiotics

Cited by 226 publications

References 129 publications

Dietary Lysine Levels Improved Antioxidant Capacity and Immunity via the TOR and p38 MAPK Signaling Pathways in Grass Carp, Ctenopharyngodon idellus Fry

Dietary Lysine Levels Improved Antioxidant Capacity and Immunity via the TOR and p38 MAPK Signaling Pathways in Grass Carp, Ctenopharyngodon idellus Fry

Effects of Activated Charcoal on Growth, Immunity, Oxidative Stress Markers, and Physiological Responses of Nile Tilapia Exposed to Sub-Lethal Imidacloprid Toxicity

Folic Acid-Coated Nanochitosan Ameliorated the Growth Performance, Hematological Parameters, Antioxidant Status, and Immune Responses of Rainbow Trout (Oncorhynchus mykiss)

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