Oxidative stress: a possible mechanism for lead-induced apoptosis and nephrotoxicity

Jia, Qinghua; Ha, Xiaoqin; Yang, Zhihua; Lin, Hui; Yang, Xiaopeng

doi:10.3109/15376516.2012.718811

Cited by 42 publications

(29 citation statements)

References 40 publications

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“…Regarding the occupationally exposed populations, experimental studies have asserted that higher BLLs are associated with an increase in MDA or TBARS concentrations (Sandhir et al 1994 ;Kaczmarek-Wdowiak et al 2004 ;Jia et al 2012 ). All the studies that enrolled workers exposed to lead reported elevated levels of LPO products, except for 2 studies that did not identify a statistical signifi cance associated with higher BLLs (Table 4 ).…”

Section: Types and Utility Of Biomarkersmentioning

confidence: 89%

“…Lead-induced OS by ROS generation also represents a mechanism underlying lead neurotoxicity (Verstraeten et al 2008 ). Jia et al ( 2012 ) observed that lead promoted OS in the human mesangial cells, which can be an important mechanism underlying lead-induced nephrotoxicity. Moreover, lead has been proven to affect numerous systems throughout the body, including the hormonal, immune, and gastrointestinal systems, at different blood lead levels (BLLs) (EPA 2013 ).…”

Section: Introductionmentioning

confidence: 99%

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Lead Exposure and Oxidative Stress: A Systematic Review

Lopes

Peixe

Mesas³

et al. 2016

Reviews of Environmental Contamination and Toxicology

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Lead is an environmental toxicant that can induce oxidative stress (OS) via reactive oxygen species (ROS) generation, which has been reported as an important mechanism underlying lead toxicity (Gurer and Ercal 2000; Pande and Flora 2002; Kasperczyk et al. 2004a; Farmand et al. 2005; Verstraeten et al. 2008; Wang et al. 2009; Martinez-Haro et al. 2011). OS occurs when the generation of ROS exceeds the antioxidant system's ability to defend cells against oxidized molecules. ROS is a term generally used to refer to free radicals derived from O2 (e.g., superoxide anions [O2-] and hydroxyl radicals [OH-]) or to non-radical species (e.g. hydrogen peroxide [H2O2]) (Halliwell and Cross 1994).

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Section: Types and Utility Of Biomarkersmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Lead Exposure and Oxidative Stress: A Systematic Review

Lopes

Peixe

Mesas³

et al. 2016

Reviews of Environmental Contamination and Toxicology

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show abstract

“…12 The fluorescent imaging analysis using Hoechst and TOPRO-3 to assess nuclear morphology and cell membrane integrity revealed that despite the toxicity of lead, PZT nanoparticles showed no changes in either parameter suggesting that cell viability was maintained after exposure. 35 In the case of yeast cells, surface absorbed nanoparticles tend to damage the cell wall leading to the inhibition of cell proliferation and cell death and these responses are closely related with the nanoparticle size. 34 The mechanism of lead-based nanoparticles-induced cell death is traditionally apoptotic, via oxidative stress resulting in a decrease in mitochondrial activity inducing apoptosome formation.…”

Section: Bnt-bt and Pzt Nanoparticle Exposure Does Not Exert Cytotoximentioning

confidence: 99%

Bismuth-based nanoparticles as the environmentally friendly replacement for lead-based piezoelectrics

et al. 2015

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The use of nanotechnology in the piezoelectric industry conveys new concerns about the environmental toxicity related to lead based nanomaterials. Perovskite structured materials are extensively used as piezoelectrics, lead zirconate titanate (PZT) being the primary choice for sensors, actuators, etc., because of its powerful electromechanical conversion. However, during the life cycle of PZT piezoelectrics lead generally leaches into the environment over time, leading to human exposure and potential environmental hazard. Lead-free bismuth based-ferroelectric materials (BNT-BT) are promising substitutes due to their ability to provide all the piezoelectric attributes without leaching toxic material. Yet, little is known about the potential toxicity and interactions of these nanomaterials with biomolecules and their subsequent intracellular localization at the nanoscale. The aim of this study was to compare the biological impact and uptake of lead and bismuth-based piezoelectric nanoparticles in order to present a suitable substitute for the piezoelectric industry. Our results show that BNT-BT and PZT nanoparticles were internalized through the endolysosomal pathway following a first order kinetic, nanoparticles were localized in the lamellar bodies without inducing cell toxicity measured by mitochondrial activity and cell membrane integrity. Furthermore, BNT-BT nanoparticles were more stable as lead-based PZT released 20% more lead ions into cell culture media. Finally, we propose bismuth-based BNT-BT as a suitable candidate for commercial use as they avoid environmental leaching, imposing less risk during manufacturing and in occupational health, beside the high biocompatibility and similar physico-chemical properties.

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“…Some studies have confirmed the possible involvement of reactive oxygen species (ROS) in lead-induced toxicity. 3,[5][6][7] Any compound that induces oxidative stress does so by accelerating the generation of pro-oxidants and at the same time may also reduce cellular antioxidant defenses. Studies have reported that exposure to lead will lead to the disruption of the reducing status of a tissue and drive ROS formation, which will damage essential biomolecules such as proteins, lipids, and DNA.…”

Section: Introductionmentioning

confidence: 99%