Effects of isoquinoline alkaloid berberine on lipid peroxidation, antioxidant defense system, and liver damage induced by lead acetate in rats

Hasanein, Parisa; Ghafari-Vahed, Masumeh; Khodadadi, Iraj

doi:10.1080/13510002.2016.1140406

Cited by 61 publications

(37 citation statements)

References 37 publications

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“…Initial research revealed a significant role of SIRT1 signaling in mediating the antioxidant effect of BBR in diabetes (Pang et al, 2015) and in lipid metabolism (Hasanein et al, 2017). The lipid-lowering activity mediated by co-treatment with BBR and RSV was investigated in mice exposed to a high fat diet (Zhu et al, 2018).…”

Section: Berberinementioning

confidence: 99%

SIRT1 Activation by Natural Phytochemicals: An Overview

et al. 2020

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Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD + as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis. Deregulation of their expression and/or action may lead to tissue-specific degenerative events involved in the development of several human pathologies, including cancer, neurodegeneration, and cardiovascular disease. The most studied member of this class of enzymes is sirtuin 1 (SIRT1), whose expression is associated with increasing insulin sensitivity. SIRT1 has been implicated in both tumorigenic and anticancer processes, and is reported to regulate essential metabolic pathways, suggesting that its activation might be beneficial against disorders of the metabolism. Via regulation of p53 deacetylation and modulation of autophagy, SIRT1 is implicated in cellular response to caloric restriction and lifespan extension. In recent years, scientific interest focusing on the identification of SIRT1 modulators has led to the discovery of novel small molecules targeting SIRT1 activity. This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin. We will also discuss the potential therapeutic effects of these natural compounds in the prevention and treatment of human disorders, with particular emphasis on their metabolic impact.

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Section: Berberinementioning

confidence: 99%

SIRT1 Activation by Natural Phytochemicals: An Overview

et al. 2020

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“…They might reveal antioxidative and antiglycation properties, inhibit the activity of aldose reductase, and prevent apoptosis of the lens epithelial cells [ 49 ]. Berberine demonstrates all these aforementioned mechanisms, which have been demonstrated in numerous in vitro and in vivo studies on various cell lines, tissues, and organs [ 30 , 31 , 37 , 51 , 52 ], which suggests that berberine can be a promising compound protecting the lenses from opacity.…”

Section: Discussionmentioning

confidence: 93%

“…Berberine is a hydroxyl radical scavenger, and its main metabolite—berberrubine—reveals even greater antioxidative activity than berberine [ 28 ]. It has been reported that after treatment with berberine, the levels of the oxidative stress-related markers decreased while the levels of endogenous antioxidants increased in the tissues of laboratory animals [ 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Berberine on Glycation, Aldose Reductase Activity, and Oxidative Stress in the Lenses of Streptozotocin-Induced Diabetic Rats In Vivo—A Preliminary Study

Zych

Wojnar

Kielanowska

et al. 2020

IJMS

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Diabetes mellitus affects the eye lens, leading to cataract formation by glycation, osmotic stress, and oxidative stress. Berberine, an isoquinoline alkaloid, is a natural compound that has been reported to counteract all these pathological processes in various tissues and organs. The goal of this study was to evaluate whether berberine administered at a dose of 50 mg/kg by oral gavage for 28 days to rats with streptozotocin-induced diabetes reveals such effects on the biochemical parameters in the lenses. For this purpose, the following lenticular parameters were studied: concentrations of soluble protein, non-protein sulfhydryl groups (NPSH), advanced oxidation protein products (AOPP), advanced glycation end-products (AGEs), thiobarbituric acid reactive substances (TBARS), and activities of aldose reductase (AR), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Diabetes induced unfavorable changes in the majority of the examined parameters. The administration of berberine resulted in an increased soluble protein level, decreased activity of AR, and lowered AOPP and AGEs levels. The results suggest that berberine administered orally positively affects the lenses of diabetic rats, and should be further examined with regard to its anticataract potential.

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“…This might be due to the protective action of berberine on tissue damage. Evidence, In 2017 Hassanein K et al, reported that alkaloid berberine shows protective action on lipid peroxidation, antioxidant defense system by inhibiting liver damage due to its antioxidant defense mechanism 30 . In 2014 Mojarad TB et al, reported that the anticonvulsant and antioxidant effects of berberine in kainateinduced temporal lobe epilepsy in rats 31 .…”

Section: Fig 3: Effect Of Berberine On Serum Lipase Levels Of Dbtc Imentioning

confidence: 99%

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2020

IJPSR

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Effects of isoquinoline alkaloid berberine on lipid peroxidation, antioxidant defense system, and liver damage induced by lead acetate in rats

Abstract: Berberine exerted protective effects on lead-induced oxidative stress and hepatotoxicity in rats.

Cited by 61 publications

References 37 publications

SIRT1 Activation by Natural Phytochemicals: An Overview

SIRT1 Activation by Natural Phytochemicals: An Overview

Effect of Berberine on Glycation, Aldose Reductase Activity, and Oxidative Stress in the Lenses of Streptozotocin-Induced Diabetic Rats In Vivo—A Preliminary Study

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